Wolfson Institute of Preventive Medicine - Barts and The London

Professor Ranjit Manchanda

Ranjit

Professor of Gynaecological Oncology & Consultant Gynaecological Oncologist

Email: r.manchanda@qmul.ac.uk
Telephone: 020 7882 3510
Room Number: Room 131, Wolfson Institute

Profile

I joined Wolfson Institute of Preventive Medicine, QMUL, as a Professor of Gynaecological Oncology in Sep 2019. I earlier worked at Barts Cancer Institute, QMUL as a Clinical Senior Lecturer from June 2015. I have worked at Barts Health NHS Trust as a consultant Gynaecological Oncologist from June 2015. I previously worked as a Locum Consultant Gynaecological Oncologist at St Bartholomew’s Hospital (2014- 2015) & an Honorary Senior Lecturer at University College London, UK.

I completed a PhD in gynaecological oncology at UCL, along with a NIHR ACL Fellowship and subspecialty training in gynaecological oncology from UCLH and Bart's Hospital.

My Research interests are largely focused around Targeted Precision Prevention.

  • Population based germline testing for risk prediction, stratification, as well as targeted screening & cancer prevention.
  • Developing targeted Surgical Prevention strategies for ovarian and endometrial cancer.
  • Developing molecular/genetic testing strategies at cancer diagnosis for precision medicine and cancer prevention.
  • Management of familial gynaecological cancer
  • Screening for ovarian and endometrial cancer
  • Health Economic research issues for above
  • Gynaecological Oncology Training

I am Co-PI of the GCaPPS trial (population based BRCA testing RCT in the Jewish population); Chief Investigator (CI) on PROTECTOR (Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal) trial, the PROMISE Feasibility study (pilot population testing and personalised ovarian cancer risk prediction study in the general population), the SIGNPOST (SystematIc GeNetic testing for Personalised Ovarian cancer Therapy) study, RRESDO (study evaluating attitudes towards early salpingectomy); Co-Lead for UKCOGS (UK COVID and Gynaecological Cancer Study) and SURAKSHA- South Asian Breast Cancer Risk Prediction, Genetic testing & Health Management programme. I have worked on ovarian cancer screening trials (UKFOCSS, ALDO and UKCTOCS).

I lead the Bart's Hospital High-risk Precision Medicine and Cancer Prevention Clinical service and chair the London Cancer high-risk gynaecological cancer MDT. I am scientific advisor to BRCA Umbrella, GO Girls and chair the Independent Advisory Committee of the Mermaid Project (Demark).

I am co-Lead for the Cancer Prevention Theme at the Barts CRUK Cancer Centre. I am the Specialty Research Lead for Gynaecological Cancer, NIHR North Thames Clinical Research Network (CRN). I am a Co-PI of the Barts Gynae Cancer Tissue Bank. I am a member of the NCRI Ovarian Cancer Surgical Sub group and have a keen interest in ultra-radical debulking surgery for ovarian cancer. I lead the high-risk women’s Precision Prevention Clinic at Barts Health and chair the London Cancer High risk Gynaecological Cancer MDT. I am a member of number of advisory bodies and oversight committees.

I am the Integrated Academic Training Programme Director, London Specialty School of Obstetrics & Gynaecology, Health Education England; and Lead for the RCOG Advanced Professional Module (APM) in Clinical Research for North Central and North East London. I have served on a number of committees related to research and training and led a number of training initiatives in Gynaecological Oncology across Europe. I have served as President of the European Network of Young Gynaecological Oncologists (ENYGO) and member of the European Society of Gynaecological Oncology (ESGO) Council from 2011-2013.

Clinical Interests

Ovarian cancer radical debulking surgery, Sentinel node biopsy, Management of women at high risk of gynaecological cancer

Awards

Dec 2019              Shyam Agarwal Memorial Oration Award (Indian Cancer Genetics, Mumbai, India)

Mar 2019             NHS Innovation Accelerator (NIA) Fellowship Award

Mar 2019             Local Clinical Excellence Award (Barts Health)

Feb 2018              William Blair Bell Memorial Lecture Award, Royal College of Obstetricians & Gynaecologists (RCOG)

Jan 2011               Helen Harris Memorial Trust Travelling Fellowship Award

Feb 2010              NIHR Walport Academic Clinical Lecturer Award

2000-2001            Indian Council Medical Research Fellowship award

Team Members

Dr Li Sun (Senior Research Fellow)

Dr Faiza Gaba (Phd Student)

Dr Dhivya Chandrasekaran (MD Student, Clinical Fellow)

