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The William Harvey Research Institute - Faculty of Medicine and Dentistry

Publications including course students

Ward EJ, Bert S, Fanti S, et al. Placental Inflammation Leads to Abnormal Embryonic Heart Development. Circulation, 2023.
Bert S, Nadkarni S, Perretti M. Neutrophil-T cell crosstalk and the control of the host inflammatory response. Immunological Reviews, 2023.
Patel, N., Yaqoob, M.M. & Aksentijevic, D. Cardiac metabolic remodelling in chronic kidney disease. Nat Rev Nephrol 18, 524–537 (2022).
McClements, L., Richards, C., Patel, N. et al. Impact of reduced uterine perfusion pressure model of preeclampsia on metabolism of placenta, maternal and fetal hearts. Sci Rep 12, 1111 (2022).
Sheikh MH, Errede M, d'Amati A, Khan NQ, Fanti S, Loiola RA, McArthur S, Purvis GSD, O'Riordan CE, Ferorelli D, Dell'Erba A, Kieswich J, Reutelingsperger C, Maiorano E, Yaqoob M, Thiemermann C, Baragetti A, Catapano AL, Norata GD, Marelli-Berg F, Virgintino D, Solito E. Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues. FASEB J. 2022 Jan;36(1):e22107. doi: 10.1096/fj.202101297R. PMID: 34939700.
Vyas V, Blythe H, Wood EG, Sandhar B, Sarker SJ, Balmforth D, Ambekar SG, Yap J, Edmondson SJ, Di Salvo C, Wong K, Roberts N, Uppal R, Adams B, Shipolini A, Oo AY, Lawrence D, Kolvekar S, Lall KS, Finlay MC, Longhi MP. Obesity and diabetes are major risk factors for epicardial adipose tissue inflammation. JCI Insight. 2021 Aug 23;6(16):e145495. doi: 10.1172/jci.insight.145495. PMID: 34283808; PMCID: PMC8409986.
Bert S, Ward EJ, Nadkarni S. Neutrophils in pregnancy: New insights into innate and adaptive immune regulation. Immunology, July 2021.
Mohammad S, Al Zoubi S, Collotta D, Krieg N, Wissuwa B, Ferreira Alves G, Purvis GSD, Norata GD, Baragetti A, Catapano AL, Solito E, Zechendorf E, Schürholz T, Correa-Vargas W, Brandenburg K, Coldewey SM, Collino M, Yaqoob MM, Martin L, Thiemermann C. A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice. Front Immunol. 2021 Jul 19;12:701275. doi: 10.3389/fimmu.2021.701275. PMID: 34349763; PMCID: PMC8328475.
Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP, Filomena F, Nuredini G, Ibrahim AS, Khambata RS, Gupta AK, Moon JC, Kapil V, Ahluwalia A. Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide. Br J Pharmacol. 2021 Jul 26. doi: 10.1111/bph.15636. Online ahead of print.
Werth K, Hub E, Gutjahr JC, Bosjnak B, Zheng X, Bubke A, Russo S, Rot A, Förster R. Expression of ACKR4 demarcates the "peri-marginal sinus," a specialized vascular compartment of the splenic red pulp. Cell Rep. 2021 Jul 13;36(2):109346. doi: 10.1016/j.celrep.2021.109346. PMID: 34260918.
Review: Bert, S, Ward, EJ, Nadkarni, S. Neutrophils in pregnancy: New insights into innate and adaptive immune regulation. Immunology. 2021.
Olczak, KJ*, Taylor-Bateman, V*, Nicholls, HL*, Traylor, M, Cabrera, CP and Munroe, PB. Hypertension genetics past, present and future applications. Journal of Internal Medicine 2021 *co-first author.
Olczak KJ, Taylor-Bateman V, Nicholls HL, Traylor M, Cabrera CP, Munroe PB. Hypertension genetics past, present and future applications. J Intern Med. 2021 Jun 24. doi: 10.1111/joim.13352. Epub ahead of print. PMID: 34166551.Hearnden R, Sandhar B, Vyas V, Longhi MP. Isolation of stromal vascular fraction cell suspensions from mouse and human adipose tissues for downstream applications. STAR Protoc. 2021 Mar 30;2(2):100422. doi: 10.1016/j.xpro.2021.100422. PMID: 33870227; PMCID: PMC8044717.
