IUBMB Enzyme Nomenclature


Accepted name: mandelate 4-monooxygenase

Reaction: (S)-2-hydroxy-2-phenylacetate + tetrahydrobiopterin + O2 = (S)-4-hydroxymandelate + dihydrobiopterin + H2O

Glossary: (S)-4-hydroxymandelate = (S)-2-hydroxy-2-(4-hydroxyphenyl)acetate

Other name(s): L-mandelate 4-hydroxylase; mandelic acid 4-hydroxylase

Systematic name: (S)-2-hydroxy-2-phenylacetate,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)

Comments: Requires Fe2+.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 39459-82-0


1. Bhat, S.G. and Vaidyanathan, C.S. Purifications and properties of L-mandelate-4-hydroxylase from Pseudomonas convexa. Arch. Biochem. Biophys. 176 (1976) 314-323. [PMID: 9909]

[EC created 1984]

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