Publications
Publications from members of the Barts Centre for Squamous Cancer.
2025:
How do we avoid over-treating skin cancer in people with severe frailty and limited life expectancy? Powell JB, Dhesi JK, Harwood CA, McGrath EJ, Venables ZC, Chua SL, Keohane SG, Mallipeddi R, Marsden JR, Matin RN, Sharma A, Mohd Mustapa MF; British Association of Dermatologists’ Clinical Standards Unit and guideline development groups for managing people with cutaneous squamous cell carcinoma, basal cell carcinoma, squamous cell carcinoma in situ, Merkel cell carcinoma and actinic keratosis. Br J Dermatol. 2025 May 15:ljaf174. doi: 10.1093/bjd/ljaf174. Online ahead of print. PMID: 40373195
YAP1-NUTM1 fusions are infrequent in porocarcinomas arising in a cohort including immunocompromised patients. Eisner M, Winn R, Oliphant T, Xavier MJ, Husain A, Harwood CA, Rajan N. J Eur Acad Dermatol Venereol. 2025 Apr 2. doi: 10.1111/jdv.20681. Online ahead of print. PMID: 40172148
The landscape of long non-coding RNA during cSCC progression. Bone M, Schreyer D, Treanor-Taylor M, Proby CM, Harwood CA, Leigh IM, Bailey P, Inman GJ. Br J Dermatol. 2025 Mar 27:ljaf108. doi: 10.1093/bjd/ljaf108. Online ahead of print. PMID: 40152495
Rethinking the Semantics of "Cutaneous Squamous Cell Carcinoma In Situ". Junejo MH, Harwood CA, Ko CJ. J Cutan Pathol. 2025 May;52(5):336-338. doi: 10.1111/cup.14780. Epub 2024 Dec 30. PMID: 39739366
Topical application of the Hedgehog inhibitor patidegib in patients with Gorlin syndrome: a phase II trial. Lear JT, Harwood CA, Hasan Z, Kentley J, Thomson J, Khoo A, Alderman A, DeSouza M, Epstein EH Jr, Kochendoerfer GG, Tang JY. Br J Dermatol. 2025 Mar 18;192(4):611-617. doi: 10.1093/bjd/ljae444. PMID: 39545486
The NuRD-SWI/SNF antagonism regulates the coordinated activation of EMT and inflammation in oral cancer. Stabile R, Tucci FA, Verhagen MP, Embregts C, van den Bosch TPP, Joosten R, De Herdt MJ, van der Steen B, Nigg AL, Koljenović S, Hardillo JA, Verrijzer CP, Biddle A, Baatenburg de Jong RJ, Leenen PJM, Fodde R. J Natl Cancer Inst. 2025 Mar 18:djaf065. doi: 10.1093/jnci/djaf065. Online ahead of print. PMID: 40112045
YAP engages RIF1 to dampen replication stress in squamous cell carcinoma. Bojko J, Flynn B, Aschenbrenner B, Howard A, Lay E, Bailey E, Krajic N, Catalan C, Gallacher K, Sins E, Wang J, Jungwirth U, Lichtenberger BM, Walko G. bioRxiv 2024.12.20.629444; doi: https://doi.org/10.1101/2024.12.20.629444
Boosting Skin Wound Healing by Agrin-Mediated YAP/TAZ Activation. Jungwirth U, Walko G. J Invest Dermatol. 2025 Jan;145(1):6-8. doi: 10.1016/j.jid.2024.06.1291. Epub 2024 Sep 14. PMID: 39283286
MANIFEST: Multiomic Platform for Cancer Immunotherapy. Lim KHJ, Tippu Z, Corrie PG, Hubank M, Larkin J, Lawley TD, Stares M, Stewart GD, Strange A, Symeonides SN, Szabados B, Turner NC, Waddell T, Zelenay S, Salto-Tellez M, Dive C, Turajlic S; MANIFEST consortium. Cancer Discov. 2025 May 2;15(5):878-883. doi: 10.1158/2159-8290.CD-25-0099. PMID: 40313120
The Immunoregulatory Architecture of the Adult Oral Cavity. Fernandes Matuck B, Huynh K, Pereira D, Zhang X, Kunz M, Kumar N, Easter QT, Fernandes A, Ghodke A, Predeus A, Szabo L, Harnischfeger N, Khavandgar Z, Beach M, Perez P, Nilges B, Moreno M, Ko K, Teichmann S, Kimple A, Pringle S, Kretzschmar K, Warner BM, Sequeira I, Liu J, Byrd KM. bioRxiv [Preprint]. 2024 Dec 2:2024.12.01.626279. doi: 10.1101/2024.12.01.626279. PMID: 39677739
Transcriptome analysis of granulation tissue from periodontal osseous defects. Sam YH, Caetano AJ, Owen DR, Mainas G, Nibali L, Ghuman M. J Periodontol. 2025 May 12. doi: 10.1002/JPER.24-0821. Online ahead of print. PMID: 40351293
Protocol for detecting 3D dermal fibroblast cellular dynamics in mice using an intravital imaging technique. Hiratsuka T, Rognoni E. STAR Protoc. 2025 May 6;6(2):103801. doi: 10.1016/j.xpro.2025.103801. Online ahead of print. PMID: 40338747
Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma. Mariniello K, Pittaway JFH, Altieri B, Borges KS, Hadjidemetriou I, Ribeiro C, Ruiz-Babot G, Tourigny DS, Lim JA, Foster J, Cleaver J, Sosabowski J, Rahman N, Doroszko M, Hantel C, Sigala S, Abate A, Tamburello M, Kiseljak-Vassiliades K, Wierman M, Hall C, Parvanta L, Abdel-Aziz TE, Chung TT, Marco AD, Palazzo F, Gomez-Sanchez CE, Taylor DR, Rayner O, Ronchi CL, Gaston-Massuet C, Sbiera S, Drake WM, Rognoni E, Kroiss M, Breault DT, Fassnacht M, Guasti L. Cancer Commun (Lond). 2025 Mar 4. doi: 10.1002/cac2.70012. Online ahead of print. PMID: 40035383
