Chiara Terzolo

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Examination of a Supplement to Manage Mood and Brain Activity in Women with Premenstrual Dysphoric Disorder

Premenstrual Dysphoric Disorder (PMDD), is a debilitating psychiatric disorder that affects 3-8% of women of reproductive age across the world. As a severe form of premenstrual syndrome (PMS) it is characterized by cognitive-affective and physical symptoms, especially severe depression and anxiety during the luteal phase. Current treatments are largely inadequate and/or have strong side effects.

Nutritional deficiencies contribute to depression and anxiety in the general population. About 40% of those on Western diets lack sufficient nutrients including Omega-3 polyunsaturated fatty acids (PUFAs), vitamin D and saffron, and low Omega-3 intake is linked with depression, anxiety and poor mental health. Supplementation of these nutrients has been shown to reduce depression and anxiety, especially in women.

The DITTO® supplement is a nutritional supplement that provides a standardised formulation containing ingredients, such as Omega 3, vitamin D and saffron. These ingredients were selected based on evidence from randomised controlled trials demonstrating efficacy in populations with PMS, PMDD or dysmenorrhea. However, the ability of this supplement to alleviate symptoms of PMDD has not yet been demonstrated.

This project will therefore determine the effects of this nutritional supplement to improve wellbeing in women with PMDD. We will examen its efficiency in reducing PMDD symptom severity, as well as anxiety and depression, and explore associated changes in brain activity measured with EEG.

Research