Skip to main content
Wolfson Institute of Population Health - Barts and The London

Louise Mary Cadman

28th January 1965 - 7th November 2020

It was with great sadness that we learnt that Louise Cadman passed away on 7 November 2020,  after a long battle with malignant melanoma. She was comfortable, not in pain, and had her family around her, as she had wanted.

Louise joined my team at ICRF in 1994 as a specialist nurse practitioner, and moved with us to the Wolfson in 2002. Her work focused on projects related to HPV and cervix cancer. Aside from her central role in conducting our numerous cervical screening studies, she became particularly well known for her work on self-sampling and patient views on screening.

Some of the early work was done at the Whittington Hospital with Professors Albert Singer and Dennis McCance, and followed shortly after Herald Hausen’s  ground breaking discovery of the central role of HPV  as the causative agent for cervix cancer, for which he received the Nobel Prize. Louise worked closely with Anne Szarewski, and together they formed an amazing clinical team, which produced a large number of key studies, some of which are listed below. Early work focused on establishing the role of HPV testing as a useful screening modality, using some of the original HPV tests, which were very tedious and laborious to perform. One of the first major screening studies was done at the Margaret Pyke Centre, and its success led to the more definitive randomised HART trial conducted in 11,085 women attending screening in 161 family practices associated with five referral centres in the UK. In this study the HPV test was added to routine cytology and women with borderline cytology or negative cytology plus being HPV positive were randomly allocated to management by immediate colposcopy or repeat testing and colposcopy at 12 months. This, and subsequent studies, led to the widespread adoption of HPV testing as the preferred primary screening test. It also led to an explosion of commercially available HPV tests, and our PREDICTORS studies, of which there are now five, were the only set of studies to look at a wide range of HPV tests in the same woman, initially in a referral population, but subsequently in the screening context, and more recently for self sampling. These studies confirmed that very similar results were obtained in a range of HPV DNA tests, and also provided some of the first evidence that the Aptima RNA test was as sensitive as the DNA tests for CIN3+, but importantly was more specific in that there were fewer positive results in women without disease, thus avoiding unnecessary colposcopic referral. Self sampling has more recently emerged as an attractive option for cervical screening, and one of the first studies of this was our 2007 paper in almost 1000 women attending screening. Work on self-sampling is still ongoing, and challenges remain as to how to best invite women for self-screening, and which methods are most effective. Our early 2007 results have now been confirmed in many studies, and our most recent paper, in which Louise took the lead, examined a range of vaginal collection devices plus urine to determine how best to undertake self-sampling. We also conducted a large study of non-responders to routine screening invitations to determine willingness for self-sampling. This work reflects Louise’s major interest in understanding the patient’s views about cervical screening. Of particular note are her studies on the perception of screening among ethnic minorities, and among women who have undergone sexual abuse.

Louise’s contribution to the scientific output of the department has been enormous, and much of this work would not have been undertaken without her continued devotion. She was also a great colleague and dear friend to many of us at the Wolfson Institute. I personally will miss her pleasant smile and willingness to help wherever needed. She is irreplaceable and will be sorely missed.

 

Jack Cuzick, Wolfson Institute of Preventive Medicine

                                                                                                                                                                                      

References

Human papillomavirus testing in primary cervical screening. Cuzick J, Szarewski A, Terry G, Ho L, Hanby A, Maddox P, Anderson M, Kocjan G, Steele ST & Guillebaud J. Lancet 1995, 345: 1533-1536

 

Management of women who test positive for high-risk types of human papillomavirus: the HART study. Cuzick J, Szarewski A, Cubie H, Hulman G, Kitchener H, Luesley D, McGoogan E, Menon U, Terry G, Edwards R, Brooks C, Desai M, Gie C, Ho L, Jacobs I, Pickles C, Sasieni P. Lancet, 2003, 362: 1871-1876

 

Awareness of human papillomavirus among women attending a well woman clinic  J Waller, K McCaffery, S Forrest, A Szarewski, L Cadman, J Wardle. Sex Transm Infect, 2003 Aug; 79(4): 320–322 

 

Attitudes to self-sampling for HPV among Indian, Pakistani, African-Caribbean and white British women in Manchester, UK  S Forrest, K McCaffery, J Waller, M Desai, A Szarewski, L Cadman, J Wardle. J Med Screen, 2004 Jun 1; 11(2): 85–88 

 

Human papillomavirus testing by self-sampling: assessment of accuracy in an unsupervised clinical setting  Anne Szarewski, Louise Cadman, Susan Mallett, Janet Austin, Philip Londesborough, Jo Waller, Jane Wardle, Douglas G Altman, Jack Cuzick. J Med Screen, 2007 Mar 1; 14(1): 34–42 