SNOMED-CT and learning health systems for NHS dentistry - a dream needing to become reality. Fitzgerald R, Banerjee A, Coulthard P. Br Dent J. 2025 Jan;238(1):23-27. doi: 10.1038/s41415-024-8171-4. Epub 2025 Jan 10. PMID: 39794573
Oral disease must be central in policies to improve global health. Benzian H, Kavanaugh D, Naidoo S, Mathur MR. BMJ. 2025 May 23;389:r1070. doi: 10.1136/bmj.r1070. PMID: 40409792
India's oral health outlook: challenges, economic impact and need for preventative strategies. Narang P, Dhoble A, Mathur M, Rana S, Mason S, Ali A. Front Dent Med. 2025 Apr 9;6:1544899. doi: 10.3389/fdmed.2025.1544899. eCollection 2025. PMID: 40270521
The case for affordable oral health care: the public voice. Kaur G, Tsakos G, Yap T, King T, Mathur MR, Singh A. Public Health Res Pract. 2025 Apr;35:PU24009. doi: 10.1071/PU24009. PMID: 40456563
Population health and public health: Commonalities and differences. Bhosale AS, Urquhart O, Carrasco-Labra A, Mathur MR, Rafia K, Glick M. J Public Health Dent. 2025 Mar;85(1):40-46. doi: 10.1111/jphd.12651. Epub 2024 Dec 2. PMID: 39622770
Envisioning sustainable oral health through effective advocacy. Mathur MR, Bhosale AS, Abel SN, Fisher J, Listl S, Carrasco-Labra A, Urquhart O, Glick M. BMC Glob Public Health. 2025 Feb 19;3(1):15. doi: 10.1186/s44263-025-00133-1. PMID: 39972337
Implementation of mHealth to support cancer diagnosis in Sub-Saharan Africa: A systematic review. Arendse KD, Baby GA, Maramba TTM, Moodley J, Walter FM, Scott SE. Afr J Prim Health Care Fam Med. 2025 Mar 5;17(1):e1-e13. doi: 10.4102/phcfm.v17i1.4683. PMID: 40171699
User and Developer Views on Using AI Technologies to Facilitate the Early Detection of Skin Cancers in Primary Care Settings: Qualitative Semistructured Interview Study. Jones OT, Calanzani N, Scott SE, Matin RN, Emery J, Walter FM. JMIR Cancer. 2025 Jan 28;11:e60653. doi: 10.2196/60653. PMID: 39874580
The Combination of Oncolytic Virus and Antibody Blockade of TGF-β Enhances the Efficacy of αvβ6-Targeting CAR T Cells Against Pancreatic Cancer in an Immunocompetent Model. Zhao Z, Cutmore LC, Baleeiro RB, Hartlebury JJ, Brown N, Chard-Dunmall L, Lemoine N, Wang Y, Marshall JF. Cancers (Basel). 2025 Apr 30;17(9):1534. doi: 10.3390/cancers17091534. PMID: 40361460
TGFBI R124H mutant allele silencing in granular corneal dystrophy type 2 using topical siRNA delivery. McLain A, Kowalczyk A, Baran-Rachwalska P, Sutera FM, Robertson LJ, Nielsen NS, Enghild JJ, Cobice D, Bonelli F, Barbaro V, Ferrari S, Patterson B, Moore L, Marshall J, Nesbit MA, Moore T. J Control Release. 2025 Jun 10;382:113681. doi: 10.1016/j.jconrel.2025.113681. Epub 2025 Apr 2. PMID: 40185334
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta. Goodwin RJA; Cancer Grand Challenges Rosetta Consortium; Marshall JF, Poulogiannis G, Yuneva M, Brindle KM, Takáts Z, Sansom OJ, Bunch J, Barry ST; Cancer Grand Challenges Rosetta Consortium. Cancer Discov. 2025 Jan 13;15(1):34-38. doi: 10.1158/2159-8290.CD-24-0016. PMID: 39801233
2024:
Artificial Intelligence in Head and Neck Cancer: Innovations, Applications, and Future Directions. Pham TD, Teh MT, Chatzopoulou D, Holmes S, Coulthard P. Curr Oncol. 2024 Sep 6;31(9):5255-5290. doi: 10.3390/curroncol31090389. PMID: 39330017
Development of an in vitro microfluidic model to study the role of microenvironmental cells in oral cancer metastasis. Scemama A, Lunetto S, Tailor A, Di Cio S, Dibble M, Gautrot J, Biddle A. F1000Res. 2024 Jan 15;12:439. doi: 10.12688/f1000research.131810.2. eCollection 2023. PMID: 38434654
Skin cancers are the most frequent cancers in fair-skinned populations, but we can prevent them. Garbe C, Forsea AM, Amaral T, Arenberger P, Autier P, Berwick M, Boonen B, Bylaite M, Del Marmol V, Dreno B, Fargnoli MC, Geller AC, Green AC, Greinert R, Hauschild A, Harwood CA, Hoorens I, Kandolf L, Kaufmann R, Kelleners-Smeets N, Lallas A, Lebbé C, Leiter U, Lim HW, Longo C, Malvehy J, Moreno D, Pellacani G, Peris K, Robert C, Saiag P, Schadendorf D, Peter Soyer H, Stockfleth E, Stratigos A, Uhara H, Vieira R, Volkmer B, Weinstock MA, Whitaker D, Zalaudek I, Whiteman DC, Brochez L. Eur J Cancer. 2024 Jun;204:114074. doi: 10.1016/j.ejca.2024.114074. Epub 2024 Apr 24. PMID: 38691877