Dr Olivia Evans (Clinical Research Fellow)

Publications

Gaba F, Blyuss O, Liu X, Goyal S, Lahoti N, Chandrasekaran D, Kurzer M, Kalsi J, Sanderson S, Lanceley A, Ahmed M, Side L, Gentry-Maharaj A, Wallis Y, Wallace A, Waller J, Luccarini C, Yang X, Dennis J, Dunning A, Lee A, Antoniou AC, Legood R, Menon U, Jacobs I, Manchanda R. Population Study of Ovarian Cancer Risk Prediction for Targeted Screening and Prevention. Cancers 2020; 12(5), 1241. doi:10.3390/cancers12051241

Evans O, Manchanda R. Population-based Genetic Testing for Precision Prevention. Ca Prev Res 2020; DOI: 10.1158/1940-6207.CAPR-20-0002

Evans O, Gaba F, Manchanda R. Population-based Genetic Testing for Women's Cancer Prevention. Best Practice & Research Clinical Obstetrics & Gynaecology 2020; https://doi.org/10.1016/j.bpobgyn.2020.02.007

Manchanda R, Lieberman S, Gaba F, Lahad A, Levy-Lahad E. Population Screening for Inherited Predisposition to Breast and Ovarian Cancer. Annu Rev Genom Hum Genet. 2020; 21:13.1–13.40. https://doi.org/10.1146/annurev-genom-083118-015253

Gaba F, Manchanda R. Systematic Review of Acceptability, Cardiovascular, Neurological, Bone Health, and HRT Outcomes following Risk Reducing Surgery in BRCA carriers. Best Practice & Research Clinical Obstetrics & Gynaecology 2020; https://doi.org/10.1016/j.bpobgyn.2020.01.006

Manchanda R. Advances in Screening and Prevention of Women’s Cancers, Best Practice & Research Clinical Obstetrics & Gynaecology, 2020  https://doi.org/10.1016/j.bpobgyn.2020.03.008

Manchanda R, Buist D, Evans G. Unselected triple-gene BRCA1, BRCA2, PALB2 testing at breast cancer diagnosis. JAMA oncol 2020; doi:10.1001/jamaoncol.2020.0131

Sun L, Brentnall A, Patel S, Buist DSM, Bowles EJA, Evans DGR, Eccles D, Hopper J, Li S, Southey M, Duffy S, Cuzick J, dos-Santos-Silva I, Miners A, Sadique Z, Yang L, Legood R, Manchanda R. A cost-effectiveness analysis of multigene testing for all patients with breast cancer. JAMA Oncol 2019; doi:10.1001/jamaoncol.2019.3323

Gallagher A, Waller J, Manchanda R, Jacobs I, Sanderson S. Women’s intentions to engage in risk-reducing behaviours after receiving personal ovarian cancer risk information: an experimental survey study. PsyArXiv Pre Print 2019; https://doi.org/10.31234/osf.io/jqu87 

Manchanda R, Burnell M, Gaba F, Wardle J, Desai R, Gessler S, Side L, Sanderson S, Loggenberg K, Brady AF, Dorkins H, Wallis Y, Chapman C, Jacobs C, Legood R, Beller U, Tomlinson I, Menon U, and Jacobs I. Randomised trial of population based BRCA testing in Ashkenazi Jews: Long term outcomes. BJOG 2020; 127 (3): 364-375 https://doi.org/10.1111/1471-0528.15905 . PMID: 31507061

Wall J, Ryan N, Crosbie EJ, Arends MJ, Bosse T, Arif S, Asma F, Frayling I, Ganesan R, Hock YL, McMahon R, Manchanda R, McCluggage GW, Mukonoweshuro P, van Schalkwyk G, Smith JH, Tanchel B, Evans DG, Gilks BC, Singh N. Lynch Syndrome Screening in Gynaecological Cancers: Results of an International Survey with Recommendations for Uniform Reporting Terminology for Mismatch Repair Immunohistochemistry Results. Histopathology 2019 doi:10.1111/his.13925

Cohen PA, Powell A, Böhm S, Gilks BC, Stewart CJR, Meniawy TM, Bulsara M, Avril S, Brockbank EC, Bosse T, Focchi GRdA, Ganesan R, Glasspool RM, Howitt BE, Kim H; Lee JY, Le ND, Lockley M, Manchanda R, Mandalia T, McCluggage GW, McNeish I, Midha D, Srinivasan R, Tan YY, van der Griend, Yunokawa M, Zannoni GF, Singh N. Pathological chemotherapy response score is prognostic in tubo-ovarian high-grade serous carcinoma: a systematic review and meta-analysis of individual patient data. Gynecol Oncol 2019; 154(2):441-448. doi:10.1016/j.ygyno.2019.04.679

