26 October 2009
Venue: Willoughby Lecture Theatre, Charterhouse Square
'Understanding leukaemia: from gene to genome and back again'
Bryan Young, Professor of Cancer Genomics
Leukaemia is one of the most studied of human cancers. Cytogenetics has uncovered a host of chromosomal abnormalities which have been shown to have a role in prognosis, therapy and gene discovery. Cytogenetic analysis of Barts's patients led directly to the discovery of the MLL and AF10 genes, which are frequently fused by chromosomal translocation. The inhibition of such a gene fusion product, the BCR-ABL kinase in patients with the t(9;22) translocation, is an outstanding example of how these events can be exploited for therapeutic benefit. The current genomic revolution in both arrays and sequencing promises to transform our understanding of the cancer cell by taking our analysis to the ultimate level of the single nucleotide. Bryan Young will discuss his research in the field of leukaemia and explore the challenges and opportunities offered by these exciting new technologies.
Bryan Young studied Natural Philosophy at the University of Glasgow and Gained his PhD for research at Glasgow Royal Infirmary. He was recruited to the Beatson Institute by the director John Paul to begin early gene/genome research. He was recruited to the ICRF in London to head the Medical Oncology Unit laboratory at St Bartholomew’s Hospital. He subsequently relocated the laboratory to Charterhouse Square and now heads the Cancer Genomics group.
Medicine and Dentistry