Mohammad S, Thiemermann C. Role of Metabolic Endotoxemia in Systemic Inflammation and Potential Interventions. Front Immunol. 2021;11:594150. Published 2021 Jan 11. doi:10.3389/fimmu.2020.594150
O'Riordan CE, Purvis GSD, Collotta D, Krieg N, Wissuwa B, Sheikh MH, Ferreira Alves G, Mohammad S, Callender LA, Coldewey SM, Collino M, Greaves DR, Thiemermann C. X-Linked Immunodeficient Mice With No Functional Bruton's Tyrosine Kinase Are Protected From Sepsis-Induced Multiple Organ Failure. Front Immunol. 2020 Oct 7;11:581758. doi: 10.3389/fimmu.2020.581758. PMID: 33162995; PMCID: PMC7580254.
Cheung, K.C.P., Fanti, S., Mauro, C. et al. Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming. Nat Commun 11, 3595, July 2020, https://doi.org/10.1038/s41467-020-17329-8
Elisabeth Zechendorf, Caroline E. O’Riordan, Lara Stiehler, Natalie Wischmeyer, Fausto Chiazza, Debora Collotta, Bernd Denecke, Sabrina Ernst, Gerhard Müller-Newen, Sina M. Coldewey, Bianka Wissuwa, Massimo Collino, Tim-Philipp Simon, Tobias Schuerholz, Christian Stoppe, Gernot Marx, Christoph Thiemermann, Lukas Martin. Ribonuclease 1 attenuates septic cardiomyopathy and cardiac apoptosis – a reverse-translational study. Journal of Clinical Investigation Insight. JCI Insight. 2020;5(8):e131571. https://doi.org/10.1172/jci.insight.131571.
James H Cartwright, Qadeer Aziz, Stephen C Harmer, Sudhin Thayyil, Andrew Tinker, Patricia B Munroe, Genetic variants in TRPM7 associated with unexplained stillbirth modify ion channel function, Human Molecular Genetics, Volume 29, Issue 11, 1 June 2020, Pages 1797–1807, https://doi.org/10.1093/hmg/ddz198.
Purvis GSD, Collino M, Aranda-Tavio H, Chiazza F, O'Riordan CE, Zeboudj L, Mohammad S, Collotta D, Verta R, Guisot NES, Bunyard P, Yaqoob MM, Greaves DR, Thiemermann C. Inhibition of Bruton's TK regulates macrophage NF-κB and NLRP3 inflammasome activation in metabolic inflammation. Br J Pharmacol. 2020 Oct;177(19):4416-4432. doi: 10.1111/bph.15182. Epub 2020 Aug 26. PMID: 32608058; PMCID: PMC7484557.
Nicholls HL, John CR, Watson DS, Munroe PB, Barnes MR and Cabrera CP. Reaching the End-Game for GWAS: Machine Learning Approaches for the Prioritisation of Complex Disease Loci. Frontiers Genetics 2020.
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS, Hobbs AJ. C-type natriuretic peptide co-ordinates cardiac structure and function. Eur Heart J. 2020 Mar 1;41(9):1006-1020. doi: 10.1093/eurheartj/ehz093.
Zub E, Canet G, Garbelli R, Blaquiere M, Rossini L, Pastori C, Sheikh M, Reutelingsperger C, Klement W, de Bock F, Audinat E, Givalois L, Solito E, Marchi N. The GR-ANXA1 pathway is a pathological player and a candidate target in epilepsy. FASEB J. 2019 Dec;33(12):13998-14009. doi: 10.1096/fj.201901596R. Epub 2019 Oct 16. PMID: 31618599.
Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J, Bedi KC Jr, Margulies KB, Sanz-Moreno V, Hobbs A, Hodivala-Dilke K. Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. J Pathol. 2019 Dec;249(4):523-535. doi: 10.1002/path.5340. Epub 2019 Oct 30.
Colamatteo A, Maggioli E, Azevedo Loiola R, Hamid Sheikh M, Calì G, Bruzzese D, Maniscalco GT, Centonze D, Buttari F, Lanzillo R, Perna F, Zuccarelli B, Mottola M, Cassano S, Galgani M, Solito E, De Rosa V. Reduced Annexin A1 Expression Associates with Disease Severity and Inflammation in Multiple Sclerosis Patients. J Immunol. 2019 Oct 1;203(7):1753-1765. doi: 10.4049/jimmunol.1801683. Epub 2019 Aug 28. PMID: 31462505.