European consensus-based interdisciplinary guideline for diagnosis, treatment and prevention of actinic keratoses, epithelial UV-induced dysplasia and field cancerization on behalf of European Association of Dermato-Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes). Kandolf L, Peris K, Malvehy J, Mosterd K, Heppt MV, Fargnoli MC, Berking C, Arenberger P, Bylaite-Bučinskiene M, Del Marmol V, Dirschka T, Dreno B, Forsea AM, Harwood CA, Hauschild A, Heerfordt IM, Kauffman R, Kelleners-Smeets N, Lallas A, Lebbe C, Leiter U, Longo C, Mijušković Ž, Pellacani G, Puig S, Saiag P, Šitum M, Stockfleth E, Salavastru C, Stratigos A, Zalaudek I, Garbe C; European Association of Dermato‐Oncology, European Dermatology Forum, European Academy of Dermatology and Venereology and Union of Medical Specialists (Union Européenne des Médecins Spécialistes). J Eur Acad Dermatol Venereol. 2024 Jun;38(6):1024-1047. doi: 10.1111/jdv.19897. Epub 2024 Mar 7. PMID: 38451047
Cumulative incidence and risk factors for cutaneous squamous cell carcinoma metastases in organ transplant recipients: The Skin Care in Organ Transplant Patients in Europe-International Transplant Skin Cancer Collaborative metastases study, a prospective multicenter study. de Jong E, Genders R, Harwood CA, Green AC, Plasmeijer EI, Proby C, Geissler E, Ferrándiz-Pulido C, Ducroux E, Euvrard S, Geusau A, Jahn-Bassler K, Borik-Heil L, Rácz E, Nägeli M, Hofbauer GFL, Piaserico S, Russo I, Mackintosh L, Borges-Costa J, Angeliki-Gkini M, Zavattaro E, Savoia P, Imko-Walszuk B, Dębska-Slizień A, Garmyn M, van Kelst S, Ricar J, Cetkovska P, Matin R, Güleç AT, Seçkin D, Anene CA, Oliveira WRP, Rademaker M, Goeman J, van Geloven N, Ruiz E, Murad F, Karn E, Schmults CD, Bouwes Bavinck JN. J Am Acad Dermatol. 2024 Jun;90(6):1200-1209. doi: 10.1016/j.jaad.2024.01.040. Epub 2024 Feb 1. PMID: 38301923
Is the presence of Merkel cell polyomavirus and human papillomavirus DNA in keratinocyte cancers and precancers associated with HIV status? A case-control study. Goolamali SI, Shim TN, Purdie K, Mladkova N, Francis N, Harwood CA, Bunker CB. Clin Exp Dermatol. 2024 Feb 14;49(3):263-266. doi: 10.1093/ced/llad336. PMID: 37793080
Generation of 3D Fibroblast-Derived Extracellular Matrix and Analysis of Tumor Cell-Matrix Interactions and Signaling. Lay E, Grant T, Walko G, Jungwirth U. Methods Mol Biol. 2024;2800:11-25. doi: 10.1007/978-1-0716-3834-7_2. PMID: 38709474
Cell-vision fusion: A Swin transformer-based approach for predicting kinase inhibitor mechanism of action from Cell Painting data. Dee W, Sequeira I, Lobley A, Slabaugh G. iScience. 2024 Jul 15;27(8):110511. doi: 10.1016/j.isci.2024.110511. eCollection 2024 Aug 16. PMID: 39175778
Single-cell and spatially resolved interactomics of tooth-associated keratinocytes in periodontitis. Easter QT, Fernandes Matuck B, Beldorati Stark G, Worth CL, Predeus AV, Fremin B, Huynh K, Ranganathan V, Ren Z, Pereira D, Rupp BT, Weaver T, Miller K, Perez P, Hasuike A, Chen Z, Bush M, Qu X, Lee J, Randell SH, Wallet SM, Sequeira I, Koo H, Tyc KM, Liu J, Ko KI, Teichmann SA, Byrd KM. Nat Commun. 2024 Jun 14;15(1):5016. doi: 10.1038/s41467-024-49037-y. PMID: 38876998
Computational Methods for Image Analysis in Craniofacial Development and Disease. James E, Caetano AJ, Sharpe PT. J Dent Res. 2024 Dec;103(13):1340-1348. doi: 10.1177/00220345241265048. Epub 2024 Sep 13. PMID: 39272216
The RNA binding proteins LARP4A and LARP4B promote sarcoma and carcinoma growth and metastasis. Coleman JC, Tattersall L, Yianni V, Knight L, Yu H, Hallett SR, Johnson P, Caetano AJ, Cosstick C, Ridley AJ, Gartland A, Conte MR, Grigoriadis AE. iScience. 2024 Feb 24;27(4):109288. doi: 10.1016/j.isci.2024.109288. eCollection 2024 Apr 19. PMID: 38532886
Redefining Mucosal Inflammation with Spatial Genomics. Caetano AJ, Sharpe PT. J Dent Res. 2024 Feb;103(2):129-137. doi: 10.1177/00220345231216114. Epub 2024 Jan 3. PMID: 38166489
Weekly Intraperitoneal Injection of Tamoxifen in an Inducible In Vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes. Jones EM, Garcha P, Aumailley M, O'Toole EA, Rognoni E, Caley M. JID Innov. 2024 Nov 22;5(2):100331. doi: 10.1016/j.xjidi.2024.100331. eCollection 2025 Mar. PMID: 39811761
Erosive lichen planus: an unmet disease burden. Macken JH, Senusi A, O'Toole EA, Caley M, Rognoni E, Fortune F. Front Med (Lausanne). 2024 Oct 17;11:1457667. doi: 10.3389/fmed.2024.1457667. eCollection 2024. PMID: 39484200
Lipid Nanoparticles Efficiently Deliver the Base Editor ABE8e for COL7A1 Correction in Dystrophic Epidermolysis Bullosa Fibroblasts In Vitro. Guri-Lamce I, Alrokh Y, Graham C, Maeshima R, Rognoni E, Caley M, Łaczmański Ł, Hart SL, McGrath JA, Jacków-Malinowska J. J Invest Dermatol. 2024 Oct;144(10):2314-2317.e3. doi: 10.1016/j.jid.2024.03.027. Epub 2024 Apr 5. PMID: 38583743
Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Bailey P, Ridgway RA, Cammareri P, Treanor-Taylor M, Bailey UM, Schoenherr C, Bone M, Schreyer D, Purdie K, Thomson J, Rickaby W, Jackstadt R, Campbell AD, Dimonitsas E, Stratigos AJ, Arron ST, Wang J, Blyth K, Proby CM, Harwood CA, Sansom OJ, Leigh IM, Inman GJ. Nat Commun. 2023 Aug 25;14(1):5211. doi: 10.1038/s41467-023-40822-9. PMID: 37626054
Immunotherapy that improves response to chemotherapy in high-grade serous ovarian cancer. Elorbany S, Berlato C, Carnevalli LS, Maniati E, Barry ST, Wang J, Manchanda R, Kzhyshkowska J, Balkwill F. Nat Commun. 2024 Nov 22;15(1):10144. doi: 10.1038/s41467-024-54295-x. PMID: 39578450
The integrated molecular and histological analysis defines subtypes of esophageal squamous cell carcinoma. Jiang G, Wang Z, Cheng Z, Wang W, Lu S, Zhang Z, Anene CA, Khan F, Chen Y, Bailey E, Xu H, Dong Y, Chen P, Zhang Z, Gao D, Wang Z, Miao J, Xue X, Wang P, Zhang L, Gangeswaran R, Liu P, Chard Dunmall LS, Li J, Guo Y, Dong J, Lemoine NR, Li W, Wang J, Wang Y. Nat Commun. 2024 Oct 18;15(1):8988. doi: 10.1038/s41467-024-53164-x. PMID: 39419971
Lineage specification in glioblastoma is regulated by METTL7B. Constantinou M, Nicholson J, Zhang X, Maniati E, Lucchini S, Rosser G, Vinel C, Wang J, Lim YM, Brandner S, Nelander S, Badodi S, Marino S. Cell Rep. 2024 Jun 25;43(6):114309. doi: 10.1016/j.celrep.2024.114309. Epub 2024 Jun 5. PMID: 38848215
Impact of edentulism on community-dwelling adults in low-income, middle-income and high-income countries: a systematic review. Hunter E, De Moura Brito L, Piyasena P, Petrauskiene E, Congdon N, Tsakos G, Virgili G, Mathur M, Woodside JV, Leles C, McKenna G. BMJ Open. 2024 Dec 4;14(12):e085479. doi: 10.1136/bmjopen-2024-085479. PMID: 39632108
Making the case for a new typology of dental care systems. Guarnizo-Herreño CC, Singh A, Mathur MR, Sarawagi S, Peres MA. Community Dent Oral Epidemiol. 2024 Dec;52(6):767-774. doi: 10.1111/cdoe.12992. Epub 2024 Jul 10. PMID: 38984774
Assessment of Oral Health Status, Care Seeking Behaviours, and Oral Health-Related Quality of Life among Indian Adults Using the World Dental Federation's Digital Application. Balraj L, Oswal KC, Reddy RBV, Kunjan PD, Chandu VC, Mathur MR. Indian J Dent Res. 2024 Oct 1;35(4):390-394. doi: 10.4103/ijdr.ijdr_423_24. Epub 2025 Feb 24. PMID: 40008844
Political economy analysis of health: a scoping review protocol. Karuveettil V, Janakiram C, John D, Mathur M, Varma B, Green H. JBI Evid Synth. 2024 Sep 1;22(9):1906-1913. doi: 10.11124/JBIES-23-00204. PMID: 3874547
Global burden of 288 causes of death and life expectancy decomposition in 204 countries and territories and 811 subnational locations, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021. GBD 2021 Causes of Death Collaborators. Lancet. 2024 May 18;403(10440):2100-2132. doi: 10.1016/S0140-6736(24)00367-2. Epub 2024 Apr 3. PMID: 38582094
Assessing the status of oral health integration in South East Asian Regional Office countries' Universal Health Coverage-A scoping review. Acharya S, Mathur MR, Tadakamadla SK, Brand A. Int J Health Plann Manage. 2024 Mar;39(2):262-277. doi: 10.1002/hpm.3751. Epub 2024 Jan 3. PMID: 38169038
Temporal patterns of cancer burden in Asia, 1990-2019: a systematic examination for the Global Burden of Disease 2019 study. GBD 2019 Asia and All Cancers Collaborators. Lancet Reg Health Southeast Asia. 2024 Jan 2;21:100333. doi: 10.1016/j.lansea.2023.100333. eCollection 2024 Feb. PMID: 38361599
Acceptability of de-intensified screening for women at low risk of breast cancer: a randomised online experimental survey. Kelley-Jones C, Scott SE, Waller J. BMC Cancer. 2024 Sep 6;24(1):1111. doi: 10.1186/s12885-024-12847-w. PMID: 39243000
Advice after urgent suspected cancer referral when cancer is not found in England: Survey of patients' preferences and perceived acceptability. E C Evans R, Watson H, Waller J, Nicholson BD, Round T, Gildea C, Smith D, Scott SE. Prev Med Rep. 2024 Jun 10;43:102781. doi: 10.1016/j.pmedr.2024.102781. eCollection 2024 Jul. PMID: 38975283
Risk-Adapted Breast Screening for Women at Low Predicted Risk of Breast Cancer: An Online Discrete Choice Experiment. Kelley Jones C, Scott S, Pashayan N, Morris S, Okan Y, Waller J. Med Decis Making. 2024 Jul;44(5):586-600. doi: 10.1177/0272989X241254828. Epub 2024 Jun 3. PMID: 38828503
