Reaction: threo-3-hydroxy-D-aspartate = oxaloacetate + NH3
Other name(s): D-threo-3-hydroxyaspartate dehydratase
Systematic name: threo-3-hydroxy-D-aspartate ammonia-lyase (oxaloacetate-forming)
Comments: A pyridoxal-phosphate protein. The enzyme, purified from the bacterium Delftia sp. HT23, also has activity against L-threo-3-hydroxyaspartate, L-erythro-3-hydroxyaspartate, and D-serine. Different from EC 184.108.40.206, erythro-3-hydroxy-L-aspartate ammonia-lyase and EC 220.127.116.11, threo-3-hydroxy-L-aspartate ammonia-lyase. Requires a divalent cation such as Mn2+, Co2+ or Ni2+.
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:
1. Maeda, T., Takeda, Y., Murakami, T., Yokota, A. and Wada, M. Purification, characterization and amino acid sequence of a novel enzyme, D-threo-3-hydroxyaspartate dehydratase, from Delftia sp. HT23. J. Biochem. 148 (2010) 705-712. [PMID: 20843822]