IUBMB Enzyme Nomenclature

EC 2.5.1.129

Accepted name: flavin prenyltransferase

Reaction: dimethylallyl phosphate + FMNH2 = prenylated FMNH2 + phosphate

For diagram of reaction click here.

Glossary: prenylated FMNH2 = 3,3,4,5-tetramethyl-7-[(2S,3S,4R)-2,3,4-trihydroxy-5-(phosphonatooxy)pentyl]-2,3-dihydro-1H,7H-naphtho[1,8-fg]pteridine-9,11(8H,10H)-dione

Other name(s): ubiX (gene name); PAD1 (gene name)

Systematic name: dimethylallyl-phosphate:FMNH2 prenyltransferase

Comments: The enzyme produces the modified flavin cofactor prenylated FMNH2, which is required by EC 4.1.1.98, 4-hydroxy-3-polyprenylbenzoate decarboxylase, and EC 4.1.1.102, phenacrylate decarboxylase. The enzyme acts as a flavin prenyltransferase, linking a dimethylallyl moiety to the flavin N-5 and C-6 atoms and thus adding a fourth non-aromatic ring to the flavin isoalloxazine group.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. White, M.D., Payne, K.A., Fisher, K., Marshall, S.A., Parker, D., Rattray, N.J., Trivedi, D.K., Goodacre, R., Rigby, S.E., Scrutton, N.S., Hay, S. and Leys, D. UbiX is a flavin prenyltransferase required for bacterial ubiquinone biosynthesis. Nature 522 (2015) 502-506. [PMID: 26083743]

[EC 2.5.1.129 created 2015]


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