Helicobacter pylori is a bacterial infection that increases the risk of stomach cancer. The aim of this study is to find out whether screening for and eradicating H. pylori infection in healthy middle aged people can reduce the subsequent incidence of stomach cancer.
62,454 men aged 35-69 and women aged 45-69 who attended a Bupa Wellness Centre for a health screen between July 1997 and January 2006.
Participants were randomly allocated to one of two groups. Participants in one group were tested for H. pylori and, if found to be infected, were offered a one-week course of drug treatment to eradicate the infection (oral metronidazole, clarithromycin and lansoprazole). Participants in the other group did not receive any screening or treatment. Death certificate and cancer registrations are received from NHS Digital on all participants to assess the incidence of deaths from stomach cancer.
April 1997 to January 2030
Cancer Research UK (CRUK) are currently funding this follow-up stage of the trial.