Wolfson Institute of Preventive Medicine - Barts and The London

Predictors studies

Centre for Cancer Prevention

Project Investigator:  Professor Jack Cuzick

Overview

This is a series of studies comparing the performance of different HPV and related molecular tests in detecting high grade CIN in a screening or referral context.  

Predictors 1 and 2 looked at approximately 2,000 women referred for abnormal cytology.  

Predictors 3 examined 6,000 residual ThinPrep samples from women attending routine screening.  

Predictors 4 compared collection in ThinPrep versus SurePath in 630 women referred for an abnormal smear. A subset of participants also provided a urine sample for testing. 

Predictors 5 is looking at a range of questions related to self-sampling:

Predictors 5.0 was a preparatory project (60 women) examining the stability of two self-sampling devices under various storage temperature conditions.

Predictors 5.1 is comparing four self-sampling devices plus urine collection in 600 women referred for abnormal cytology.

Publications

Individual detection of 14 high risk human papilloma virus genotypes by the PapType test for the prediction of high grade cervical lesions. J Clin Virol. 2014 Feb 14;60:44-9
Cuzick J, Ho L, Terry G, Kleeman M, Giddings M, Austin J, Cadman L, Ashdown-Barr L, Costa M, Szarewski A.

Comparison of human papillomavirus testing strategies for triage of women referred with low-grade cytological abnormalities. Eur J Cancer. 2013 Jun;49(9):2179-86.
Mesher D, Szarewski A, Cadman L, Austin J, Ashdown-Barr L, Ho L, Terry G, Young M, Stoler M, Bergeron C, McCarthy J, Wright C, Liddle S, Soutter WP, Lyons D, Cuzick J.

Comparing the performance of six human papillomavirus tests in a screening population. Br J Cancer. 2013 Mar 5;108(4):908-13.
Cuzick J, Cadman L, Mesher D, Austin J, Ashdown-Barr L, Ho L, Terry G, Liddle S, Wright C, Lyons D, Szarewski A.

Comparison of seven tests for high grade cervical intraepithelial neoplasia in women with abnormal smears: the Predictors 2 study. J Clin Microbiol. 2012 Jun;50(6):1867-73.
Szarewski A, Mesher D, Cadman L, Austin J, Ashdown-Barr L, Ho L, Terry G, Liddle S, Young M, Stoler M, McCarthy J, Wright C, Bergeron C, Soutter WP, Lyons D, Cuzick J.

Performance of the Abbott RealTime high-risk HPV test in women with abnormal cervical cytology smears. J Med Virol. 2010 Jul;82(7):1186-91.
Cuzick J, Ambroisine L, Cadman L, Austin J, Ho L, Terry G, Liddle S, Dina R, McCarthy J, Buckley H, Bergeron C, Soutter WP, Lyons D, Szarewski A.

Comparison of Predictors for High-Grade Cervical Intraepithelial Neoplasia in Women with Abnormal Smears. Cancer Epidemiol Biomarkers Prev. 2008 Nov;17(11):3033-42.
Szarewski A, Ambroisine L, Cadman L, Austin J, Ho L, Terry G, Liddle S, Dina R, McCarthy J, Buckley H, Bergeron C, Soutter P, Lyons D, Cuzick J.

Performance and Diagnostic Accuracy of a Urine-Based Human Papillomavirus Assay in a Referral Population Cancer Epidemiol Biomarkers Prev 2017;26(7):1053-1059.
Cuzick J, Cadman L, Ahmad A, Ho L, Terry G, Kleeman M, Lyons D, Austin J, Stoler M, Vibat CRT, Dockter J, Robbins D, Billings P, Erlander M.

A comparison of different human papillomavirus tests in PreservCyt versus SurePath in a referral population – PREDICTORS 4 (2016) J Clin Virol 82:145-51.
Cuzick J, Ahmad A, Austin J, Cadman L, Ho L, Terry G, Kleeman M, Ashdown-Barr L, Lyons D, Stoler M, Szarewski A.