Profile
Alastair is a Clinical Senior Lecturer in the Preventive Neurology Unit at the Wolfson Institute of Preventive Medicine, Queen Mary University of London, and a Consultant Neurology Registrar at Barts Health NHS Trust. His main research interests are Parkinson’s disease and related neurodegenerative disorders, particularly early identification and epidemiology, including environmental, clinical and genetic determinants. His other interests include objective measurement of motor and non-motor features of Parkinson’s.
Since 2011 he has led the PREDICT-PD study, which is a large cohort study that aims to identify those in the earliest stages of Parkinson’s, who may one day benefit from drugs that could slow or even halt the disease. Alongside PREDICT-PD he works on a variety of other observational studies, in the phases of Parkinson’s disease both pre-diagnosis and post-diagnosis. He has nurtured an interest in genetic epidemiology and the use of common genetic variation to estimate the nature of causal relationships between a variety of risk factors and Parkinson’s (so-called Mendelian randomisation).
Alastair has a strong collaborative network, which includes collaborators at UCL, Bristol University, the National Institutes of Health, and 23andMe. He is a member of the International Parkinson’s Disease Genomics Consortium, Association of British Neurologists, American Academy of Neurology, Movement Disorders Society, and the Parkinson’s UK Cohort Studies Council.
Publications
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Bestwick JP, Auger SD, Simonet C et al. (2021). Improving estimation of Parkinson's disease risk-the enhanced PREDICT-PD algorithm.. nameOfConference
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Jensen MP, Jacobs BM, Dobson R et al. (2021). Lower Lymphocyte Count is Associated With Increased Risk of Parkinson's Disease.. nameOfConference
DOI: 10.1002/ana.26034
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Jitlal M, Amirthalingam G, Karania T et al. (publicationYear). The influence of socioeconomic deprivation on dementia mortality, age at death and quality of diagnosis: a nationwide death records study in England and Wales 2001-2017. nameOfConference
DOI: 10.3233/JAD-210089
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Kang X, Ploner A, Pedersen NL et al. (2021). Tumor Necrosis Factor Inhibition and Parkinson Disease: A Mendelian Randomization Study. nameOfConference
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Senkevich K, Bandres-Ciga S, Yu E et al. (2021). No Evidence for a Causal Relationship Between Cancers and Parkinson's Disease.. nameOfConference
DOI: 10.3233/JPD-202474
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Cristina Simonet A, Noyce AJ (2021). Domotics, Smart Homes, and Parkinson's Disease.. nameOfConference
DOI: 10.3233/JPD-202398
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Global Parkinson's Genetics Program (2021). GP2: The Global Parkinson's Genetics Program.. nameOfConference
DOI: 10.1002/mds.28494
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Noyce AJ, Klein C (2021). Genetic Risk of Alzheimer's Disease - Sleepless with the Enemy.. nameOfConference
DOI: 10.1002/ana.25938
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Smeyne RJ, Noyce AJ, Byrne M et al. (2021). Infection and Risk of Parkinson's Disease.. nameOfConference
DOI: 10.3233/JPD-202279
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Chohan H, Senkevich K, Patel RK et al. (2021). Type 2 Diabetes as a Determinant of Parkinson's Disease Risk and Progression. nameOfConference
DOI: 10.1002/mds.28551
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Blauwendraat C, Makarious MB, Leonard HL et al. (publicationYear). A population scale analysis of rare SNCA variation in the UK Biobank. nameOfConference
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Foote IF, Jacobs BM, Noyce AJ et al. (2020). Exploring the shared genetic architecture of modifiable risk factors and related endophenotypes of Alzheimer’s disease: A genomic SEM study. nameOfConference
DOI: 10.1002/alz.045164
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Iwaki H, Blauwendraat C, Leonard HL et al. (2020). Differences in the Presentation and Progression of Parkinson's Disease by Sex. nameOfConference
DOI: 10.1002/mds.28312
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Auger SD, Jacobs BM, Dobson R et al. (2020). Big data, machine learning and artificial intelligence: a neurologist's guide.. nameOfConference
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Auger S, Jacobs B, Dobson R et al. (2020). Navigating a world of big data, machine learning and artificial intelligence: a neurologist's guide. nameOfConference
