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Pragmatic Clinical Trials Unit

Trials within Cohorts (TwiCs) May webinar series

This course is not currently available: further updates will be announced in due course.


The Trials within Cohorts (TwiCs) approach combines observational and experimental research methods (observational cohorts + randomised controlled trials) in order to create an efficient infrastructure for the implementation of multiple trials. The approach was first described in 2010 as the ‘cohort multiple’ RCT (cmRCT) design (Relton & Nicholl et al) and subsequently refined by Young-Afat et al, (2016).  CONSORT guidelines for reporting Trials Using Cohorts and Routinely Collected Data are currently in development (Kwakkenbos et al, 2018).

Webinar Series

The Pragmatic Clinical Trials Unit at QMUL presented a series of short webinars in May 2021:

Monday 17 May 2021
Introduction to Trials within Cohorts (TwiCs)
Dr Clare Relton
Hospital based Trials within Cohorts (TwiCs)
Professor Helena Verkooijen
Tuesday 25 May 2021
Analysis of Trials within Cohorts (TwiCs)
Dr Petter Viksveen


Thursday 27 May 2021
Ethics of Trials within Cohorts (TwiCs)
Dr Clare Relton

Who this course is for

Anyone involved in the design, conduct, analysis or reporting of pragmatic trials in the academic or NHS sector. The course will be of interest to all triallists, including principal investigators, trial managers, early career researchers and PhD students


The 2021 course comprised a short webinar series via Zoom. 


Further details

For further information and to register your interest in future courses please contact 

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