Understanding GPs' referral decisions for younger patients with symptoms of cancer: a qualitative interview study. di Martino E, Honey S, Bradley SH, Ali OM, Neal RD, Scott SE. Br J Gen Pract. 2024 May 30;74(743):e387-e392. doi: 10.3399/BJGP.2023.0304. Print 2024 Jun. PMID: 38684377
"Notification! You May Have Cancer." Could Smartphones and Wearables Help Detect Cancer Early? Scott SE, Thompson MJ. JMIR Cancer. 2024 May 20;10:e52577. doi: 10.2196/52577. PMID: 38767941
Integrin-αvβ6 targeted peptide-toxin therapy in a novel αvβ6-expressing immunocompetent model of pancreatic cancer. Brown NF, Murray ER, Cutmore LC, Howard P, Masterson L, Zammarchi F, Hartley JA, van Berkel PH, Marshall JF. Pancreatology. 2024 May;24(3):445-455. doi: 10.1016/j.pan.2024.02.013. Epub 2024 Feb 24. PMID: 38519394
A trafficking regulatory subnetwork governs αVβ6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance. Maldonado H, Dreger M, Bedgood LD, Kyriakou T, Wolanska KI, Rigby ME, Marotta VE, Webster JM, Wang J, Rusilowicz-Jones EV, Marshall JF, Coulson JM, Macpherson IR, Hurlstone A, Morgan MR. Sci Adv. 2024 Dec 6;10(49):eadk9944. doi: 10.1126/sciadv.adk9944. Epub 2024 Dec 4. PMID: 39630893
Syngeneic Mouse Models for Pre-Clinical Evaluation of CAR T Cells. Ahmed EN, Cutmore LC, Marshall JF. Cancers (Basel). 2024 Sep 18;16(18):3186. doi: 10.3390/cancers16183186. PMID: 39335157
2023:
Disseminating cells in human oral tumours possess an EMT cancer stem cell marker profile that is predictive of metastasis in image-based machine learning. Youssef G, Gammon L, Ambler L, Lunetto S, Scemama A, Cottom H, Piper K, Mackenzie IC, Philpott MP, Biddle A. Elife. 2023 Nov 17;12:e90298. doi: 10.7554/eLife.90298. PMID: 37975646
CD73 controls Myosin II-driven invasion, metastasis, and immunosuppression in amoeboid pancreatic cancer cells. Samain R, Maiques O, Monger J, Lam H, Candido J, George S, Ferrari N, KohIhammer L, Lunetto S, Varela A, Orgaz JL, Vilardell F, Olsina JJ, Matias-Guiu X, Sarker D, Biddle A, Balkwill FR, Eyles J, Wilkinson RW, Kocher HM, Calvo F, Wells CM, Sanz-Moreno V. Sci Adv. 2023 Oct 20;9(42):eadi0244. doi: 10.1126/sciadv.adi0244. Epub 2023 Oct 18. PMID: 37851808
In vitro cancer models as an approach to identify targetable developmental phenotypes in cancer stem cells. Biddle A. In Vitro Model. 2023;2(3-4):83-88. doi: 10.1007/s44164-023-00051-2. Epub 2023 May 12. PMID: 37808201
Lrig1-expression confers suppressive function to CD4+ cells and is essential for averting autoimmunity via the Smad2/3/Foxp3 axis. Moon JS, Ho CC, Park JH, Park K, Shin BY, Lee SH, Sequeira I, Mun CH, Shin JS, Kim JH, Kim BS, Noh JW, Lee ES, Son JY, Kim Y, Lee Y, Cho H, So S, Park J, Choi E, Oh JW, Lee SW, Morio T, Watt FM, Seong RH, Lee SK. Nat Commun. 2023 Sep 4;14(1):5382. doi: 10.1038/s41467-023-40986-4. PMID: 37666819
Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10. Caetano AJ, Redhead Y, Karim F, Dhami P, Kannambath S, Nuamah R, Volponi AA, Nibali L, Booth V, D'Agostino EM, Sharpe PT. Elife. 2023 Jan 17;12:e81525. doi: 10.7554/eLife.81525. PMID: 36648332
Preparation and Use of shRNA for Knocking Down Specific Genes. Jamal A, Usman S, Teh MT, Waseem A. Methods Mol Biol. 2024;2849:55-72. doi: 10.1007/7651_2024_515. PMID: 38411888
Site-Directed Mutagenesis to Mutate Multiple Residues in a Single Reaction. Usman S, Bushaala A, Teh MT, Waseem A. Methods Mol Biol. 2024;2849:123-133. doi: 10.1007/7651_2023_511. PMID: 38180689
Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells. Wan H, Teh MT, Mastroianni G, Ahmad US. Cells. 2023 Nov 26;12(23):2710. doi: 10.3390/cells12232710. PMID: 38067138
Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells. Khera N, Rajkumar AS, Abdulkader M Alkurdi K, Liu Z, Ma H, Waseem A, Teh MT. Mol Cancer. 2023 Sep 4;22(1):146. doi: 10.1186/s12943-023-01846-3. PMID: 37667354
The Effect of Remote Digital Services on Health Care Inequalities Among People Under Long-Term Dermatology Follow-Up: Cross-Sectional Questionnaire Study. Ramjee S, Mohamedthani H, Patel AU, Goiriz R, Harwood CA, Osborne RH, Cheng C, Hasan ZU. JMIR Dermatol. 2023 Dec 8;6:e48981. doi: 10.2196/48981. PMID: 38064259
Cutaneous Squamous Cell Cancer on the Waistline Associated with Saree-wearing: A Case Report and Literature Review. Cernova J, Junejo MH, Ligaj M, Hussain F, Harwood CA. Acta Derm Venereol. 2023 Nov 28;103:adv11970. doi: 10.2340/actadv.v103.11970. PMID: 38014830
