Molecular Genetics (BIO163)
Embryonic development is an intricate process governed by gene-regulatory interactions that occur with spatial and temporal precision. Given the complexity, it can seem surprising how reliable this process is even when gene function is lost. Our research uses zebrafish and functional genomics approaches to study the underpinnings of phenotypic robustness during embryonic development. Specifically, we are interested in understanding paralog interactions and gene expression plasticity.
We also use our large mutant collection to investigate a range of disease mechanisms in collaboration with other researchers. Some of our current projects are on modelling a digenic myopathy, identifying genes involved in addiction-related behaviours, and finding host factors of TB susceptibility.
For more information go to buschlab.org