Manchanda R, Gaba F. A commentary on population genetic testing for primary prevention: changing landscape and the need to change paradigm. BJOG 2019; 126: 686–689. https://doi.org/10.1111/1471-0528.15657 PMID:30770625

Crosbie EJ, Ryan NAJ, Arends MA, Bosse T, Burn J, Cornes JM, Crawford R, Eccles D, Frayling IM, Ghaem-Maghami S, Hampel H, Kauff ND, Kitchener HC, Kitson SJ, Manchanda R, McMahon RFT, Monahan KJ, Menon U, Moller P, Moeslein G, Rosenthal A, Sasieni P, Seif MW, Singh N, Skarrott P, Snowsill TM, Steele R, Tischkowitz M, Manchester International Consensus Group, Evans DG. The Manchester International Consensus Group Recommendations for the Management of Gynecological Cancers in Lynch Syndrome. Genetics in Medicine 2019; https://doi.org/10.1038/s41436-019-0489-y 

Manchanda R, Burnell M, Gaba F, Sanderson S, Loggenberg K, Gessler S, Wardle J, Side L, Desai R, Brady AF, Dorkins H, Wallis Y, Chapman C, Jacobs C, Tomlinson I, Beller U, Menon U, and Jacobs I. Attitude towards and Factors affecting uptake of Population based BRCA testing in the Ashkenazi Jewish population: a cohort study. BJOG 2019; 126: 784–794. doi:10.1111/1471-0528.15654  PMID: 30767407

Gaba F, Piek J, Menon U, Manchanda R. Risk reducing early salpingectomy and delayed oophorectomy as a two staged alternative for primary prevention of ovarian cancer in increased risk women: a commentary. BJOG 2019; DOI: 10.1111/1471-0528.15651

Koutoukidis DA, Beeken RJ, Manchanda R, Burnell M, Ziauddeen N, Michalopoulou M, Knobf MT, Lanceley A. Diet, physical activity, and health-related outcomes of endometrial cancer survivors in a behavioural lifestyle programme: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomised controlled pilot trial. Int J Gynecol Cancer 2018; DOI: 10.1136/ijgc-2018-000039

Manchanda R, Gaba F. Population Based Testing for Primary Prevention: a Systematic Review. Cancers 2018, 10, 424; doi:10.3390/cancers10110424

Puntambekar S, Manchanda R. Surgical pelvic anatomy in gynecologic oncology. FIGO Cancer Report 2018. Int J Gynecol Obstet 2018; 143 (Suppl. 2): 86–92. DOI:10.1002/ijgo.12616

Vazquez MA, Marino IP, Blyuss O, Ryan A, Gentry-Maharaj A, Kalsi J, Manchanda R, Jacobs I, Menon U, Zaikin A. A Quantitative Performance Study of Two Automatic Methods for the Diagnosis of Ovarian Cancer. Biomedical Signal Processing and Control 2018; 46:86–93. https://doi.org/10.1016/j.bspc.2018.07.001

Blyuss O, Burnell M, Ryan A, Gentry-Maharaj A, Mariño IP, Kalsi J, Manchanda R, Timms JF, Parmar M, Skates SJ, Jacobs I, Zaikin A, Menon U. Comparison of longitudinal CA125 algorithms as a first line screen for ovarian cancer in the general population. Clin Cancer Res 2018; DOI:10.1158/1078-0432.CCR-18-0208

Chuang L, Bere J, Randall T, McCormack M, Schmeler K, Manchanda R, Rebbeck T, Jeng CJ, Pyle D, Quinn M, Trimble E, Naik R, Lai CH, Ochiai K, Denny L, Bhatla N. International Collaborations in Gynecologic Oncology Education and Research in Low- and Middle- Income Countries: Current Status, Barriers and Opportunities. Gynecologic Oncology Reports; 2018; 25: 65-69 https://doi.org/10.1016/j.gore.2018.05.005  

Yang X, Leslie G, Gentry-Maharaj A, Ryan A, Intermaggio M, Lee A, Kalsi JK, Tyrer J, Gaba F, Manchanda R, Pharoah PDP, Gayther SA, Ramus SJ, Jacobs I, Menon U, Antoniou AC. Evaluation of polygenic risk scores for ovarian cancer risk prediction in a prospective cohort study. J Med Genet; 2018 dx.doi.org/10.1136/jmedgenet-2018-105313