European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma. Part 1: Diagnostics and prevention-Update 2023. Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, van Akkooi A, Bataille V, Bastholt L, Dreno B, Dummer R, Fargnoli MC, Forsea AM, Harwood CA, Hauschild A, Hoeller C, Kandolf-Sekulovic L, Kaufmann R, Kelleners-Smeets NW, Lallas A, Leiter U, Malvehy J, Del Marmol V, Moreno-Ramirez D, Pellacani G, Peris K, Saiag P, Tagliaferri L, Trakatelli M, Ioannides D, Vieira R, Zalaudek I, Arenberger P, Eggermont AMM, Röcken M, Grob JJ, Lorigan P; EADO, EDF, ESTRO, UEMS, EADV and EORTC. Eur J Cancer. 2023 Nov;193:113251. doi: 10.1016/j.ejca.2023.113251. Epub 2023 Jul 28. PMID: 37717283
European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma: Part 2. Treatment-Update 2023. Stratigos AJ, Garbe C, Dessinioti C, Lebbe C, van Akkooi A, Bataille V, Bastholt L, Dreno B, Dummer R, Fargnoli MC, Forsea AM, Harwood CA, Hauschild A, Hoeller C, Kandolf-Sekulovic L, Kaufmann R, Kelleners-Smeets NW, Lallas A, Leiter U, Malvehy J, Del Marmol V, Moreno-Ramirez D, Pellacani G, Peris K, Saiag P, Tagliaferri L, Trakatelli M, Ioannides D, Vieira R, Zalaudek I, Arenberger P, Eggermont AMM, Röcken M, Grob JJ, Lorigan P; EADO, EDF, ESTRO, UEMS, EADV and EORTC. Eur J Cancer. 2023 Nov;193:113252. doi: 10.1016/j.ejca.2023.113252. Epub 2023 Jul 28. PMID: 37708630
Driver gene combinations dictate cutaneous squamous cell carcinoma disease continuum progression. Bailey P, Ridgway RA, Cammareri P, Treanor-Taylor M, Bailey UM, Schoenherr C, Bone M, Schreyer D, Purdie K, Thomson J, Rickaby W, Jackstadt R, Campbell AD, Dimonitsas E, Stratigos AJ, Arron ST, Wang J, Blyth K, Proby CM, Harwood CA, Sansom OJ, Leigh IM, Inman GJ. Nat Commun. 2023 Aug 25;14(1):5211. doi: 10.1038/s41467-023-40822-9. PMID: 37626054
European consensus-based interdisciplinary guideline for diagnosis and treatment of basal cell carcinoma-update 2023. Peris K, Fargnoli MC, Kaufmann R, Arenberger P, Bastholt L, Seguin NB, Bataille V, Brochez L, Del Marmol V, Dummer R, Forsea AM, Gaudy-Marqueste C, Harwood CA, Hauschild A, Höller C, Kandolf L, Kellerners-Smeets NWJ, Lallas A, Leiter U, Malvehy J, Marinović B, Mijuskovic Z, Moreno-Ramirez D, Nagore E, Nathan P, Stratigos AJ, Stockfleth E, Tagliaferri L, Trakatelli M, Vieira R, Zalaudek I, Garbe C; EADO”A, EDF”B, ESTRO”C, UEMS”D and EADV”E. Eur J Cancer. 2023 Oct;192:113254. doi: 10.1016/j.ejca.2023.113254. Epub 2023 Jul 28. PMID: 37604067
Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis. Wang J, Harwood CA, Bailey E, Bewicke-Copley F, Anene CA, Thomson J, Qamar MJ, Laban R, Nourse C, Schoenherr C, Treanor-Taylor M, Healy E, Lai C, Craig P, Moyes C, Rickaby W, Martin J, Proby C, Inman GJ, Leigh IM. J Am Acad Dermatol. 2023 Dec;89(6):1159-1166. doi: 10.1016/j.jaad.2023.08.012. Epub 2023 Aug 14. PMID: 37586461
Cutaneous manifestations induced by check point inhibitors in 120 melanoma patients-The European MelSkinTox study. L'Orphelin JM, Cassecuel J, Kandolf L, Harwood CA, Tookey P, Junejo MH, Hogan S, Lebbé C, Appalla Z, Kränke TM, Pellacani G, Cerasuolo D, Dujovic B, Del Marmol V, Forschner A, Garbe C, Bataille V, Ressler JM, Sollena P, Dompmartin A, Peris K, Dreno B; And European Association of Dermato-Oncology. J Eur Acad Dermatol Venereol. 2023 Apr 12. doi: 10.1111/jdv.19112. Online ahead of print. PMID: 37042810
'Get Data Out' Skin: national cancer registry incidence and survival rates for all registered skin tumour groups for 2013-2019 in England. van Bodegraven B, Vernon S, Eversfield C, Board R, Craig P, Gran S, Harwood CA, Keohane S, Levell NJ, Matin RN, Proby C, Rajan N, Rous B, Ascott A, Millington GWM, Venables ZC; British Association of Dermatologists National Disease Registration Service Steering Committee. Br J Dermatol. 2023 May 24;188(6):777-784. doi: 10.1093/bjd/ljad033. PMID: 36814132
Variation in management of porocarcinoma: a 10-year retrospective review of 75 cases across three UK tertiary centres. Winn RT, Gazzani P, Venables ZC, Shah F, Gkini M, Jeetle S, Oliphant T, Wijesuriya N, Martin-Clavijo A, Husain A, Harwood CA, Rajan N. Clin Exp Dermatol. 2023 Feb 2;48(2):121-124. doi: 10.1093/ced/llac052. PMID: 36730509
CorrespondenceShort shock or slow burn? Patient perspectives on treatment of actinic keratoses with 5-fluorouracil 5% cream monotherapy versus 5-fluorouracil plus calcipotriol combination therapy. Junejo MH, Demirel S, Matin R, Proby C, Harwood CA. Clin Exp Dermatol. 2023 Jan 20;48(1):31-32. doi: 10.1093/ced/llac011. PMID: 36669179
