Shcherbo lab
Epigenomics of cell-free nucleic acids
Using advanced lab techniques and cutting-edge computational tools, we decode multiple layers of information from cell-free DNA and RNA fragments found in blood. Together with clinical collaborators, we aim to improve diagnostics for various conditions, including pregnancy complications and cancer. Our ambition is to translate research into clinical practice and improve patient lives.
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Selected publications
Wang H, Mennea PD, Chan YKE, Cheng Z, Neofytou MC, Surani AA, Vijayaraghavan A, Ditter EJ, Bowers R, Eldridge MD, Shcherbo DS, Smith CG, Markowetz F, Cooper WN, Kaplan T, Rosenfeld N, Zhao H. A standardized framework for robust fragmentomic feature extraction from cell-free DNA sequencing data. Genome Biol. 2025;26(1):141
Koval AP, Khromova AS, Blagodatskikh KA, Zhitnyuk YV, Shtykova YA, Alferov AA, Kushlinskii NE, Shcherbo DS* Application of PCR-based approaches for evaluation of cell-free DNA fragmentation in colorectal cancer. Front Mol Biosci. 2023;10:1101179.
Zhitnyuk YV, Koval AP, Alferov AA, Shtykova YA, Mamedov IZ, Kushlinskii NE, Chudakov DM, Shcherbo DS* Deep cfDNA fragment end profiling enables cancer detection. Mol Cancer. 2022;21(1):1-5.
Koval AP, Blagodatskikh KA, Kushlinskii NE, Shcherbo DS*. The Detection of Cancer Epigenetic Traces in Cell-Free DNA. Front Oncol. 2021;11:1492.
Shemiakina II, Ermakova GV, Cranfill PJ, …, Davidson MW, Chudakov DM, Shcherbo D. A monomeric red fluorescent protein with low cytotoxicity. Nat Commun. 2012;3(1):1204.
Shcherbo D, Shemiakina II, Ryabova AV, et al. Near-infrared fluorescent proteins. Nat Methods. 2010;7(10):827-829.