Manchanda R, Legood R. Population based germline testing for primary cancer prevention. Oncotarget, 2018; 9(69): 33062-33063. DOI:10.18632/oncotarget.25995

Chandrasekaran D, Manchanda R. Germline & somatic genetic testing in ovarian cancer patients. BJOG: Int J Obstet Gy, 2018 DOI:10.1111/1471-0528.15225

Manchanda R. Opportunistic salpingectomy for prevention of ovarian cancer. BJOG: Int J Obstet Gy, 2017; 124: 890. doi:10.1111/1471-0528.14655

Manchanda R, Blyuss O, Gaba F, Gordeev VS, Jacobs C, Burnell M, Gan M, Taylor R, Turnbull C, Legood R, Zaikin A, Antoniou AC, Menon U, Jacobs I. Current detection rates and time-to-detection of all identifiable BRCA carriers in the Greater London population. J Med Genet; 2018;   doi:10.1136/jmedgenet-2017-105195. PMID: 29622727

Manchanda R, Patel S, Gordeev V, Antoniou AC, Smith S, Lee A, Hopper JL, MacInnis RJ, Turnbull C, Ramus SJ, Gayther SA, Pharoah PDP, Menon U, Jacobs I, Legood R. Cost-effectiveness of population-based BRCA1, BRCA2, RAD51C, RAD51D, BRIP1, PALB2 mutation-testing in unselected general-population women. J Natl Cancer Inst 2018; 110(7): djx265. doi:10.1093/jnci/djx265   PMID:29361001

Patel S, Legood R, Evans DG, Turnbull C, Antoniou AC, Menon U, Jacobs I, Manchanda R. Cost effectiveness of population based BRCA1 founder mutation testing in Sephardi Jewish women. Am J Obstet Gynecol, 2018; DOI: 10.1016/j.ajog.2017.12.221

Manchanda R, Menon U. Setting the threshold for surgical prevention in women at increased risk of ovarian cancer. Int J Gynecol Cancer, 2018; 28(1): DOI: 10.1097/IGC.0000000000001147 PMID:29252925

Meisel SF, Freeman M, Waller J, Fraser L, Gessler S, Jacobs I, Kalsi J, Manchanda R, Rahman B, Side L, Wardle J, Lanceley A, Sanderson SC. Impact of a decision aid about stratified ovarian cancer risk-management on women's knowledge and intentions: a randomised online experimental survey study. BMC Public Health 2017; DOI 10.1186/s12889-017-4889-0

Manchanda R, Patel S, Antoniou AC, Levy-Lahad E, Turnbull C, Evans G, Hopper J, MacInnis RJ, Menon U, Jacobs I, Legood R. Cost-effectiveness of population based BRCA testing with varying Ashkenazi Jewish ancestry. Am J Obstet Gynecol, 2017; doi.org/10.1016/j.ajog.2017.06.038 PMID: 28690137

Koutoukidis DA, Beeken RJ, Manchanda R, Michalopoulou M, Burnell M, Knobf MT, Lanceley A. Recruitment, adherence, and retention of endometrial cancer survivors in a behavioural lifestyle programme: the Diet and Exercise in Uterine Cancer Survivors (DEUS) parallel randomised pilot trial. BMJ Open, 2017;7:e018015. doi:10.1136/bmjopen-2017-018015

Gan C, Chenoy, R, Chandrasekaran D, Brockbank E, Hollingworth A, Vimplis S, Lawrence AC, Jeyarajah A, Oram D, Deo N, Saravanamuthu J, Lam SS, Faruqi A, Singh N, Manchanda R. Persistence of fimbrial tissue on the ovarian surface following salpingectomy. Am J Obstet Gynecol, 2017; doi.org/10.1016/j.ajog.2017.06.004

Manchanda R, Legood R, Antoniou  AC, Pearce L, Menon U. Changing the Risk Threshold for Surgical Prevention of Ovarian Cancer. BJOG: Int J Obstet Gy, 2017; doi: 10.1111/1471-0528.14763  PMID:28548227

Bansal JK, Goldrick IG, Manchanda R, Olaitan A. Rapid access gynecological oncology clinic outcomes in North London, UK. Clinical Audit, 2017:9 19–23. http://dx.doi.org/10.2147/CA.S127369