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Jacobs B, Belete D, Bestwick J et al. (2020). Parkinson’s disease determinants, prediction and gene-environment interactions in the UK Biobank. nameOfConference
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Mencacci NE, Reynolds R, Ruiz SG et al. (2020). Dystonia genes functionally converge in specific neurons and share neurobiology with psychiatric disorders. nameOfConference
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Cheong J, Goh Z, Marras C et al. (2020). The impact of COVID-19 on access to Parkinson’s disease medication. nameOfConference
DOI: 10.1002/mds.28293
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Noyce A (publicationYear). Evaluating lipid-lowering drug targets for Parkinson’s disease prevention with Mendelian randomization. nameOfConference
DOI: 10.1002/ana.25880
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Jacobs B, Taylor T, Awad A et al. (2020). Summary-data-based mendelian randomisation prioritises potential druggable targets for Multiple Sclerosis. nameOfConference
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Noyce A (2020). Large-scale pathway specific polygenic risk and transcriptomic community network analysis identifies novel functional pathways in Parkinson disease. nameOfConference
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Marini K, Mahlknecht P, Tutzer F et al. (publicationYear). Application of a Simple Parkinson's Disease Risk Score in a Longitudinal Population‐Based Cohort. nameOfConference
DOI: 10.1002/mds.28127
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Cheong J, de Pablo-Fernandez E, Foltynie T et al. (publicationYear). The association between type 2 diabetes mellitus and Parkinson’s disease. nameOfConference
DOI: 10.3233/JPD-191900
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Dobson R, Jitlal M, Marshall CR et al. (2020). Ethnic and Socioeconomic Associations with Multiple Sclerosis Risk. nameOfConference
DOI: 10.1002/ana.25688
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Auger S, Noyce A (publicationYear). Testing shortened versions of smell tests to screen for hyposmia in Parkinson’s disease. nameOfConference
DOI: 10.1002/mdc3.12928
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Dobson R, Noyce A, Giovannoni G et al. (2020). BMI and low serum vitamin D are causal risk factors for Multiple Sclerosis: a Mendelian Randomisation study. nameOfConference
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Alarcón F, Maldonado J-C, Cañizares M et al. (2020). Motor Dysfunction as a Prodrome of Parkinson's Disease.. nameOfConference
DOI: 10.3233/JPD-191851
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Jacobs BM, Smets I, Giovannoni G et al. (2020). Regarding: Nicotinic acetylcholine receptors α7 and α9 modify tobacco smoke risk for multiple sclerosis. nameOfConference
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Noyce A, Ben-Joseph A, MARSHALL C et al. (publicationYear). Ethnic variation in the manifestation of Parkinson’s disease: a narrative review. nameOfConference
DOI: 10.3233/JPD-191763
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Simonet C, Schrag A, Lees AJ et al. (2019). The motor prodromes of parkinson's disease: from bedside observation to large-scale application.. nameOfConference
QMRO: qmroHref -
Nalls MA, Blauwendraat C, Vallerga CL et al. (2019). Identification of novel risk loci, causal insights, and heritable risk for Parkinson's disease: a meta-analysis of genome-wide association studies. nameOfConference
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Noyce AJ, Bandres-Ciga S, Kim J et al. (2019). The Parkinson's Disease Mendelian Randomization Research Portal. nameOfConference
DOI: 10.1002/mds.27873
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Noyce A, International Parkinson¿s Disease Genomics Consortium (IPDGC) (2020). Genetic modifiers of risk and age at onset in GBA associated Parkinson’s disease and Lewy body dementia. nameOfConference
DOI: 10.1093/brain/awz350
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Bandres-Ciga S, Noyce A, Traynor BJ (publicationYear). Mendelian randomization: a journey from obscurity to center stage with a few potholes along the way. nameOfConference
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Noyce A, Iwaki H (2019). Genomewide association study of Parkinson's disease clinical biomarkers in 12 longitudinal patients' cohorts. nameOfConference
DOI: 10.1002/mds.27845
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Neligan A, Noyce AJ, Gosavi TD et al. (2019). Change in Mortality of Generalized Convulsive Status Epilepticus in High-Income Countries Over Time. nameOfConference
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Iwaki H, Blauwendraat C, Leonard HL et al. (2019). Genetic risk of Parkinson disease and progression: An analysis of 13 longitudinal cohorts. nameOfConference
