In a review published in Blood Cancer Journal, members of the Deniz Lab bring together current knowledge on the roles of transposable elements in normal and malignant haematopoiesis.
Fig. 1: Transposable elements in the human genome.
In a review published in Blood Cancer Journal, members of the Deniz Lab bring together current knowledge on the roles of transposable elements in normal and malignant haematopoiesis. The article, titled Transposable elements as genome regulators in normal and malignant haematopoiesis, explores how transposable elements (TEs) serve as powerful drivers of genome innovation and regulators of gene expression. The article highlights recent advances in experimental and computational tools that have deepened our understanding of TE functions in normal blood development and their disruptive roles in haematological cancers.
As research in this area progresses, it is becoming clear that TEs are not merely passive passengers in our genome, but active participants that can influence health and disease in subtle and significant ways. From acting as enhancers and alternative promoters to generating chimeric transcripts and novel antigens, TEs have emerged as both regulators of normal haematopoietic processes and potential drivers of malignancy. These insights not only advance our basic understanding of genome biology but also open up exciting new avenues for therapeutic strategies targeting TE activity in blood cancers.
To read the full article please follow this link: Transposable elements as genome regulators in normal and malignant haematopoiesis | Blood Cancer Journal