Rosenthal AN, Fraser L, Philpott S, Manchanda R, Burnell M, Badman P, Hadwin R, Rizzuto I, Benjamin E, Singh N, Evans DRG, Eccles DM, Ryan A, Liston R, Dawnay A, Ford J, Gunu RG, Mackay J, Skates SJ, Menon U, and Jacobs IJ. Evidence of stage-shift in women diagnosed with ovarian cancer during Phase 2 of the UK Familial Ovarian Cancer Screening Study (UKFOCSS). J Clin Oncol, Mar 2017 DOI: 10.1200/JCO.2016.69.9330 PMID:28240969

Johnston C, Ng J, Manchanda R, Tsunoda AT, Chuang L. Variations in gynecologic oncology training in low (LIC) and middle income (MIC) countries (LMICs): common efforts and challenges. Gynaecol Oncol Rep, 2017; 20: 9–14. DOI: 10.1016/j.gore.2017.01.003

Gan C, Bossart M, Piek J, Halaska M, Haidopoulos D, Zapardiel I, Grabowski JP, Kesic V, Kimmig R, Cibula D, Lambaudie E Verheijen R, Manchanda R. Robotic and advanced laparoscopic surgical training in European gynaecological oncology trainees. Int J Gynaecol Cancer, 2017; 27(2): 375-381. DOI: 10.1097/IGC.0000000000000879

Gaba F, Manchanda R. Genetic Testing for Gynaecological Cancer. Obstetrics, Gynaecology and Reproductive Medicine, 2016 http://dx.doi.org/10.1016/j.ogrm.2016.11.001

Pennington M, Gentry-Maharaj A, Karpinskyj C, Miners A, Taylor J, Manchanda R, Iyer R, Griffin M, Ryan A, Jacobs IJ, Menon U, Legood R. Long-term secondary care costs of endometrial cancer: a prospective cohort study nested within the United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Plos One, 2016, DOI:10.1371/journal.pone.0165539 

Chuang LT, Randall TC, Denny L, Johnston CM, Schmeler KM, Covens AL, Cibula D, Bookman MA, Rawal S, DePetrillo D, Nam JH, Goodman A, Naik R, Manchanda R, Gaffney DK, Small W Jr, Creutzberg C, Rattray C, Kesic V, Paraja R, Eiken M, Belleson K, Coleman RL, Barakat RR, Trimble EL, Quinn M. Sister Society Meeting on Global Education Development and Collaboration: Meeting Report. Int J Gynecol Cancer. 2016 Jul;26(6):1186-8. doi:10.1097/IGC.0000000000000735.

Manchanda R, Legood R, Antoniou AC, Gordeev SV, Menon U. Specifying the risk threshold of premenopausal risk reducing salpingo-oophorectomy for ovarian cancer prevention: a cost-effectiveness analysis. J Med Genet 2016;53:591–599. doi:10.1136/jmedgenet-2016-103800. PMID:27354448

Manchanda R, Burnell M, Loggenberg K, Desai R, Wardle J, Sanderson S, Gessler S, Side L, Balogun N, Kumar A, Dorkins H, Wallis Y, Chapman C, Tomlinson I, Taylor R, Jacobs C, Legood R, Raikou M, McGuire A, Beller U, Menon U, and Jacobs I. Cluster randomised non-inferiority trial comparing DVD-based and traditional genetic counselling in systematic population testing for BRCA1/2 mutations. J Med Genet, 2016, 53(7):472-80. doi:10.1136/jmedgenet-2015-103740. PMID: 26993268

Burnell M, Iyer R, Gentry-Maharaj A, Nordin A, Liston R, Manchanda R, Das N, Gornall R, Beardmore-Gray A, Hillaby K, Leeson S, Linder A, Lopes A, Meechan D, Mould  T, Nevin J, Olaitan A, Rufford B, Shanbhag S, Thackeray A, Wood N, Reynolds K, Ryan A, Menon U. Benchmarking of surgical complications in gynaecological oncology: prospective multicentre study. BJOG, 2016; DOI: 10.1111/1471-0528.13994

Koutoukidis DA, Beeken RJ, Manchanda R, Burnell1 M, Knobf MT, Lanceley A. Diet and exercise in uterine cancer survivors (DEUS pilot) – piloting a healthy eating and physical activity program: study protocol for a randomized controlled trial. Trials, 2016: 17;130 DOI 10.1186/s13063-016-1260-1

Manchanda R, Menon U. Opportunistic Bilateral Salpingectomy (OBS) for prevention of ovarian cancer should be offered in the context of a clinical trial. BJOG, 2016

Manchanda R, Chandrasekaran D, Saridogan E, Burnell M, Crawford R, Brockbank E, Kalsi J, Jurkovic D, and Menon U. Should Opportunistic Bilateral Salpingectomy (OBS) for prevention of ovarian cancer be incorporated into routine care or offered in the context of a clinical trial? Int J Gynecol Cancer, 2016; 26(1): 31-32.

