DERI Seminar with Dr Yung-Yao Lin
When: Thursday, May 1, 2025, 11:00 AM - 12:00 PM
Where: Teams
Speaker: Dr Yung-Yao Lin, Sen Lecturer at the Centre for Genomics and Child Health
Title: Engineered human pluripotent stem cells for neuromuscular disease modelling and therapeutics development
Bio: Dr Yung-Yao Lin’s research is centred on stem cell bioengineering and regenerative medicine. He has made significant contribution towards elucidating mechanisms of neuromuscular disorders (PMIDs: 22522421, 23453667, 23768512, 27130732). By harnessing patient-derived pluripotent stem cells (PSCs), CRISPR-mediated genome editing and bioengineering technologies, his group has developed isogenic pairs of human PSC-based microphysiological models that can facilitate mechanistic understanding of neuromuscular diseases and tissue injury/regeneration, as well as therapeutics testing (PMIDs: 31566294, 34516770, 36418198, 36908638, 35083887). Recently, the Lin lab developed a clinically relevant hydrogel-based transplantation procedure that improves animal welfare (3Rs impact – Refinement) and achieves long-term engraftment (PMID: 40056909). Dr Lin has obtained substantial research funding from industry (Pfizer, AstraZeneca), patient charities and UKRI to further advance human-relevant microphysiological systems for predictive modelling of human diseases and injury, drug development and regenerative therapy.
Dr Yung-Yao Lin, is a Senior Lecturer at the Centre for Genomics and Child Health, Blizard Institute, FMD
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