Investigating iRHOM2-Associated Transcriptional Changes in Tylosis With Esophageal Cancer. Murtough S, Babu D, Webb CM, Louis Dit Picard H, McGinty LA, Chao-Chu J, Pink R, Silver AR, Smart HL, Field JK, Woodland P, Risk JM, Blaydon DC, Pennington DJ, Kelsell DP. Gastro Hep Adv. 2023 Dec 26;3(3):385-395. doi: 10.1016/j.gastha.2023.12.007. eCollection 2024. PMID: 3913115
Skin fibroblast functional heterogeneity in health and disease. Bensa T, Tekkela S, Rognoni E. J Pathol. 2023 Aug;260(5):609-620. doi: 10.1002/path.6159. Epub 2023 Aug 8. PMID: 37553730
The Global, Regional, and National Burden of Adult Lip, Oral, and Pharyngeal Cancer in 204 Countries and Territories: A Systematic Analysis for the Global Burden of Disease Study 2019. GBD 2019 Lip, Oral, and Pharyngeal Cancer Collaborators; Cunha ARD, Compton K, Xu R, Mishra R, Drangsholt MT, Antunes JLF, Kerr AR, Acheson AR, Lu D, Wallace LE, Kocarnik JM, Fu W, Dean FE, Pennini A, Henrikson HJ, Alam T, Ababneh E, Abd-Elsalam S, Abdoun M, Abidi H, Abubaker Ali H, Abu-Gharbieh E, Adane TD, Addo IY, Ahmad A, Ahmad S, Ahmed Rashid T, Akonde M, Al Hamad H, Alahdab F, Alimohamadi Y, Alipour V, Al-Maweri SA, Alsharif U, Ansari-Moghaddam A, Anwar SL, Anyasodor AE, Arabloo J, Aravkin AY, Aruleba RT, Asaad M, Ashraf T, Athari SS, Attia S, Azadnajafabad S, Azangou-Khyavy M, Badar M, Baghcheghi N, Banach M, Bardhan M, Barqawi HJ, Bashir NZ, Bashiri A, Benzian H, Bernabe E, Bhagat DS, Bhojaraja VS, Bjørge T, Bouaoud S, Braithwaite D, Briko NI, Calina D, Carreras G, Chakraborty PA, Chattu VK, Chaurasia A, Chen MX, Cho WCS, Chu DT, Chukwu IS, Chung E, Cruz-Martins N, Dadras O, Dai X, Dandona L, Dandona R, Daneshpajouhnejad P, Darvishi Cheshmeh Soltani R, Darwesh AM, Debela SA, Derbew Molla M, Dessalegn FN, Dianati-Nasab M, Digesa LE, Dixit SG, Dixit A, Djalalinia S, El Sayed I, El Tantawi M, Enyew DB, Erku DA, Ezzeddini R, Fagbamigbe AF, Falzone L, Fetensa G, Fukumoto T, Gae… See abstract for full author list ➔ JAMA Oncol. 2023 Oct 1;9(10):1401-1416. doi: 10.1001/jamaoncol.2023.2960. PMID: 37676656
Prescription patterns of analgesics for oral conditions in india - Analysis of large medical audit data of outpatients in India's private healthcare sector. Sayeed S, Mathur MR, Mishra VK, Nagrath D, Watt RG. Indian J Dent Res. 2023 Jul-Sep;34(3):278-283. doi: 10.4103/ijdr.ijdr_104_23. PMID: 38197347
Antibiotic prescriptions for oral diseases in India: evidence from national prescription data. Mathur MR, Nagrath D, Mishra VK, Harris R, Saeed SS, Selvaraj S, Mehta A, Farooqui HH. BMC Oral Health. 2023 Mar 25;23(1):170. doi: 10.1186/s12903-023-02889-0. PMID: 36966284
Transcriptomic analysis of cutaneous squamous cell carcinoma reveals a multigene prognostic signature associated with metastasis. Wang J, Harwood CA, Bailey E, Bewicke-Copley F, Anene CA, Thomson J, Qamar MJ, Laban R, Nourse C, Schoenherr C, Treanor-Taylor M, Healy E, Lai C, Craig P, Moyes C, Rickaby W, Martin J, Proby C, Inman GJ, Leigh IM. J Am Acad Dermatol. 2023 Dec;89(6):1159-1166. doi: 10.1016/j.jaad.2023.08.012. Epub 2023 Aug 14. PMID: 37586461
Inflammation induced by tumor-associated nerves promotes resistance to anti-PD-1 therapy in cancer patients and is targetable by interleukin-6 blockade. Baruch EN, Nagarajan P, Gleber-Netto FO, Rao X, Xie T, Akhter S, Adewale A, Shajedul I, Mattson BJ, Ferrarotto R, Wong MK, Davies MA, Jindal S, Basu S, Harwood C, Leigh I, Ajami N, Futreal A, Castillo M, Gunaratne P, Goepfert RP, Khushalani N, Wang J, Watowich S, Calin GA, Migden MR, Vermeer P, D'Silva N, Yaniv D, Burks JK, Gomez J, Dougherty PM, Tsai KY, Allison JP, Sharma P, Wargo J, Myers JN, Gross ND, Amit M. Res Sq [Preprint]. 2023 Jul 18:rs.3.rs-3161761. doi: 10.21203/rs.3.rs-3161761/v1. PMID: 37503252
Personalized neoantigen viro-immunotherapy platform for triple-negative breast cancer. Brito Baleeiro R, Liu P, Chard Dunmall LS, Di Gioia C, Nagano A, Cutmore L, Wang J, Chelala C, Nyambura LW, Walden P, Lemoine N, Wang Y. J Immunother Cancer. 2023 Aug;11(8):e007336. doi: 10.1136/jitc-2023-007336. PMID: 37586771
Future cancer risk after urgent suspected cancer referral in England when cancer is not found: a national cohort study. Scott SE, Gildea C, Nicholson BD, Evans RE, Waller J, Smith D, Purushotham A, Round T. Lancet Oncol. 2023 Nov;24(11):1242-1251. doi: 10.1016/S1470-2045(23)00435-7. PMID: 37922929
Talking about cancer: Patient responses to raising awareness of oral cancer in primary dental care. Scott SE, Bruj G, Beheshti S, Evans R, Awojobi O. Community Dent Oral Epidemiol. 2023 Oct;51(5):887-895. doi: 10.1111/cdoe.12783. Epub 2022 Aug 14. PMID: 35964230
