Wolfson Institute of Preventive Medicine - Barts and The London

Parkinson's Disease

The Parkinson’s disease (PD) programme of work at the Preventive Neurology Unit focuses on early identification and environmental, clinical and genetic determinants of PD.

One of the main studies is PREDICT-PD, which is coordinated and run by QMUL and UCL.

PREDICT-PD is a large cohort study that aims to identify those in the earliest stages of Parkinson’s, who may one day benefit from drugs that could slow or even halt the disease.

 Alongside PREDICT-PD there are a variety of other observational studies, in the phases of PD both pre-diagnosis and post-diagnosis, including:

  • The East London GP database/ Discovery platform – assessing new and known risk factors for PD.
  • The East London PD Project – a case-control study undertaking detailed clinical phenotyping, genotyping and biomarker studies, with a particular emphasis on ethnic differences in PD.
  • Genetic epidemiology and the use of common genetic variation to estimate the nature of causal relationships between a variety of risk factors and PD (so-called Mendelian randomisation). This work is undertaken using data from publicly available genome wide association studies and data from the UK Biobank study, in collaboration with the International Parkinson’s Disease Genomics Consortium and 23andMe.