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Joseph T, Auger SD, Peress L et al. (2019). Screening performance of abbreviated versions of the UPSIT smell test. nameOfConference
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Hasan H, Burrows M, Athauda DS et al. (2019). The BRadykinesia Akinesia INcoordination (BRAIN) Tap Test: Capturing the Sequence Effect.. nameOfConference
DOI: 10.1002/mdc3.12798
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NOYCE AJ, Neligan A, Gosavi T et al. (2019). Change in Mortality of Generalized Convulsive Status Epilepticus in High-Income Countries Over Time A Systematic Review and Meta-analysis. nameOfConference
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NOYCE AJ, International Parkinson's Disease Genomics Consortium (IPDGC) (2019). Parkinson's disease age at onset genome-wide association study: Defining heritability, genetic loci, and α-synuclein mechanisms.. nameOfConference
DOI: 10.1002/mds.27659
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Heilbron K, NOYCE AJ, Fontanillas P et al. (2019). The Parkinson’s Phenome—Traits Associated with Parkinson's Disease in a Broadly Phenotyped Cohort. nameOfConference
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Schrag A, Anastasiou Z, Ambler G et al. (publicationYear). Predicting Diagnosis of Parkinson’s disease: A Risk Algorithm based on Primary Care presentations. nameOfConference
DOI: 10.1002/mds.27616
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NOYCE AJ (2019). Shared polygenic risk and causal inferences in amyotrophic lateral sclerosis. nameOfConference
DOI: 10.1002/ana.25431
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NOYCE AJ, Rees R, Schrag A (2018). The prodromes of Parkinson's disease.. nameOfConference
DOI: 10.1111/ejn.14269
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Acharya A, Basnett I, Gutteridge C et al. (2018). Laughter isn't always the best medicine.. nameOfConference
DOI: 10.1136/bmj.k4579
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Rees RN, Acharya AP, Schrag A et al. (2018). An early diagnosis is not the same as a timely diagnosis of Parkinson's disease. nameOfConference
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NOYCE AJ (2018). Mendelian randomization study shows no causal relationship between circulating urate levels and Parkinson’s disease.. nameOfConference
DOI: 10.1002/ana.25294
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De Pablo-Fernandez E, Goldacre R, Pakpoor J et al. (2018). Association between diabetes and subsequent Parkinson disease: A record-linkage cohort study.. nameOfConference
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Noyce A (2018). Remembering the man behind An Essay on the Shaking Palsy. nameOfConference
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Keddie S, Adams A, Kelso ARC et al. (2018). No laughing matter: subacute degeneration of the spinal cord due to nitrous oxide inhalation. nameOfConference
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Weil RS, Schwarzkopf DS, Bahrami B et al. (2018). Assessing cognitive dysfunction in Parkinson's disease: An online tool to detect visuo-perceptual deficits.. nameOfConference
DOI: 10.1002/mds.27311
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Shribman S, Noyce A, Gnanapavan S et al. (2018). Cryptococcal meningitis in apparently immunocompetent patients: association with idiopathic CD4+ lymphopenia.. nameOfConference
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Blauwendraat C, Kia DA, Pihlstrøm L et al. (2018). Insufficient evidence for pathogenicity of SNCA His50Gln (H50Q) in Parkinson's disease. nameOfConference
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Noyce AJ, Dickson J, Rees RN et al. (2018). Dopamine reuptake transporter-single-photon emission computed tomography and transcranial sonography as imaging markers of prediagnostic Parkinson's disease.. nameOfConference
DOI: 10.1002/mds.27282
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NOYCE AJ (2018). Assessing cognitive dysfunction in Parkinson’s: An online tool to detect visuo-perceptual deficits. nameOfConference
DOI: 10.1002/mds.27311
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Shribman S, Hasan H, Hadavi S et al. (2018). The BRAIN test: a keyboard-tapping test to assess disability and clinical features of multiple sclerosis.. nameOfConference
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Noyce AJ, Lees A (2017). Observations on a 2-Step Approach to Screening for Parkinson Disease. nameOfConference
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Noyce A, Bandopadhyay R (2017). Parkinson's Disease: Basic Pathomechanisms and a Clinical Overview.. nameOfConference
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Raciborska DD, Noyce AJ, Pyne D et al. (publicationYear). Lupus myelopathy. nameOfConference