Manchanda R, Jacobs I. Genetic screening for gynaecological cancer: where are we heading? Future Oncol, Dec 2015 http://www.ncbi.nlm.nih.gov/pubmed/26638726

Manchanda R, Legood R, Pearce L, Menon U. Defining the risk threshold for risk reducing salpingo-oophorectomy for ovarian cancer prevention in low risk postmenopausal women. Gynecol Oncol, 2015, 139(3):487-94. http://dx.doi.org/10.1016/j.ygyno.2015.10.001 PMID:26436478

*Dilley J, *Manchanda R, Johnson M, Rosenthal AN, Gessler S, Menon U. Importance of serial CA125 measurements over an absolute cut-off value for detection of asymptomatic ovarian cancer in high-risk patients. Int J Gynecol Obstet, 2015 http://dx.doi.org/10.1016/j.ijgo.2015.09.013

Chandrasekharan D, Menon U, Evans G, Crawford R, Saridogan E, Jacobs C, Tischkowitz M, Brockbank E, Kalsi J, Jurkovic D, Manchanda R. Risk Reducing Salpingectomy and Delayed Oophorectomy in high risk women: views of cancer geneticists, genetic counsellors and gynaecological oncologists in the UK. Fam Cancer July 2015 DOI 10.1007/s10689-015-9823-y

Jervis S, Song H, Lee A, Dicks E, Harrington P, Baynes C, Manchanda R, Easton D, Jacobs I, Pharoah P, Antoniou A. A Risk Prediction Algorithm for Ovarian Cancer Incorporating BRCA1, BRCA2, Common Alleles and Other Familial Effects. J Med Genet 2015; 52(7):465-75. doi:10.1136/jmedgenet-2015-103077

Manchanda R, Legood R, Burnell M, McGuire A, Raikou M, Loggenberg K, Wardle J, Sanderson S, Gessler S, Side L, Balogun N, Desai R, Kumar A, Dorkins H, Wallis Y, Chapman C, Taylor R, Jacobs C, Tomlinson I, Beller U, Menon U, and Jacobs I. Cost effectiveness of population screening for BRCA mutations in Ashkenazi-Jewish women compared to family-history based testing. J Natl Cancer Inst 2015; 107(1):  doi:10.1093/jnci/dju380  PMID: 25435542 PMCID: PMC4301704

Manchanda R, Loggenberg K, Sanderson S, Burnell M, Wardle J, Gessler S, Side L, Balogun N, Desai R, Kumar A, Dorkins H, Wallis Y, Chapman C, R, Jacobs C, Tomlinson I, McGuire A, Beller U, Menon U, and Jacobs I. Population testing for cancer predisposing BRCA1/BRCA2 mutations in the Ashkenazi-Jewish community: a randomised controlled trial. J Natl Cancer Inst 2015; 107(1): doi:10.1093/jnci/dju379   PMID:25435541, PMCID:PMC4301703

Iyer R, Gentry-Maharaj A, Nordin A, Burnell M, Liston R, Manchanda R, Das N, Desai R, Gornall R, Beardmore-Gray A, Nevin J, Hillaby K, Leeson S, Linder A, Lopes A, Meechan D, Mould T, Varkey S, Olaitan A, Rufford B, Ryan A, Shanbhag S, Thackeray A, Wood N, Reynolds K, and Menon U. Predictors of complications in gynaecological oncological surgery. Br J Cancer 2014 doi: 10.1038/bjc.2014.630

Piek J, Bossart M, Boor K, Halaska M, Haidopoulos D, Zapardiel I, Grabowski J, Kesic V, Cibula D, Colombo N, Verheijen R, Manchanda R. The work place educational climate in gynecological oncology fellowships across Europe: the impact of accreditation. Int J Gynecol Cancer 2015; 25(1): 180-190. DOI: 10.1097/IGC.0000000000000323

Manchanda R, Hallaska MJ, Piek J et al. The need for more workshops in laparoscopic surgery and surgical anatomy for European gynaecological oncology trainees: a survey by ENYGO.  Int J Gynecol Cancer 2013; 23(6): 1126-31.