Claudia P Cabrera, Fu Liang Ng, Hannah L Nicholls, Ajay Gupta, Michael R Barnes, Patricia B Munroe, Mark J Caulfield, Over 1000 genetic loci influencing blood pressure with multiple systems and tissues implicated, Human Molecular Genetics, Volume 28, Issue R2, 15 October 2019, Pages R151–R161, https://doi.org/10.1093/hmg/ddz197
O'Riordan CE, Purvis GSD, Collotta D, Chiazza F, Wissuwa B, Al Zoubi S, Stiehler L, Martin L, Coldewey SM, Collino M, Thiemermann C. Bruton's Tyrosine Kinase Inhibition Attenuates the Cardiac Dysfunction Caused by Cecal Ligation and Puncture in Mice. Front Immunol. 2019 Sep 6;10:2129. doi: 10.3389/fimmu.2019.02129. PMID: 31552054; PMCID: PMC6743418.
Podaru MN, Fields L, Kainuma S, Ichihara Y, Hussain M, Ito T, Kobayashi K, Mathur A, D'Acquisto F, Lewis-McDougall F, Suzuki K. Reparative macrophage transplantation for myocardial repair: a refinement of bone marrow mononuclear cell-based therapy. Basic Res Cardiol. 2019 Aug 1;114(5):34. doi: 10.1007/s00395-019-0742-1. PMID: 31372765; PMCID: PMC6675756.
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS, Hobbs AJ. C-type natriuretic peptide co-ordinates cardiac structure and function. Eur Heart J. 2020 Mar 1;41(9):1006-1020. doi: 10.1093/eurheartj/ehz093. PMID: 30903134; PMCID: PMC7068173.
Purvis GSD, Collino M, Loiola RA, Baragetti A, Chiazza F, Brovelli M, Sheikh MH, Collotta D, Cento A, Mastrocola R, Aragno M, Cutrin JC, Reutelingsperger C, Grigore L, Catapano AL, Yaqoob MM, Norata GD, Solito E and Thiemermann C (2019) Identification of AnnexinA1 as an Endogenous Regulator of RhoA, and Its Role in the Pathophysiology and Experimental Therapy of Type-2 Diabetes. Front. Immunol. 10:571. doi: 10.3389/fimmu.2019.00571Cabrera CP, Ng FL, Nicholls HL, Gupta A, Barnes MR, Munroe PB, et al. Over 1,000 genetic loci influencing blood pressure with multiple systems and tissues implicated. Human Molecular Genetics 2019.h
Macdougall CE, Wood EG, Solomou A, Scagliotti V, Taketo MM, Gaston-Massuet C, Marelli-Berg FM, Longhi MP (2019). Constitutive activation of β-Catenin in conventional dendritic cells increases the insulin reserve to ameliorate the development of type 2 diabetes in mice. Diabetes. Jul 2018; 68(7):1473-1484.
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA, Hobbs AJ. Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure. Proc Natl Acad Sci USA. 2018 Jul 31;115(31):E7428-E7437. doi: 10.1073/pnas.1800996115. Epub 2018 Jul 16. PMID: 30012589; PMCID: PMC6077693.
MacDougall CE & Longhi MP (2018). Adipose Tissue Dendritic Cells in Steady-State. Immunology. Mar 2018;156(5):228-234.
Cassidy FC, Charalambous M. Genomic imprinting, growth and maternal-fetal interactions. J Exp Biol. 2018 Mar 7;221(Pt Suppl 1):jeb164517. doi: 10.1242/jeb.164517. PMID: 29514882.
Macdougall CE, Wood EG, Loschko J, Scagliotti V, Cassidy FC, Robinson ME, Feldhahn N, Castellano L, Voisin MB, Marelli-Berg F, Gaston-Massuet C, Charalambous M, Longhi MP. Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell Subsets. Cell Metab. 2018 Mar 6;27(3):588-601.e4. doi: 10.1016/j.cmet.2018.02.007. PMID: 29514067; PMCID: PMC5846800.