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Lynch DS, Loh SHY, Harley J et al. (2017). Nonsyndromic Parkinson disease in a family with autosomal dominant optic atrophy due to OPA1 mutations. nameOfConference
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Noyce AJ, Kia DA, Hemani G et al. (2017). Estimating the causal influence of body mass index on risk of Parkinson disease: A Mendelian randomisation study. nameOfConference
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Noyce A, Kia D, Hemani G et al. (2017). Increased BMI May Protect against Parkinson's Disease: Evidence From Mendelian Randomisation Study. nameOfConference
DOI: doi
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Pakpoor J, Noyce A, Goldacre R et al. (2017). Viral hepatitis and Parkinson disease: A national record-linkage study.. nameOfConference
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Magdalinou NK, Noyce AJ, Pinto R et al. (2017). Identification of candidate cerebrospinal fluid biomarkers in parkinsonism using quantitative proteomics. nameOfConference
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Noyce AJ, Schrag A, Masters JM et al. (2017). Subtle motor disturbances in PREDICT-PD participants.. nameOfConference
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Hasan H, Athauda DS, Foltynie T et al. (2017). Technologies Assessing Limb Bradykinesia in Parkinson’s Disease. nameOfConference
DOI: 10.3233/JPD-160878
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Noyce AJ, R'Bibo L, Peress L et al. (2017). PREDICT-PD: An online approach to prospectively identify risk indicators of Parkinson's disease.. nameOfConference
DOI: 10.1002/mds.26898
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Lubbe SJ, Escott-Price V, Gibbs JR et al. (publicationYear). Additional rare variant analysis in Parkinson’s disease cases with and without known pathogenic mutations: evidence for oligogenic inheritance. nameOfConference
DOI: 10.1093/hmg/ddw348
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Adams-Carr KL, Bestwick JP, Shribman S et al. (2016). Constipation preceding Parkinson's disease: a systematic review and meta-analysis.. nameOfConference
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Salat D, Noyce AJ, Schrag A et al. (2016). Challenges of modifying disease progression in prediagnostic Parkinson's disease. nameOfConference
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Mok KY, Sheerin U, Simón-Sánchez J et al. (2016). Deletions at 22q11.2 in idiopathic Parkinson's disease: a combined analysis of genome-wide association data. nameOfConference
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Noyce AJ, Nalls MA (2016). Mendelian Randomization - the Key to Understanding Aspects of Parkinson's Disease Causation?. nameOfConference
DOI: 10.1002/mds.26492
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Noyce AJ, Lees AJ, Schrag A-E (2016). The prediagnostic phase of Parkinson's disease. nameOfConference
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Masters JM, Bestwick J, Warner TT et al. (2015). Systematic review and meta-analysis of salivary protein concentration in Parkinson's disease.. nameOfConference
DOI: 10.1002/mds.26462
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Adams-Carr K, Schrag A, Shribman S et al. (2015). CONSTIPATION PRECEDING PARKINSON'S DISEASE–META-ANALYSIS. nameOfConference
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Masters J, Noyce A, Giovannoni G et al. (2015). ELEVATED SALIVARY DJ-1 IN PARKINSON'S DISEASE IS ASSOCIATED WITH ALTERED SALIVARY SECRETION. nameOfConference
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Nalls MA, McLean CY, Rick J et al. (2015). Diagnosis of Parkinson's disease on the basis of clinical and genetic classification: a population-based modelling study.. nameOfConference
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Masters JM, Noyce AJ, Warner TT et al. (2015). Elevated salivary protein in Parkinson's disease and salivary DJ-1 as a potential marker of disease severity.. nameOfConference
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Nagy A, Noyce A, Velayos-Baeza A et al. (2015). Late Emergence of Parkinsonian Phenotype and Abnormal Dopamine Transporter Scan in Chorea-Acanthocytosis.. nameOfConference
DOI: 10.1002/mdc3.12138
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Noyce AJ, Mencacci NE, Schrag A et al. (2015). Web-based assessment of Parkinson's prodromal markers identifies GBA variants.. nameOfConference
DOI: 10.1002/mds.26249
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Schrag A, Horsfall L, Walters K et al. (2015). Prediagnostic presentations of Parkinson's disease in primary care: a case-control study.. nameOfConference