Kalsi J, Manchanda R, Menon U. Screening for gynaecological cancers. Expert Rev Obstet Gynecol. 2013; 8(2): 143–160

Manchanda R, Godfrey M, Wong-Taylor LA, Halaska MJ, Burnell M, Grabowski JP, Gultekin M, Haidopoulos D, Zapardiel I, Vranes B, Kesic V, Zola P, Colombo N, Verheijen R, Bossart M, Piek J. The need for accredited training in gynaecological oncology: a report from the European Network of Young Gynaecological Oncologists (ENYGO). Ann Oncol, 2013; 24(4), 944-52

Rosenthal AN, Fraser L, Manchanda R, Badman P, Philpott S, Mozersky J, Hadwin R,  Cafferty FH, Benjamin E, Singh N, Evans G, EcclesD, Skates SJ, MacKay J, Menon U, Jacobs IJ on behalf of the UK FOCSS collaborators. Results of Annual Screening in the UK Familial Ovarian Cancer Screening Study (UK FOCSS Phase 1) highlight need for strict adherence to screening schedule. J Clin Oncol 2013; 31(1):49-57. PMID:23213100

Brantnerova R, Manchanda R, Colombo N. The European Society of Gynaecological Oncology: Update on Objectives and Educational and Research Activities. Am Soc Clin Oncol Educ Book 2012; 32: 335-338

Manchanda R, Saridogan E, Abdelraheim A, Johnson M, Rosenthal AN, Benjamin E, Brunell C, Side L, Gessler S, Jacobs I, Menon U. Annual Outpatient Hysteroscopy and Endometrial Sampling (OHES) in HNPCC/ Lynch Syndrome (LS). Archives Gynecol Obstet, 2012; 286(6): 1555-62

Fourkala E, Gentry-Maharaj A, Burnell M, Ryan A, Manchanda R, Dawnay A, Jacobs I, Widschwendter M, Menon U. Histological confirmation of breast cancer registration and self-reporting in England and Wales: a cohort study within the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS). Br J Cancer. 2012; 106: 1910-6.

Manchanda R, Silvanto A, Abdelraheim A, Burnell M, Johnson M, Saridogan E, Rosenthal AN, Brunell C, Aslam N, Vashisht A, Pandis G, Jacobs I, Menon U, Benjamin E. Surgical diathermy induced tubal injury may affect detection of occult tubal lesions in high-risk women undergoing risk reducing salpingo-oophorectomy (RRSO). Int J Gynecol Cancer. 2012; 22: 881-8. doi:10.1097/IGC.0b013e31824b4093 PMID:22572844  

Manchanda R, Burnell M, Abdelraheim A, Johnson M, Sharma A, Rosenthal AN, Benjamin E, Brunell C, Saridogan E, Oram D, Side L, Gessler S, Jacobs I, Menon U. Factors influencing uptake and timing of risk reducing salpingo-oophorectomy (RRSO) in women at risk of familial ovarian cancer: a competing risk time to event analysis. BJOG 2012; 119: 527-36

Manchanda R, Drapkin R, Jacobs I, Menon U. The role of peritoneal cytology at risk-reducing salpingo-oophorectomy (RRSO) in women at increased risk of familial ovarian/tubal cancer. Gynecol Oncol 2012 Feb; 124(2):185-91.

Vaes E, Manchanda R, Autier P, Nir R, Nir D, Bleiberg H, Robert A and Menon U. Differential diagnosis of adnexal masses: A sequential use of the Risk of Malignancy Index and a novel computer aided diagnostic tool. Ultrasound Obstet Gynecol 2012; 39: 91–98.

Gultekin M, Dursun P, Vranes B, Laky R, Bossart M, Grabowski JP, Jurgen P, Grimm C, Dallaku K, Babloyan S, Moisei A, Van Gorp T, Cadron I, Markov P, Micevska A, Halaska M, Dahl Steffensen K, Gristsenko L, Nissi R, Lambaudie E, Tsitsishvili Z, Haidopoulos D, Dimitrios T, Peiretti M, Dunenova G, Macuks R, Hetland T, Michelsen TM, Martins F, Achimas-Cadariu P, Ulrikh E, Uharcek P, Malic S, Ognjenovic D, Zapardiel I, Johann S, Sukhin VS, Manchanda R. Gynaecologic Oncology Training Systems in Europe: A report from the European Network of Young Gynaecological Oncologists (ENYGO). Int J Gynecol Cancer 2011 Nov; 21(8):1500-6.

