Reaction: trans-anhydromevalonate 5-phosphate = 3-methylbut-3-en-1-yl phosphate + CO2
Glossary: trans-anhydromevalonate 5-phosphate = (2E)-3-methyl-5-phosphooxypent-2-enoate
3-methylbut-3-en-1-yl phosphate = isopentenyl phosphate
Systematic name: trans-anhydromevalonate 5-phosphate carboxy-lyase
Comments: The enzyme catalyses a step in the archaeal prenyl diphosphate biosynthesis pathway. It requires a prenylated flavin cofactor that is produced by EC 2.5.1.129, flavin prenyltransferase.
Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:
References:
1. Yoshida, R., Yoshimura, T. and Hemmi, H. Reconstruction of the "archaeal" mevalonate pathway from the methanogenic archaeon Methanosarcina mazei in Escherichia coli cells. Appl. Environ. Microbiol. 86 (2020) e02889-19. [PMID: 31924615]