Current Studies
The PCTU is actively engaged in a wide variety of trials (including CTIMPS), systematic reviews and observational studies at different stages of their development. The Unit supports high quality research across many different clinical areas with particular strengths in primary care, psychiatry, women’s health, critical care, colorectal surgery and perioperative medicine.
Click on the study name below for details of our current studies.
ASSURED
Study: ASsuRED: Improving outcomes in patients who self-harm – Adapting and evaluating a brief pSychological inteRvention in Emergency Departments
Chief Investigator: Professor Rose McCabe
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0617-20004)
Sponsor: City, University of London
PCTU Ref: P264
EMPOWER
Study: Enabling and Motivating People (with a Personality Disorder) in Occupation, Wellbeing, Education and Responsibility
Chief Investigator: Dr Janet Feigenbaum, North East London NHS Foundation Trust
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-1212-20011)
Sponsor: North East London NHS Foundation Trust
PCTU Ref: P257
Study: Living well with Inflammatory Bowel Disease: improving symptoms of chronic abdominal pain, fatigue and incontinence by guided self-management
Chief Investigator: Professor Christine Norton
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0216-20001)
Sponsor: London North West University Healthcare NHS Trust
PCTU Ref: P211
ENRICH
Study: Enhanced discharge from inpatient to community mental health care (ENRICH): a programme of applied research to manualise, pilot and trial a Peer Worker intervention
Chief Investigator: Professor Steve Gillard, St George's, University of London
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-1212-20019)
Sponsor: South West London and St George’s Healthcare NHS Trust
PCTU Ref: P154
IMP2ART
Study: Implementing supported asthma self-management in routine clinical care: designing, refining, piloting and evaluating clinical and cost-effectiveness of a whole systems implementation strategy
Chief Investigator: Dr Hilary Pinnock, University of Edinburgh and Professor Stephanie Taylor, Queen Mary University of London
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-1016-20008)
Sponsor: NHS Kent and Medway CCG
PCTU Ref: P243
NEON
Study: Personal experience as a recovery resource in severe mental illness: Narrative Experiences ONline
Chief Investigator: Professor Mike Slade, University of Nottingham
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0615-20016)
Sponsor: Nottinghamshire Healthcare NHS Foundation Trust
PCTU Ref: P227
OSIRIS
Study: Optimising Shared Decision Making for High Risk Major Surgery
Chief Investigator: Professor Rupert Pearse, Queen Mary University of London
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0218-20001)
Sponsor: Barts Health NHS Trust
PCTU Ref: P249
REACH
Study: The REACH Pregnancy Programme (Research for Equitable Antenatal Care and Health)
Chief Investigator: Professor Angela Harden, University of East London
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-1211-20015)
Sponsor: University of East London
PCTU Ref: P123
STOP
Study: Optimising pharmacist-based treatment for smoking cessation
Chief Investigator: Professor Robert Walton, Queen Mary University of London
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0609-10181)
Sponsor: Barts NHS Trust
PCTU Ref: P027
SURECAN
Study: SUrvivors Rehabilitation Evaluation after CANcer
Chief Investigator: Professor Stephanie Taylor, Queen Mary University of London
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0616-20002)
Sponsor: Barts NHS Trust
PCTU Ref: P228
TACK
Study: Tackling chronic depression - Adapting and testing a technology supported, patient-centred and solution focused intervention (DIALOG+) in primary care
Chief Investigator: Dr Vicky Bird, Queen Mary University of London
Funder/Funding Stream: NIHR Programme Grants for Applied Research (RP-PG-0615-20010)
Sponsor: East London NHS Foundation Trust
PCTU Ref: P207
CHARIOT-MS
Study: Cladribine to halt deterioration in people with advanced Multiple Sclerosis
Chief Investigator: Professor Klaus Schmierer
Funder/Funding Stream: NIHR Efficacy and Mechanism Evaluation (EME) (17/145/09)
Sponsor: Queen Mary university of London
PCTU Ref: P258
BLIPA
Study: Oral bacterial lysate to prevent persistent wheeze in infants after severe bronchiolitis; a randomised placebo controlled trial (BLIPA; Bacterial Lysate in Preventing Asthma)
Chief Investigator: Professor Jonathan Grigg
Funder/Funding Stream: NIHR Efficacy and Mechanism Evaluation (EME) (NIHR128778)
Sponsor: Queen Mary University of London
PCTU Ref: P310
ATTACK MS
Study: Natalizumab for the acute treatment of people at high risk of relapsing multiple sclerosis
Chief Investigator: Professor Klaus Schmierer
Funder/Funding Stream: Biogen Idec Ltd
Sponsor: Queen Mary university of London
PCTU Ref: P327
CHILL
Study: Investigating the impact of London's Ultra Low Emission Zone on children's respiratory health. A cohort study to evaluate Ultra Low Emission Zone
Chief Investigator: Professor Chris Griffiths, Queen Mary University of London
Funder/Funding Stream: NIHR Public Health Research (16/139/01)
Sponsor: Barts NHS Trust
PCTU Ref: P242
