Dr Christopher R Jones

Undergraduate Teaching

• CHE100 Essential Skills for Chemists (tutorials)
• CHE102B Fundamentals of Organic Chemistry (MO)
• CHE202A Structure and Reactivity in Organic Chemistry
• CHE210 Essential Skills for Chemists II (tutorials)
• CHE211 Practical Chemistry (MO)
• CHE600/1 Chemistry Project
• CHE700 Chemical Research Project
• CHE410 Advanced Topics in Chemistry (MO)

Research

Research Interests:

We are a synthetic organic chemistry group, interested in developing new methods that have the potential to impact upon contemporary socioeconomic issues such as new drug discovery and the need to find more sustainable chemical feedstocks.

As such, we aim to harness the high levels of reactivity of arynes, carbenes and radicals (“reactive intermediates”), as they afford unique and powerful opportunities to control challenging new chemical and biological processes.

In our group we are particularly focused on exploiting aryne reactivity for the development of new synthetic strategies, including direct C_sp3-C_sp2 bond formation and aliphatic C-H bond functionalisation, that will enable cheap and abundant hydrocarbon sources to be utilised and therefore reducing our reliance upon more limited and heavily functionalised starting materials.

• Find out more on the Jones Chemistry website

Research department

• Chemistry

Publications

• Browse a list of publications by Dr Christopher Jones
• View Dr Jones' Google Scholar profile

• Li Q, Xu Y, Pedersen A et al. (publicationYear). Investigating the Role of Fe‐Pyrrolic N4 Configuration in the Oxygen Reduction Reaction via Covalently Bound Porphyrin Functionalized Carbon Nanotubes. nameOfConference

  
  

  DOI: 10.1002/adfm.202311086

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/93732
• Xu Y, Xie R, Li Q et al. (2023). Pyridine Functionalized Carbon Nanotubes: Unveiling the Role of External Pyridinic Nitrogen Sites for Oxygen Reduction Reaction. nameOfConference

  
  

  DOI: 10.1002/smll.202302795

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91208
• Idiris FIM, Jones CR (2023). Rarely used strained molecules step up for organic synthesis. nameOfConference

  
  

  DOI: 10.1038/d41586-023-01935-9

  
  

  QMRO: qmroHref
• Sun W, Uttendorfer M, Idiris FIM et al. (2023). Selective access to dihydrophenanthridines and phenanthridinones via cyclisation of aryl amines onto N -tethered arynes. nameOfConference

  
  

  DOI: 10.1039/d3cc03027j

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/91301
• Cao Y, Xu Y, Li Q et al. (2022). Corrosion Inhibition and Disinfection of Heating and Cooling Water Systems Using In Situ Generated Hydrogen Peroxide. nameOfConference

  
  

  DOI: 10.1039/d2nj03806d

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/80695
• Yang Y, Jones CR (2022). The Aryne Ene Reaction. nameOfConference

  
  

  DOI: 10.1055/a-1827-2987

  
  

  QMRO: qmroHref
• Fang L, Crespo-Otero R, Jones CR et al. (2021). Protect to detect: A Golgi apparatus targeted probe to image mobile zinc through the use of a lipophilic cell-labile protecting group strategy. nameOfConference

  
  

  DOI: 10.1016/j.snb.2021.129850

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/73603
• Neal EA, Werling AYR, Jones CR (2021). A simple Hückel model-driven strategy to overcome electronic barriers to retro-Brook silylation relevant to aryne and bisaryne precursor synthesis.. nameOfConference

  
  

  DOI: 10.1039/d0cc08283j

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/70258
• Fang L, Trigiante G, Crespo-Otero R et al. (2019). An alternative modular 'click-SNAr-click' approach to develop subcellular localised fluorescent probes to image mobile Zn2+ .. nameOfConference

  
  

  DOI: 10.1039/c9ob01855g

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/60986
• Fang L, Trigiante G, Crespo-Otero R et al. (2019). Endoplasmic reticulum targeting fluorescent probes to image mobile Zn2+. nameOfConference

  
  

  DOI: 10.1039/c9sc04300d

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/60990
• Yang Y, Xu Y, Jones C (2019). A Ring Expansion Route to Benzofused N-Heterocycles via Aryne Insertion into 1,3-Diaza-heterocycles. nameOfConference

  
  

  DOI: 10.1002/ejoc.201900570

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/57784
• Clement P, Trinchera P, Cervantes-Salguero K et al. (2019). One‐step chemical strategy for the formation of carbon nanotube junctions in aqueous solution: The Reaction of DNA‐WrappedCarbon Nanotubes with Diazonium Salts. nameOfConference

  
  

  DOI: 10.1002/cplu.201900151

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/57723
• JONES CR, TRINCHERA P, SUN W et al. (2018). Aryne-Mediated Arylation of Hantzsch Esters: Access to Highly Substituted Aryl-dihydropyridines, Aryl-tetrahydropyridines and Spiro[benzocyclobutene-1,1′-(3′,4′-dihydropyridines)]. nameOfConference

  
  

  DOI: 10.1055/s-0037-1611065

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/49943
• JONES CR, IDIRIS F, Majesté C et al. (2018). Intramolecular hydride transfer onto arynes: redox-neutral and transition metal-free C(sp3)-H functionalization of amines. nameOfConference

