Dr Vineesh Kappadan

Profile

Vineesh Kappadan is a Lecturer in Biomedical Signal Processing at Queen Mary University of London. His background is in applied physics, biomedical optics, and biomedical signal processing, with a particular interest in computational approaches to biomedical research.

Vineesh completed his PhD in Physics at the University of Goettingen and subsequently carried out postdoctoral research at Imperial College London. His academic experience combines experimental physics, biomedical imaging, and quantitative data analysis. He has a strong experimental background in fluorescence imaging, excitation and emission ratiometry, cardiac optical mapping, and electrophysiological measurements.

Vineesh’s computational expertise includes digital signal processing, spectral analysis, image registration, motion correction, and spatiotemporal data analysis. He develops and applies computational methods using Python and MATLAB to analyse complex biomedical signals and images, improve measurement reliability, and extract meaningful information from physiological recordings.

Teaching

Fundamentals of DSP-QHE5107

This course covers the fundamentals of digital signal processing, including discrete-time signals and systems, convolution, and frequency-domain analysis. Students will learn about key techniques such as the Discrete-Time Fourier Transform (DTFT), Discrete Fourier Transform (DFT), Fast Fourier Transform (FFT), and Z-transform. The course also introduces digital filter design, including FIR and IIR filters, with practical examples and exercises to help students understand how these techniques are used to analyse and process signals.

Research

Research Interests:

Vineesh's research focuses on developing and evaluating computational approaches to improve the reliability and interpretation of physiological measurements, with a particular interest in cardiac electrophysiology and arrhythmias.

During his PhD, Vineesh investigated methods to minimise motion artefacts in cardiac optical mapping and compared electrophysiological measurements from contracting and non-contracting hearts. This work aimed to understand how mechanical contraction affects optical recordings and to improve the accuracy of measurements obtained from beating hearts.

His postdoctoral research focused on developing and validating motion artefact reduction methods by combining image registration with fluorescence emission ratiometry. He validated these methods by comparing corrected optical action potential measurements with simultaneously recorded electrical measurements. His research also involved the analysis of cardiac electrophysiological recordings under different experimental conditions.

Vineesh's current research is primarily computational, focusing on the analysis of electrocardiograms (ECGs), electrograms, and optical action potential recordings. He is particularly interested in investigating the spatial and temporal characteristics of cardiac arrhythmias, assessing signal quality, and understanding how measurement artefacts influence the interpretation of electrophysiological activity.

His broader research interests include developing robust analytical approaches, evaluating the reliability of existing methods, and exploring their applications across different experimental datasets and physiological conditions. Vineesh aims to improve the quality and interpretation of biomedical data through reliable and reproducible computational methods.

Examples of research funding:

Vineesh’s postdoctoral research was supported by funding from the British Heart Foundation (BHF), awarded to the project's Principal Investigator (PI). He contributed to the research activities undertaken as part of this funded project.

Publications

• Vineesh Kappadan*, Zhen Hua*, Johanna B. Tonko, et al. "Combined Emission Ratiometry and Motion Tracking for Optical Mapping of Contracting Hearts: Validation with Monophasic Action Potentials", Journal of Physiology. 2026.
• Vineesh Kappadan*, Zhen Hua*, Paraskevas Efstathiou*, et al. "Differential response to acute ischemia between isolated contracting hearts and hearts perfused with excitation-contraction uncouplers", American Journal of Physiology – Heart and Circulatory Physiology. 2026.
• Zhen Hua, Konstantinos Patlatzoglou, Vineesh Kappadan*, et al. "AI-enabled motion artifact correction to replace Emission- and Excitation-Ratiometry in Cardiac Optical Mapping: A Proof-of-Concept Study", Cardiovascular Research. 2026.
• Vineesh Kappadan, Anies Sohi, Ulrich Parlitz, et al. "Optical mapping of contracting hearts", Journal of Physiology. 2023.
• Vineesh Kappadan, Saba Telele, Ilija Uzelac, et al. "High Resolution Optical Measurement of Cardiac Restitution, Contraction and Fibrillation Dynamics in Beating vs. Blebbistatin Uncoupled Isolated Rabbit Hearts", Frontiers in Physiology. 2020.