Study: A cluster trial of the benefits of a place and household-level subsidy for fresh fruit and vegetables on diet, health and the wider environment
Chief Investigator: Dr Clare Relton, Queen Mary University of London
Funder/Funding Stream: NIHR Public Health Research (NIHR129937)
Sponsor: Queen Mary university of London
PCTU Ref: P318
FReDA
Study: The FReDA Project: Family Recovery after Domestic Abuse
Chief Investigator: Dr Emma Howarth
Funder/Funding Stream: Public Health Research (NIHR127793)
Sponsor: University of East London
PCTU Ref: P341
ERA
Study: Effectiveness Of Group Arts Therapy Compared To Group Counselling For Diagnostically Heterogeneous Psychiatric Community Patients: Randomised Controlled Trial In Mental Health Services
Chief Investigators: Dr Catherine Carr, Queen Mary University of London and Professor Stefan Priebe, Queen Mary University of London
Funder/Funding Stream: NIHR Health Technology Assessment (17/29/01)
Sponsor: East London NHS Foundation Trust
PCTU Ref:P262
FLO-ELA
Study: FLuid Optimisation in Emergency LAparotomy. Open, multi-centre, randomised controlled trial of cardiac output -guided haemodynamic therapy compared to usual care in patients undergoing emergency bowel surgery
Chief Investigator: Dr Mark Edwards, University Hospital Southampton NHS Foundation Trust
Funder/Funding Stream: NIHR Health Technology Assessment Clinical Trials & Evaluation (15/80/54)
Spondor: University Hospital Southampton NHS Foundation Trust
PCTU Ref: P217
IPPIC
Study: Accuracy of clinical characteristics, biochemical and ultrasound markers in the prediction of preeclampsia: an Individual Patient Data (IPD) Meta-analysis
Chief Investigator: Professor Shakila Thangaratinam, Queen Mary University of London
Funder/Funding Stream: NIHR Health Technology Assessment (14/158/02)
Sponsor: Barts NHS Trust
PCTU Ref: P177
TANDEM
Study: A tailored, cognitive behavioural approach intervention for mild to moderate anxiety and/or depression in people with chronic obstructive pulmonary disease (COPD): A randomised controlled trial (TANDEM Tailored intervention for ANxiety and DEpression Management in COPD)
Chief Investigator: Professor Stephanie Taylor, Queen Mary University of London
Funder/Funding Stream: NIHR Health Technology Assessment (13/146/02)
Sponsor: Barts NHS Trust
PCTU Ref: P159
Eye-2-i
Study: The Early Youth Engagement in first episode psychosis (EYE-2) study: pragmatic cluster randomised controlled trial of implementation, effectiveness & cost effectiveness of a team-based motivational engagement intervention to improve engagement
Chief Investigator: Dr Kathy Greenwood, University of Sussex
Funder/Funding Stream: NIHR Health Services & Delivery Research Programme (16/31/87)
Sponsor: Sussex Partnership NHS Foundation Trust
PCTU Ref: P252
PROMISe
Study: Patient Reported Outcome MeasureS using electronic informed consent and data capture – developing methods and infrastructure
Chief Investigators: Professor Sandra Eldridge, Dr Richard Hooper, Professor Charles Knowles; Queen Mary University of London
Funder/Funding Stream: NIHR CTU Support Funding (NIHR129741)
Sponsor: Barts NHS Trust
PCTU Ref: P265
OPTIMISE II
Study: OPTimisation of cardIovascular Management to Improve Surgical outcomE II
Chief Investigator: Professor Rupert Pearse, Queen Mary University of London
Funder/Funding Stream: Edwards Lifesciences
Sponsor: Barts Health NHS Trust
PCTU Ref: P221
PROMETHEUS
Study: Routinely embedding recruitment and retention interventions within randomised controlled trials
Chief Investigator: Professor David Torgerson, University of York
Funder/Funding Stream: MRC Methodology Research Panel (MR/R013748/1)
Sponsor: University of York
PCTU Ref: P268
SENSE-MS
Study: Validity of Floodlight remote patient monitoring -substudy to MS-Chariot
Chief Investigator: Professor Klaus Schmierer
Funder/Funding Stream: Roche
Sponsor: Queen Mary university of London
PCTU Ref: P326
SUBSoNIC
Study: Randomised Double-Blind Efficacy and Mechanism Study Of Sacral Neuromodulation In Adults With Faecal Incontinence
Chief Investigator: Professor Charles Knowles, Queen Mary University of London
Funder/Funding Stream: NIHR Efficacy and Mechanism Evaluation (EME) (14/144/08) and Medtronic Inc
Sponsor: Barts NHS Trust
PCTU Ref: P178
VidiKIDS
Study: Trial of vitamin D supplementation to prevent acquisition of latent tuberculosis infection in schoolchildren
Chief Investigator: Professor Adrian Martineau, Queen Mary University of London
Funder/Funding Stream: Medical Research Council (MRC) (MR/M026639/1)
Sponsor: Barts NHS Trust
PCTU Ref: P186
VidiKIDS NCD - Substudy
Study: Trial of vitamin D supplementation to prevent acquisition of latent tuberculosis infection in schoolchildren
Chief Investigator: Professor Adrian Martineau, Queen Mary University of London
Funder/Funding Stream: Medical Research Council (MRC)
Sponsor: Barts NHS Trust
PCTU Ref: P274
Study: The INCLUDED study focuses on improving inclusion and diversity in UK clinical trials through understanding how ethnicity data are collected, used, and reported in order to make recommendations to improve engagement with trials and impact of trials for under-served groups.
Lead: Professor Sandra Eldridge
Funder/Funding Stream: NIHR CTU Support Funding
Sponsor: Queen Mary University of London
PCTU Ref: P364