Sheikh M and Solito E. Annexin A1: Uncovering the Many Talents of an Old Protein. Int. J. Mol. Sci. 2018, 19(4), 1045
Ghezzi P, Floridi L, Boraschi D, Cuadrado A, Manda G, Levic S, D'Acquisto F, Hamilton A, Sthersuch T, Selley L. Oxidative Stress and Inflammation Induced by Environmental and Psychological Stressors: A Biomarker Perspective. Antioxidants & Redox Signaling, March 2018.
Postmortem Genetic Testing for Cardiac Ion Channelopathies in Stillbirths

Patricia B. Munroe, PhD, Shea Addison, BSc, Dominic J. Abrams, MD, Neil J. Sebire, FRCPath, MD, James Cartwright, PhD, Ian Donaldson, PhD, Marta M. Cohen, FRCPath, Charles Mein, PhD, Andrew Tinker, PhD, Stephen C. Harmer, PhD, Qadeer Aziz, PhD, Anna Terry, PhD, Monika Struebig, PhD, Helen R. Warren, PhD, Bhumita Vadgama, FRCPath, Darren J. Fowler, FRCPath, Donald Peebles, FRCOG, Andrew M. Taylor, FRCR, MD, Peter J. Lally, DPhy, and Sudhin Thayyil, MD, FRCP, PhD. Postmortem genetic testing for cardiac ion channelopathies in stillbirths" - Circulation: Genomic and Precision Medicine, 11 Jan 2018, https://doi.org/10.1161/CIRCGEN.117.001817
Nelson C, Goel A, Butterworth A, Kanoni S, Webb T, Marouli E, Zeng L, Ntalla I, Lai F, Hopewell J, Giannakopoulou O, Jiang T, Hamby S, Di Angelantonio E, Assimes T, Bottinger E, Chambers J, Clarke R, Palmer C, Cubbon R, Ellinor P, Ermel R, Evangelou E, Franks P, Grace C, Gu D, Hingorani A, Howson J, Ingelsson E, Kastrati A, Kessler T, Kyriakou T, Lehtimäki T, Lu X, Lu Y, März W, McPherson R, Metspalu A, Pujades-Rodriguez M, Ruusalepp A, Schadt E, Schmidt A, Sweeting M, Zalloua P, AlGhalayini K, Keavney B, Kooner J, Loos R, Patel R, Rutter M, Tomaszewski M, Tzoulaki I, Zeggini E, Erdmann J, Dedoussis G, Björkegren J, EPIC-CVD Consortium, CARDIoGRAMplusC4D, The UK Biobank CardioMetabolic Consortium CHD working group, Schunkert H, Farrall M, Danesh J, Samani N, Watkins H & Deloukas P. Association analyses based on false discovery rate implicate new loci for coronary artery disease. Nat Genet 49, 1385–1391 (2017).
Alexopoulou, A. N., Lees, D. M., Bodrug, N., Lechertier, T., Fernandez, I., D'Amico, G., Dukinfield, M., Batista, S., Tavora, B., Serrels, B., & Hodivala-Dilke, K. (2017). Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice. The Journal of pathology, 242(3), 358–370. https://doi.org/10.1002/path.4911
Accelerated resolution underlies sex differences in the inflammatory response in humans. Krishnaraj S. Rathod, Vikas Kapil, Shanti Velmurugan, Rayomand S. Khambata, Umme Siddique, Saima Khan, Sven Van Eijl, Lorna C Gee, Jaspal Bansal, Kavi Pitrola, Christopher Shaw, Fulvio D’Acquisto, Romain A. Colas, Federica Marelli-Berg, Jesmond Dalli, Amrita Ahluwalia. Journal of Clinical Investigation, 2017 Jan 3;127(1):169-182. 27893465
