Professor Ranjit Manchanda

Profile

I was appointed as Professor of Gynaecological Oncology at Wolfson Institute of Population Health, QMUL in Sep 2019. I worked at Barts Cancer Institute, QMUL as a Clinical Senior Lecturer from June 2015. I have worked as a consultant Gynaecological Oncologist at Barts Health NHS Trust from June 2015. From 2014- 2015 I worked as a Locum Consultant Gynaecological Oncologist at Barts Health and Honorary Senior Lecturer at University College London, UK. I completed a PhD in gynaecological oncology at UCL, followed by a NIHR ACL Fellowship and subspecialty training in gynaecological oncology from UCLH and Bart's Hospital.

Research:

My research is focused on Targeted Precision Prevention. This includes population-based genetic testing, mainstreaming genetic testing and precision medicine approaches for risk prediction, population stratification, targeted screening, cancer prevention (including surgical) and management of familial gynaecological cancer. I have a keen research interest in health economic issues related to these areas.

I am Chief Investigator (CI) on PROTECT (PROTECT: Population based Germline testing for Early detection and Cancer Prevention); PROTECTOR (Preventing Ovarian Cancer through early Excision of Tubes and late Ovarian Removal) trial; DETECT-2 (Direct to Patient testing at Cancer diagnosis for Precision Prevention) study; PROMISE Feasibility study (pilot general population testing and personalised ovarian cancer risk prediction study); SIGNPOST (SystematIc GeNetic testing for Personalised Ovarian cancer Therapy) study and RRESDO (study evaluating attitudes towards early salpingectomy) studies; Co-PI of GCaPPS trial (population based BRCA testing RCT in the Jewish population); Co-Lead for UKCOGS (UK COVID and Gynaecological Cancer Study); Co-lead for SURAKSHA- South Asian Breast Cancer Risk Prediction, Genetic testing & Health Management programme. I have worked on ovarian cancer screening trials (UKCTOCS, UKFOCSS and ALDO).

Research

Publications

Supervision

Xia Wei: Decision Analysis and Economic Modelling for Ovarian Cancer Prevention. Funding: Rosetrees Trust and China Medical Board

Samuel Oxley: Prevention of Endometrial Cancer. Funding: Rosetrees Trust

Jyotsna Pundir: Role of Myo-inositol in Poly Cystic Ovary Syndrome. Funding: Self funded

Dhivya Chandrasekaran: Implementation of unselected germline and somatic genetic testing in epithelial ovarian cancer delivered through a cancer-multidisciplinary pathway. Funding: Barts Charity

Faiza Gaba: Targeted Prevention of Ovarian Cancer. Funding: Rosetrees Trust and Barts Charity