Manchanda R, Abdelraheim A, Johnson M, Rosenthal AN, Benjamin E, Brunell C, Brunell M, Side L, Gessler S, Saridogan E, Oram D, Jacobs I, Menon U. ‘Outcome of risk reducing salpingo-oophorectomy in BRCA carriers and women of unknown mutation status’ BJOG 2011; 118: 814-24

Vaes E, Manchanda R, Nir R, Nir D, Bleiberg H, Autier P, Menon U, Robert A. Mathematical models to discriminate between benign and malignant adnexal masses: potential diagnostic improvement using Ovarian HistoScanning. Int J Gynecol Cancer 2011; 21(1): 35-43.

Jacobs I, Gentry-Maharaj A, Burnell M, Manchanda R, Singh N, Sharma A, Ryan A, Seif M, Amso NN, Turner G, Brunell C, Fletcher G, Rangar R, Ford K, Godfrey K, Lopes A, Oram D, Herod J , Williamson K, Scott I, Jenkins H, Mould T, Woolas R, Murdoch J, Dobbs S, Leeson S, Cruickshank D, Skates S, Fallowfield L, Parmar M, Campbell S, Menon U. Sensitivity of transvaginal ultrasound screening for endometrial cancer in postmenopausal women: a case-control study within the UKCTOCS cohort. Lancet Oncol; 2011 12(1):38-48

Pichert G, Jacobs C, Jacobs I, Menon U, Manchanda R, Johnson M, Hamed H, Firth C, Evison M, Tutt A, de Silva L, Langman C, Izatt L. Novel one-stop multidisciplinary follow-up clinic significantly improves cancer risk management in BRCA1/2 carriers. Fam Cancer 2010 Sep;9(3):313-9

Manchanda R, Rosenthal A Burnell M, Fraser L, Mackay J, Skates S. Change in stage distribution observed with annual screening for ovarian cancer in BRCA carriers. J. Med. Genet. 2009; 46: 423-424

Manchanda R, Menon U, Beller U, Jacobs I. HNPCC or Lynch Syndrome: the Gynaecological perspective. Curr Opin Obstet Gynecol, 2009; 21(1): 31-38.

Manchanda R, Baldwin P, Crawford R, Vowler SL, Moseley R, Latimer J, Welton K, Shafi M. Effect of margin status on cervical intraepithelial neoplasia recurrence following LLETZ in women over 50 years. BJOG, 2008; 115: 1238-42

Manchanda R, Palep-Singh M, Prentice A. Can uterine artery embolisation affect endometrial perfusion and function. J Obstet Gynaecol, 2008; 28(2): 246-248

Manchanda R, Kriplani A. Giant malignant ovarian tumor: a case report. Int J Gynecol Cancer, 2005; 15(6):1135-1137.

Manchanda R, Sriemevan A. Anaphylactoid syndrome caused by amniotic fluid embolism following manual removal of placenta. J Obstet Gynaecol, 2005 Feb; 25(2):201-202.

Manchanda R, Refaie A. Acute pneumoperitoneum following coitus. CJEM, 2005; 7(1): 51-3.

Kriplani A, Agarwal N, Parul, Sharma MC, Manchanda R. Bilateral seminoma in a 45X/46XY mosaic with Turner’s phenotype. An unusual case of mixed gonadal dysgenesis. J Obstet & Gynae Res, 2003; 29(2): 63-66.

Kriplani A, Manchanda R, Nath J, Takkar D. “A randomized trial of danazol pretreatment prior to endometrial resection.” Eur J Obstet Gynecol Reprod Biol, 2002; 103(1): 68-71.

Kriplani A, Manchanda R, Agarwal N, Nayar B. “Laparosopic ovarian drilling in clomiphene citrate-resistant patients with polycystic ovary syndrome.” J Am Assoc Gynecol Laparosc, 2001; 8(4): 511-518.

Kriplani A, Manchanda R, Kumar D, Takkar D. “Depot Medroxy Progesterone Acetate: A poor preparatory agent for endometrial resection.” Gynecol Obstet Invest, 2001;52(3): 180-3

Kriplani A, Agarwal N, Roy KK, Manchanda R, Singh MK. “Laparoscopic management of Sertoli-Leydig cell tumours of ovary. A report of two cases.” J Reprod Med, 2001;46(5):493-6

Manchanda R, Kriplani A. “Alternatives to oestrogen replacement therapy for the treatment of menopausal symptoms.”  Indian J Clin Prac, 2000; 10(8): 69-76.

Buckshee K, Manchanda R, Dadhwal V. “Reproductive performance in patients with thyroid disorders.” J Obstet Gynaecol India, 1999; 49(1): 45-47.