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension, Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X, Barnes DR, Witkowska K, Staley JR, Tragante V, Tukiainen T, Yaghootkar H, Masca N, Freitag DF, Ferreira T, Giannakopoulou O, Tinker A, Harakalova M, Mihailov E, Liu C, Kraja AT, Nielsen SF, Rasheed A, Samuel M, Zhao W, Bonnycastle LL, Jackson AU, Narisu N, Swift AJ, Southam L, Marten J, Huyghe JR, Stančáková A, Fava C, Ohlsson T, Matchan A, Stirrups KE, Bork-Jensen J, Gjesing AP, Kontto J, Perola M, Shaw-Hawkins S, Havulinna AS, Zhang H, Donnelly LA, Groves CJ, Rayner NW, Neville MJ, Robertson NR, Yiorkas AM, Herzig KH, Kajantie E, Zhang W, Willems SM, Lannfelt L, Malerba G, Soranzo N, Trabetti E, Verweij N, Evangelou E, Moayyeri A, Vergnaud AC, Nelson CP, Poveda A, Varga TV, Caslake M, de Craen AJ, Trompet S, Luan J, Scott RA, Harris SE, Liewald DC, Marioni R, Menni C, Farmaki AE, Hallmans G, Renström F, Huffman JE, Hassinen M, Burgess S, Vasan RS, Felix JF; CHARGE-Heart Failure Consortium, Uria-Nickelsen M, Malarstig A, Reilly DF, Hoek M, Vogt TF, Lin H, Lieb W; EchoGen Consortium, Traylor M, Markus HS; METASTROKE Consortium, Highland HM, Justice AE, Marouli E; GIANT Consortium, Lindström J, Uusitupa M, Komulainen P, Lakka TA, Rauramaa R, Polasek O, Rudan I, Rolandsson O, Franks PW, Dedoussis G, Spector TD; EPIC-InterAct Consortium, Jousilahti P, Männistö S, Deary IJ, Starr JM, Langenberg C, Wareham NJ, Brown MJ, Dominiczak AF, Connell JM, Jukema JW, Sattar N, Ford I, Packard CJ, Esko T, Mägi R, Metspalu A, de Boer RA, van der Meer P, van der Harst P; Lifelines Cohort Study, Gambaro G, Ingelsson E, Lind L, de Bakker PI, Numans ME, Brandslund I, Christensen C, Petersen ER, Korpi-Hyövälti E, Oksa H, Chambers JC, Kooner JS, Blakemore AI, Franks S, Jarvelin MR, Husemoen LL, Linneberg A, Skaaby T, Thuesen B, Karpe F, Tuomilehto J, Doney AS, Morris AD, Palmer CN, Holmen OL, Hveem K, Willer CJ, Tuomi T, Groop L, Käräjämäki A, Palotie A, Ripatti S, Salomaa V, Alam DS, Majumder AA, Di Angelantonio E, Chowdhury R, McCarthy MI, Poulter N, Stanton AV, Sever P, Amouyel P, Arveiler D, Blankenberg S, Ferrières J, Kee F, Kuulasmaa K, Müller-Nurasyid M, Veronesi G, Virtamo J, Deloukas P; Wellcome Trust Case Control Consortium, Elliott P; Understanding Society Scientific Group, Zeggini E, Kathiresan S, Melander O, Kuusisto J, Laakso M, Padmanabhan S, Porteous DJ, Hayward C, Scotland G, Collins FS, Mohlke KL, Hansen T, Pedersen O, Boehnke M, Stringham HM; EPIC-CVD Consortium, Frossard P, Newton-Cheh C; CHARGE+ Exome Chip Blood Pressure Consortium, Tobin MD, Nordestgaard BG; T2D-GENES Consortium; GoT2DGenes Consortium; ExomeBP Consortium; CHD Exome+ Consortium, Caulfield MJ, Mahajan A, Morris AP, Tomaszewski M, Samani NJ, Saleheen D, Asselbergs FW, Lindgren CM, Danesh J, Wain LV, Butterworth AS, Howson JM, Munroe PB. Nat Genet. 2016 Oct;48(10):1151-61. doi: 10.1038/ng.3654.
REPRINT
Mechanisms of T cell organotropism, Fu H, Ward EJ, Marelli-Berg FM. Cell Mol Life Sci. 2016 Aug;73(16):3009-33. doi: 10.1007/s00018-016-2211-4.
REPRINT
Dietary Nitrate Lowers Blood Pressure: Epidemiological, Pre-clinical Experimental and Clinical Trial Evidence. Gee LC, Ahluwalia A. Curr Hypertens Rep. 2016 Feb;18(2):17. doi: 10.1007/s11906-015-0623-4.
Dietary Nitrate Lowers Blood Pressure: Epidemiological, Pre-clinical Experimental and Clinical Trial Evidence. Gee LC, Ahluwalia A. Invited review Current Opinion in Hypertension 2016 Jan;18(2):17