  
  

  DOI: 10.1039/C8SC00181B

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/33651
• JONES CR, Idiris FIM (publicationYear). Recent advances in fluoride-free aryne generation from arene precursors. nameOfConference

  
  

  DOI: 10.1039/c7ob01947e

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/28553
• JONES CR, Trinchera P, Sun W et al. (2017). Intermolecular Aryne Ene Reaction of Hantzsch Esters: Stable Co-valent Ene Adducts from a 1,4-Dihydropyridine Reaction. nameOfConference

  
  

  DOI: 10.1021/acs.orglett.7b02272

  
  

  QMRO: https://qmro.qmul.ac.uk/xmlui/handle/123456789/25450
• Ferguson MD, Donohoe TJ, Jones CR (publicationYear). Lithium 4,4′‐Di‐tert‐butylbiphenylide. nameOfConference

  
  

  DOI: 10.1002/047084289x.rl088.pub2

  
  

  QMRO: qmroHref
• Donohoe TJ, Jones CR, Kornahrens AF et al. (2014). ChemInform Abstract: Total Synthesis of the Antitumor Antibiotic (.+‐.)‐Streptonigrin: First‐ and Second‐Generation Routes for de Novo Pyridine Formation Using Ring‐Closing Metathesis.. nameOfConference

  
  

  DOI: 10.1002/chin.201421241

  
  

  QMRO: qmroHref
• Donohoe TJ, Jones CR, Winter C (2014). 8.22 Partial and Complete Reduction of Pyrroles, Furans, Thiophenes, and their Benzo Analogs, Heterocycles Containing More Than One Heteroatom. nameOfConference

  
  

  DOI: 10.1016/b978-0-08-097742-3.00824-7

  
  

  QMRO: qmroHref
• Donohoe TJ, Jones CR, Kornahrens AF et al. (2013). Total synthesis of the antitumor antibiotic (±)-streptonigrin: first- and second-generation routes for de novo pyridine formation using ring-closing metathesis.. nameOfConference

  
  

  DOI: 10.1021/jo402388f

  
  

  QMRO: qmroHref
• Donohoe TJ, O’Riordan TJC, Peifer M et al. (2012). Asymmetric Synthesis of the Fully Elaborated Pyrrolidinone Core of Oxazolomycin A. nameOfConference

  
  

  DOI: 10.1021/ol302541j

  
  

  QMRO: qmroHref
• Jones CR, Baruah PK, Thompson AL et al. (2012). Can a C-H•••O interaction be a determinant of conformation?. nameOfConference

  
  

  DOI: 10.1021/ja301318a

  
  

  QMRO: qmroHref
• Neier R, Journot G, R. Jones C et al. (2012). The Hydrogenation of Heterocyclic Calix[4]arenes, a Transformation Leading to Novel Macrocyclic Ligands. nameOfConference

  
  

  DOI: 10.3987/rev-11-sr(p)8

  
  

  QMRO: qmroHref
• Donohoe TJ, Jones CR, Barbosa LCA (2011). Total Synthesis of (±)-Streptonigrin: De Novo Construction of a Pentasubstituted Pyridine using Ring-Closing Metathesis. nameOfConference

  
  

  DOI: 10.1021/ja207835w

  
  

  QMRO: qmroHref
• Jones CR, Dan Panto G, Morrison AJ et al. (2009). Plagiarizing proteins: enhancing efficiency in asymmetric hydrogenbonding catalysis through positive cooperativity. nameOfConference

  
  

  DOI: 10.1002/anie.200903063

  
  

  QMRO: qmroHref
• Jones CR, Pantoş GD, Morrison AJ et al. (2009). Plagiarizing Proteins: Enhancing Efficiency in Asymmetric Hydrogen‐Bonding Catalysis through Positive Cooperativity. nameOfConference

  
  

  DOI: 10.1002/ange.200903063

  
  

  QMRO: qmroHref
• Jones CR, Qureshi MKN, Truscott FR et al. (2008). A nonpeptidic reverse turn that promotes parallel sheet structure stabilized by C-H⋯O hydrogen bonds in a cyclopropane γ-peptide. nameOfConference

  
  

  DOI: 10.1002/anie.200802648

  
  

  QMRO: qmroHref
• Jones CR, Qureshi MKN, Truscott FR et al. (2008). A Nonpeptidic Reverse Turn that Promotes Parallel Sheet Structure Stabilized by CH⋅⋅⋅O Hydrogen Bonds in a Cyclopropane γ‐Peptide. nameOfConference

  
  

  DOI: 10.1002/ange.200802648

  
  

  QMRO: qmroHref

Supervision

Current PhD opportunities

• Aryne-mediated metal-free C(sp3)-H bond functionalisation
• Aryne-mediated synthesis of biologically active heterocycles
• Diversity Oriented Synthesis via the Harnessing of Multiple Reactive Intermediates

PhD supervision

• Qi Li
• Haseeb Ur-Rehman Shah
• Mi Zhang
• Peter Lock
• Khushal Siddiq
• Zainab Shafique
• Eleanor Mathias (50:50 with Stellios)
• Kaicheng Zhang (50:50 with Stellios)
• Yibing Chen (50:50 with Stellios)