INTERACT is a randomised controlled clinical trial assessing the effectiveness of programmed text message reminders on adherence to cardiovascular disease preventive medication.
- 50% of randomised patients will receive a Text Message Programme of periodic medication reminders plus standard care (interventional group)
- 50% of randomised patients will receive standard care alone (control group)
Trial Sponsor: Queen Mary University of London
Co-ordinating Centre: Wolfson Institute of Preventive Mediicine, Barts and the London School of Medicine
Coronary heart disease (CHD) is the world’s leading cause of death. Approximately one third of all deaths in England and Wales are due to CHD.
Combination drug therapy with blood pressure and serum cholesterol lowering drugs is effective in reducing the risk of first cardiovascular disease events; about ¾ of all heart attacks and strokes could be prevented with complete adherence to treatment. [PDF 269KB]
Non-adherence to medications is however common for patients with cardiovascular diseases and greatly reduces the preventive effect. An estimated 50% of patients do not take their tablets as prescribed.
- A randomised parallel group trial design, involving the enrolment of about 300 patients from General Practices in London.
- Patients prescribed either cholesterol lowering or blood pressure lowering medications (or both), are randomly assigned to two groups, about 150 receiving periodic Text Message Reminders and about 150 are not. Patients are followed up at their GP practice at 6 and 18 months.
- Continuation rate: The proportion of patients in each trial arm remaining on prescribed cholesterol or blood pressure lowering treatment.
- Number of days in the last month of the study that patients missed taking their medication.
- Serum cholesterol and blood pressure levels, in each arm at the end of follow up.
Text Messaging Programme Software
Text Scheduling takes three simple steps:
Step 1: Register the patient by entering their name and mobile phone number
Fig 1: Enter patient demographic details and mobile phone number
Step 2: Assign the patient to a text message group (allocated by time of their medication reminder's)
Fig 2: Patient groups are listed by times. Select a timed group or create a new one to assign the patient to a particular group.
Step 3: Assign the patient to a text message group (allocated by time of their medication reminder's)
Fig 3: Once the registered patient is selected, their schedule can be created in the ‘Text Message Method’ section.
The software application generates an adherence report for each patient based on the responses received over the previous quarter (time period can be customised). The chart below gives an example of a moderately adherent patient.
- David Wald
- Shahena Butt
Lower Clapton Health Centre, Hackney
Lead GP: Dr. Nick Brewer
Sorsby Medical Practice, Homerton,
Lead, GP: Dr. Nick Brewer
The Lea Surgery, Homerton
Lead GP: Dr. Ajay Goel
Jubilee Street, Whitechapel
Lead GP: Dr. Salma Ahmed
The Neaman Practice, Barbican
Lead GP: Dr. Caron Loh
The Nightingale Practice, Hackney
Lead GP: Dr. Nisha Patel
The Lawson Practice, Hoxton
Lead GP: Dr. Jonathon Gore
Paxton Green Group Practice, Gypsy Hill
Dr. Gillian Ellsbury