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Torsney KM, Noyce AJ, Doherty KM et al. (2014). Bone health in Parkinson's disease: a systematic review and meta-analysis.. nameOfConference
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Osborne C, Noyce A, Sylvester R (2014). AUTO-REGULATION ICP IN IIH DUE TO CHRONIC CSF LEAK. nameOfConference
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Mencacci NE, Isaias IU, Reich MM et al. (2014). Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.. nameOfConference
DOI: 10.1093/brain/awu179
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Staff TPO (2014). Correction: Bradykinesia-Akinesia Incoordination Test: Validating an Online Keyboard Test of Upper Limb Function. nameOfConference
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Osborne C, Stallworthy S, Evanson J et al. (2014). Rapid-onset flaccid paraplegia caused by multiple myeloma dumbbell tumour.. nameOfConference
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Shribman S, Torsney KM, Noyce AJ et al. (2014). A service development study of the assessment and management of fracture risk in Parkinson's disease.. nameOfConference
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Nalls MA, Saad M, Noyce AJ et al. (2014). Genetic comorbidities in Parkinson's disease. nameOfConference
DOI: 10.1093/hmg/ddt465
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Noyce AJ, Nagy A, Acharya S et al. (2014). Bradykinesia-akinesia incoordination test: validating an online keyboard test of upper limb function.. nameOfConference
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Noyce AJ, Bestwick JP, Silveira-Moriyama L et al. (2014). PREDICT-PD: Identifying risk of Parkinson's disease in the community: Methods and baseline results. nameOfConference
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Hadavi S, Shribman S, Nagy A et al. (2013). The bradykinesia-akinesia incoordination test: a simple objective test in multiple sclerosis.. nameOfConference
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Dobson R, Yarnall A, Noyce AJ et al. (2013). Bone health in chronic neurological diseases: a focus on Multiple sclerosis and Parkinsonian syndromes.. nameOfConference
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Djamshidian A, O'Sullivan SS, Foltynie T et al. (2013). Dopamine agonists rather than deep brain stimulation cause reflection impulsivity in Parkinson's disease.. nameOfConference
DOI: 10.3233/JPD-130178
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Noyce AJ, Bestwick JP, Silveira-Moriyama L et al. (2012). Meta-analysis of early nonmotor features and risk factors for Parkinson disease.. nameOfConference
DOI: 10.1002/ana.23687
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Chan MV, Bubb KJ, Noyce A et al. (2012). Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation.. nameOfConference
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Noyce A, Silveira-Moriyama L, Lees AJ et al. (2012). A PILOT STUDY OF AN ALGORITHM DESIGNED TO IDENTIFY PARKINSON'S DISEASE IN THE EARLY, NON-MOTOR PHASE. nameOfConference
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Noyce A, Bestwick J, Hawkes CH et al. (2012). AN ALGORITHM TO IDENTIFY INDIVIDUALS AT HIGH-RISK OF PARKINSON'S DISEASE IN THE COMMUNITY. nameOfConference
QMRO: qmroHref -
Doherty KM, Noyce AJ, Silveira-Moriyama L et al. (2012). Familial camptocormia: from dystonia to myopathy.. nameOfConference
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Noyce AJ, Silveira-Moriyama L, Gilpin P et al. (2012). Severe dysphagia as a presentation of Parkinson's disease.. nameOfConference
DOI: 10.1002/mds.24006
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Noyce A, Treacy C, Budu C et al. (2012). THE NEW BRADYKINESIA AKINESIA INCOORDINATION (BRAIN) TEST: AN ONLINE TEST OF UPPER LIMB MOVEMENT. nameOfConference
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Doherty KM, Silveira-Moriyama L, Nisbet A et al. (2012). 0854 Camptocormia: what is the cause?. nameOfConference
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Noyce AJ, Treacy C, Budu C et al. (2012). The new Bradykinesia Akinesia Incoordination (BRAIN) test: preliminary data from an online test of upper limb movement.. nameOfConference
DOI: 10.1002/mds.23947
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Hadavi S, Noyce AJ, Leslie RD et al. (2011). Stiff person syndrome.. nameOfConference
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Noyce AJ, McCrae S, Gawler J et al. (2010). Teaching NeuroImages: microhemorrhages resulting from cranial radiotherapy in childhood.. nameOfConference
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Shah M, Deeb J, Fernando M et al. (2009). Abnormality of taste and smell in Parkinson's disease.. nameOfConference
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