Dr Weini Huang

Profile

Weini Huang currently works on modelling cancer evolution and species interactions in biological systems. Before being a lecturer in mathematical biology in 2018, she worked as a postdoctoral researcher in the Barts Cancer Institute, QMUL for modelling cancer spatial heterogeneity and the evolution of tumour resistance. She obtained her PhD in 2012 in Evolutionary Theory in the Max Planck Institute of Evolutionary Biology in north Germany.

Currently, Weini supervises 3 PhD students in the topics of evolutionary theory with application in species coevolution and cancer dynamics and 2 postdoctoral researchers. Weini is interested in understanding how diversity and population patterns are formed and maintained in nature/human cell populations through theoretical approaches as well as their connections with experimental/clinical observations. She collaborates with experimental evolution groups and cancer biologists/clinicians, such as the evolution of trade-offs in a bacteria-ciliate system and drug resistance in ovarian cancer, extrachromosal DNA, mtDNA dynamcis in healthy liver. 

Undergraduate Teaching

Differential Equations (2017-2018,2019-2020, 2020-2021)

Postgraduate Teaching

Complex Systems (2018-2019)

Research

Examples of research funding:

Publications

Google Scholar Profile 

1. Moeller et al. (2023, final version in print). Measures of genetic diversification in somatic tissues at bulk and single cell resolution. eLife. (joint corresponding author)
2. Li et al. (2023, in print) Mutation divergence over space in tumour expansion. Journal of the Royal Society Interface. (joint corresponding author)
3. A. Passman et al. (2023) Hepatocytes undergo punctuated expansion dynamics from a periportal stem cell niche in normal human liver. Journal of Hepatology. (joint corresponding author)
4. Haughey et al. (2023). First passage time analysis of spatial mutation patterns reveals sub-clonal evolutionary dynamics in colorectal cancer. PLoS Comput. Biol. (joint corresponding author)
5. J. Lange et al. (2022). The evolutionary dynamics of extrachromosomal DNA in human cancers. Nature Genetics, 54:1527-1533. (joint corresponding author)
6. Evans et al. (2022) Clonal transitions and phenotypic evolution in Barrett’s Esophagus. Gastroenterology, 162:1197-1209.
7. Lakatos et al. (2021) LiquidCNA: tracking subclonal evolution from longitudinal liquid biopsies using somatic copy number alterations. iScience, 24:102889.
8. Werner et al. (2020) Measuring single cell divisions in human cancers from multi-region sequencing data. Nat. Comm., 11, 1035.
9. Retel, Kowallik, Huang et al. (2019) The feedback between selection and demography shapes genomic diversity during coevolution. Science Advances 5 (10), eaax0530.
10. Chkhaidze et al. (2019) Spatially constrained tumour growth affects the patterns of clonal selection and neutral drift in cancer genomic data. Plos Computational Biology, 5(7):e1007243.
11. Park, Pichugin, Huang et al. (2019) Population size changes and extinction risk of populations driven by mutant interactors. Physical Review E 99 (2), 022305
12. Boddy, Huang, Aktipis. (2018) Life History Trade-Offs in Tumors. Current pathobiology reports 6 (4), 201-207. (Invited Review)
13. Baker A-M, Huang et al. (2017). Robust RNA-based in situ mutation detection delineates colorectal cancer subclonal evolution. Nat. Comm., 8 (1), 1998.
14. Huang et al. (2017) Dynamical trade-offs arise from antagonistic coevolution and decrease intraspecific diversity. Nat. Comm 8 (1), 2059. (corresponding author)
15. Amado, Fernández, Huang et al. (2016) Competing metabolic strategies in a multilevel selection model. Royal Society Open Science, 3:160544.
16. Huang et al. (2016). A resource-based game theoretical approach for the paradox of the plankton. PeerJ, 4:e2329. (joint corresponding author)
17. Huang, Hauert, Traulsen. (2015) Stochastic game dynamics under demographic fluctuations. Proceedings of the National Academy of Sciences, 112:9064-9069.
18. Amado, Huang et al. (2015). Learning process in public goods games. Physica A: Statistical Mechanics and its Applications, 430:21-31.
19. Huang, Werner, Traulsen. (2012) The impact of random frequency-dependent mutations on the average fitness. BMC Evolutionary Biology, 12:160.
20. Huang et al. (2012) Emergence of stable polymorphisms driven by evolutionary games between mutants. Nature Communications, 3:919.
21. Huang, Traulsen. (2010). Fixation probabilities of random mutants under frequency dependent selection. Journal of Theoretical Biology, 263(2):262∼ 268
22. Zhang, Liu, Huang et al (2008). Occurrence of Nematode parasites in raptors in Beijing, China. Journal of Raptor Research, 42(3):204∼209.

