IUBMB Enzyme Nomenclature

EC 4.6.1.22

Accepted name: Bacillus subtilis ribonuclease

Reaction: RNA = a 5'-hydroxy-ribonucleotide + n nucleoside-2',3'-cyclophosphates

Other name(s): Proteus mirabilis RNase; ribonucleate nucleotido-2'-transferase (cyclizing); bacterial RNA lyase; Bacillus subtilis intracellular ribonuclease

Systematic name: [RNA] 5'-hydroxy-ribonucleotide-3'-[RNA fragment]-lyase (cyclicizing; [RNA fragment]-3'- nucleoside -2',3'-cyclophosphate-forming)

Comments: This enzyme catalyses endonucleolytic cleavage to 2',3'-cyclic nucleotides. The cyclic products may be hydrolysed to the corresponding 3'-phosphates by 2',3'-cyclic-nucleotide 2'-phosphodiesterase (EC 3.1.4.16). The enzyme from B. subtilis is inhibited by ATP.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Nishimura, H. and Maruo, B. Intracellular ribonuclease from Bacillus subtilis. Biochim. Biophys. Acta 40 (1960) 355-357. [PMID: 13854124]

2. Yamasaki, M. and Arima, K. Regulation of intracellular ribonuclease of Bacillus subtilis by ATP and ADP. Biochim. Biophys. Acta 139 (1967) 202-204. [PMID: 4962137]

3. Yamasaki, M. and Arima, K. Intracellular ribonuclease of Bacillus subtilis; specific inhibition by ATP and dATP. Biochem. Biophys. Res. Commun. 37 (1969) 430-436. [PMID: 4981632]

4. Center, M.S. and Behal, F.J. Studies on the ribonuclease activity of Proteus mirabilis. Biochim. Biophys. Acta 151 (1968) 698-699. [PMID: 4296400]

[EC 4.6.1.22 created 1978 as EC 3.1.27.2, transferred 2028 to EC 4.6.1.22]


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