Single-centre, single-blinded, randomised, parallel group, feasibility study protocol investigating if mandibular advancement device treatment for obstructive sleep apnoea can reduce nocturnal gastro-oesophageal reflux (MAD-Reflux trial). O'Toole S, Moazzez R, Wojewodka G, Zeki S, Jafari J, Hope K, Brand A, Hoare Z, Scott S, Doungsong K, Ezeofor V, Edwards RT, Drakatos P, Steier J. BMJ Open. 2023 Aug 24;13(8):e076661. doi: 10.1136/bmjopen-2023-076661. PMID: 37620257
Patients' views on the decision to investigate cancer symptoms in older adults: a qualitative interview study in primary care. Jones D, Ali OM, Honey S, Surr C, Scott S, De Wit N, Neal RD. Br J Gen Pract. 2023 Jul 27;73(733):e597-e604. doi: 10.3399/BJGP.2022.0622. Print 2023 Aug. PMID: 37365009
Should we? Could we? Feasibility of interventions to support prevention or early diagnosis of future cancer following urgent referral: A qualitative study. Evans REC, Waller J, Nicholson BD, Round T, Gildea C, Smith D, Scott SE. Patient Educ Couns. 2023 Jul;112:107757. doi: 10.1016/j.pec.2023.107757. Epub 2023 Apr 14. PMID: 37099888
Real time improvement in head and neck cancer outcomes: The community psychiatric nurse. Miller BJ, Price S, Scott SE, Oakley R. Clin Otolaryngol. 2023 May;48(3):495-496. doi: 10.1111/coa.14030. Epub 2023 Jan 15. PMID: 36624681
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression. Gibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, Auf dem Keller U, Agnoletto A, Brisken C, Peck B, Cameron AJ, Marshall JF, Jones JL, Carter EP, Grose RP. NPJ Breast Cancer. 2023 Mar 2;9(1):9. doi: 10.1038/s41523-023-00513-6. PMID: 36864079
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Deep palmar phenotyping in atopic eczema: patterns associated with Filaggrin variants, disease severity and barrier function in a South Asian population. Thomas BR, Tan XL, Van Duijvenboden S, Hogan SC, Hughes AJ, Tawfik SS, Dhoat S, Atkar R, Robinson EJ, Rahman SR, Rahman S, Ahmed RA, Begum R, Khanam H, Bourne EL, Wozniak EL, Mein CA, Kelsell DP, O'Toole EA. Br J Dermatol. 2023 Feb 25:ljad036. doi: 10.1093/bjd/ljad036.
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Assessing performance of the Healthcare Access and Quality Index, overall and by select age groups, for 204 countries and territories, 1990–2019: a systematic analysis from the Global Burden of Disease Study 2019. Global Burden of Disease Study 2019, Healthcare Access and Quality, Collaborators:, Dandona L, Dandona R, Golechha M, Kumar GA, Mathur MR. Lancet Glob Health. 2022;-(-):[Epub ahead of print]
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Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion. Hayward MK, Allen MD, Gomm JJ et al, Marshall JF. npj Breast Cancer (2022) 8(7)
Ligand-bound integrin αvβ6 internalisation and trafficking. Meecham A, Cutmore LC, Protopapa P et al., Marshall JF. Frontiers in Cell and Developmental Biology (2022) 10(7)
Synthesis and Systematic Study on the Effect of Different PEG Units on Stability of PEGylated, Integrin-αvβ6-Specific A20FMDV2 Analogues in Rat Serum and Human Plasma. Hung KY, Kowalczyk R, Desai A et al., Marshall JF. Molecules (2022) 27(7)
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion. Murray ER, Menezes S, Henry JC et al., Wang J, Marshall JF. Cell Reports (2022) 38(7)
Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin av beta 6-targeting peptide-drug conjugate. Murray ER, Brown NF, Howard P et al., Marshall JF. CANCER RESEARCH (2021) 81(11)
Current perspectives on the use of off the shelf car-t/nk cells for the treatment of cancer. Cutmore LC, Marshall JF Cancers (2021) 13(7)
CEACAM7 is an effective target for CAR T-cell therapy of pancreatic ductal adenocarcinoma. Raj D, Nikolaidi M, Garces I et al., Marshall JF. Clinical Cancer Research (2021) 27(7) 1538-1552
IBRAP: integrated benchmarking single-cell RNA-sequencing analytical pipeline. Knight CH, Khan F, Patel A et al., Wang J. Brief Bioinform (2023) (2)
Replication stress generates distinctive landscapes of DNA copy number alterations and chromosome scale losses.Shaikh N, Mazzagatti A, De Angelis S et al., Wang J. Genome Biology (2022) 23(7)
Characterization of the Intra-tumoral B Cell Immunoglobulin Repertoire Is of Prognostic Value for Esophageal Squamous Cell Carcinoma. Wang Z, Cheng Z, Lu S, Chard Dunmall LS, Wang J, Guo Y, Wang Y (2022). Frontiers in Immunology vol. 13, 10.3389/fimmu.2022.896627