Preprints:

• Moeller et al. (2022). Accumulating waves of random mutations before fixation. BioRxiv. (senior author)
• Morison et al. (2023) Single-cell mutational burden distributions in birth-death processes. arXiv. (senior author)
• Hockings et al. (2023) Adaptive therapy achieves long-term control of chemotherapy resistance in high grade ovarian cancer. BioRxiv (contributing author)
• Hung et al. (2023) Coordinated inheritance of extrachromosomal DNA species in human cancer cells. BioRxiv (contributing author)

Supervision

Current supervision:

Iftikhar Ahmed (2020.01- Modeling genetic diversity in hierarchical structured human tissues)

Iftikhar is from Pakistan and holds an MPhil degree in Mathematics from Abdul Wali Khan University, Mardan, Pakistan. His area of research was Fluid Dynamics and worked on a thesis titled “Some Exact Solutions of the Boundary Layer Equation and Electro-magnetic Body Force”. Studying the infectious disease models has developed his interest in Mathematical Biology. Now he is working on the deterministic model and stochastic simulation of tumor accumulation in hierarchically organized tissue structures.

Elisa Scanu (2020.09 - Modeling ecDNA dynamcis in human cells)

Before joining Queen Mary University, Elisa studied in “La Sapienza” University of Rome, Italy, where she graduated (both BSc and MSc) in Applied Mathematics with the highest marks, and she spent a semester in Queen Mary University as an Erasmus+ student. She is also working in the Biology Department of “Tuscia” University of Viterbo, Italy, as a contract teacher for a 1st year module in Mathematics.

Elisa’s PhD project is to use stochastic models based on simple mechanistic assumptions to explain observed ecDNA patterns in human cells, including healthy tissues and tumours. The project will be done in cooperation with Barts Cancer Institute at the School of Medicine and Dentistry in Queen Mary University of London.

Christo Morison (2021.09 - Cancer dynamics and mutation burden distribution)

Funded by EU ITN programme, Christo works on modeling the mutation accumulation in birth-death processes. He also work on coevolution of cancer and immune cells as well as the progenitor cell dynamics in prostate cancer.

Alan Scaramangas (2022. 02 - Postdoctoral Researcher modeling ecDNA dynamics)

Poulami Ganguly (2022. 03 - Postdoctoral Researcher modeling ecDNA dynamics)

Past members:

Dr. Nathaniel Mon Pere (2020.12 - 2021. 05)

Nathaniel is a theoretical physicists worked in our group as a Postdoctoral researcher on the topic of somatic evolution and mutation burden dynamics. Now he is a postdoctoral researcher in Barts Cancer Institute, QMUL.

Dr. Magnus Haughey (2018.11 -2022.09) studied in physics and was a PhD student in our group modeling spatial dynamics in cancer evolution and is now a postdoctoral researcher in Barts Cancer Institute, QMUL.

Dr. Marius Moeller (2018.05 - 2022.12) studied applied mathematics and was a PhD student in our group working on the topic of random mutation accumulation in healthy tissue. He is currently a postdoctoral researcher in a bioinformatic group at the University of Lübeck.