PHURI Seminar Series

When: , -
Where: Basement, Empire House 67-75 New Road - Hybrid

Speaker: Paul O'Reilly - Icahn School of Medicine at Mount Sinai

While genetic architecture has been investigated extensively at the trait-level, little is known about how genetic architecture varies among individuals across the trait continuum. Here 
we reveal striking departures from polygenicity in the distribution tails of a range of human  traits (e.g. in individuals with high LDL, low/high sitting height, early age of menopause) and implicate stabilising selection as a chief cause.