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School of Biological and Chemical Sciences

Dr Guifen Chen


Lecturer in Neurobiology

Telephone: +44 (0)207 882 6669
Room Number: Room 3.12, Fogg Building


Guifen has recently started her own research group at the school of Biological and Chemical Sciences, QMUL, following her post-doctoral research at University College London (with Prof. John O’Keefe and then Prof Francesca Cacucci).

Guifen’s group studies the neuronal basis of spatial cognition and memory in mice, making use of the state-of-the-art virtual reality techniques and in vivo electrophysiological recording techniques.

ORCID iD: 0000-0002-5459-660X

Twitter: @GuifenChen

Undergraduate Teaching

Fundamentals of Neurobiology (SNU209)




Research Interests:

The ability to navigate is an essential skill required by both humans and animals. Animals can use sensory cues across modalities, such as visual, auditory, olfactory, integrated with self-motion cues, to find their way home from a food searching journey. Neural activity in the hippocampus and adjacent cortical areas, has been shown to correlate with the physical location of an organism. However, it is not clear how an internal unified representation of space, which supports navigation, is generated by integrating sensory inputs across modalities. 

 Virtual reality offers a powerful tool for investigating spatial cognition, allowing environmental manipulations that are impossible in the real world. Two-dimensional immersive virtual reality allows a close approximation of spatial representation in the real world. Hence, my laboratory is studying the across-modal navigation in virtual environments, combining virtual reality techniques with in vivo electrophysical recording and two-photon imaging.

Watch a mouse running in a virtual square environment 

Mouse wearing VR headset



  1. Chen G, Lu Y, King J, Cacucci F, Neil Burgess N. (2019) Differential influences of environment and self-motion on place and grid cell firing. Nature Communications. 10, 630.
  2. C. Whittington, T. H. Muller, S. Mark, G. Chen, C. Barry, N. Burgess, T. E. Behrens. (2019).The Tolman-Eichenbaum Machine: Unifying space and relational memory through generalisation in the hippocampal formation. Biorxiv, 770495.
  3. Chen G, Hayman R, Lu Y, King J, Keck T, Cacucci F, Burgess N (2018) 2-photon imaging of mouse hippocampus during virtual navigation of open arenas. SfN Abstr. 689.20/FFF11.
  4. Chen G * (2018) Identifying posture cells in the brain. Science. 362(6414):520-521. (*corresponding)
  5. Chen G, King JA, Lu Y, Cacucci F, Burgess N. (2018) Spatial cell firing during virtual navigation of open arenas by head-restrained mice. Elife. Jun 18;7.
  6. Li S, Xu J, Chen G, Lin L, Zhou D, Cai D. (2017) The characterization of hippocampal theta-driving neurons - a time-delayed mutual information approach. Scientific Reports. Jul 17;7(1):5637.
  7. Chen G *, Manson D, Cacucci F, Wills TJ. (2016) Absence of Visual Input Results in the Disruption of Grid Cell Firing in the Mouse. Current Biology. Sep 12;26(17):2335-42. (*co-corresponding)
  8. Zhang L, Ma X, Chen G, Barkai E, Lin L. (2016) Theta Rhythmic Clock-Like Activity of Single Units in the Mouse Hippocampus. J Neurosci. Apr 20;36(16):4415-20.
  9. Chen, G., King, J., Burgess, N., and O’Keefe, J. (2013) How vision and movement combine in the hippocampal place code. Proc Natl Acad Sci USA. 110 (1) 378-383.
  10. Zhang H, # Chen G, #  (# equal contribution), Kuang H, Tsien JZ. (2013) Mapping and deciphering neural codes of NMDA receptor-dependent fear memory engrams in the hippocampus. PLoS One. 8(11):e79454.
  11. Tsien JZ, Li M, Osan R, Chen G, Lin L, Wang PL, Frey S, Frey J, Zhu D, Liu T, Zhao F, Kuang H. (2013) On initial Brain Activity Mapping of episodic and semantic memory code in the hippocampus. Neurobiol Learn Mem. 105:200-10.
  12. Zhang L, Chen G, Niu R, Wei W, Ma X, Xu J, Wang J, Wang Z, Lin L. (2012) Hippocampal theta-driving cells revealed by Granger causality. Hippocampus, 22(8):1781-93.
  13. Oşan, R., # Chen, G.,# ( # equal contribution), Feng, R., and Tsien, J.Z. (2011) Differential Consolidation and pattern reverberations within episodic cell assemblies in the mouse hippocampus. PLoS One, 6(2):e 16507.
  14. Chen, G., Wang, L.P., and Tsien, J.Z. (2009) Neural population-level memory traces in the mouse hippocampus. PLoS One, 4(12):e 8256.
  15. Lin, L., Chen, G., Kuang, H., Wang, D., and Tsien, J.Z. (2007) Neural encoding of the concept of nest in the mouse brain. Proc Natl Acad Sci USA, 104: p. 6066-71.
  16. Lin, L., Chen, G., Xie, K., Zaia, K.A., Zhang, S., and Tsien, J.Z., (2006) Large-scale neural ensemble recording in the brains of freely behaving mice. J Neurosci Methods, 155: 28-38.
  17. Jiang, C., Chen, G., Zeng, X., Ouyang, K., and Hu, Y. (2003) Generation of a bioactive neuropeptide in a cell-free system. Analytical Biochemistry, 316: 34-40.
  18. Chen, G., Kuang, H., Cui, L., Zhang, L., and Lin, L., (2003) Complexity analysis on spike trains of the single auditory nerve. ACTA BIOPHYSICA SINICA, 19: 297-302.
  19. Chen, G., and Lin, L. (2003) Progress in the research of LTP in hippocampus. Chinese J. Nature, 25: p. 156-61.