 

Long-term follow-up of cervical disease in women screened by cytology and HPV testing: results from the HART study  D Mesher, A Szarewski, L Cadman, H Cubie, H Kitchener, D Luesley, U Menon, G Hulman, M Desai, L Ho, G Terry, A Williams, P Sasieni, J Cuzick. Br J Cancer, 2010 Apr 27; 102(9): 1405–1410 

 

HPV self-sampling as an alternative strategy in non-attenders for cervical screening – a randomised controlled trial  A Szarewski, L Cadman, D Mesher, J Austin, L Ashdown-Barr, R Edwards, D Lyons, J Walker, J Christison, A Frater, J Waller. Br J Cancer, 2011 Mar 15; 104(6): 915–920 

 

Barriers to cervical screening in women who have experienced sexual abuse: an exploratory study  Louise Cadman, Jo Waller, Lesley Ashdown-Barr, Anne Szarewski. J Fam Plann Reprod Health Care, 2012 Oct; 38(4): 214–220 

 

Comparison of Seven Tests for High-Grade Cervical Intraepithelial Neoplasia in Women with Abnormal Smears: the Predictors 2 Study  Anne Szarewski, David Mesher, Louise Cadman, Janet Austin, Lesley Ashdown-Barr, Linda Ho, George Terry, Stuart Liddle, Martin Young, Mark Stoler, Julie McCarthy, Corrina Wright, Christine Bergeron, W. P Soutter, Deirdre Lyons, Jack Cuzick. J Clin Microbiol, 2012 Jun; 50(6): 1867–1873 

 

Comparing the performance of six human papillomavirus tests in a screening population  J Cuzick, L Cadman, D Mesher, J Austin, L Ashdown-Barr, L Ho, G Terry, S Liddle, C Wright, D Lyons, A Szarewski. Br J Cancer, 2013 Mar 5; 108(4): 908–913

 

A DNA methylation classifier of cervical precancer based on human papillomavirus and human genes  Adam R Brentnall, Nataša Vasiljević, Dorota Scibior-Bentkowska, Louise Cadman, Janet Austin, Anne Szarewski, Jack Cuzick, Attila T Lorincz. Int J Cancer, 2014 Sep 15; 135(6): 1425–1432

 

Individual detection of 14 high risk human papilloma virus genotypes by the PapType test for the prediction of high grade cervical lesions  Jack Cuzick, Linda Ho, George Terry, Michelle Kleeman, Michael Giddings, Janet Austin, Louise Cadman, Lesley Ashdown-Barr, Maria J. Costa, Anne Szarewski. J Clin Virol, 2014 May; 60(1): 44–49 

 

Attitudes towards cytology and human papillomavirus self-sample collection for cervical screening among Hindu women in London, UK: a mixed methods study  Louise Cadman, Lesley Ashdown-Barr, Jo Waller, Anne Szarewski. J Fam Plann Reprod Health Care, 2015 Jan; 41(1): 38–47

 

Performance of the Xpert HPV assay in women attending for cervical screening  Jack Cuzick, K. Cuschieri, K. Denton, M. Hopkins, M.A. Thorat, C. Wright, H. Cubie, C. Moore, M. Kleeman, J. Austin, L. Ashdown-Barr, K. Hunt, L. Cadman. Papillomavirus Res, 2015 Dec; 1: 32–37 

 

Performance of a Cartridge-Based Assay for Detection of Clinically Significant Human Papillomavirus (HPV) Infection: Lessons from VALGENT (Validation of HPV Genotyping Tests)  Kate Cuschieri, Daan Geraets, Jack Cuzick, Louise Cadman, Catherine Moore, Davy Vanden Broeck, Elisaveta Padalko, Wim Quint, Marc Arbyn. J Clin Microbiol, 2016 Sep; 54(9): 2337–2342 

 

 

A comparison of different human papillomavirus tests in PreservCyt versus SurePath in a referral population—PREDICTORS 4  Jack Cuzick, Amar S. Ahmad, Janet Austin, Louise Cadman, Linda Ho, George Terry, Michelle Kleeman, Lesley Ashdown-Barr, Deirdre Lyons, Mark Stoler, Anne Szarewski. J Clin Virol, 2016 Sep; 82: 145–151

 

Validation of a DNA methylation HPV triage classifier in a screening sample  Attila T. Lorincz, Adam R. Brentnall, Dorota Scibior‐Bentkowska, Caroline Reuter, Rawinder Banwait, Louise Cadman, Janet Austin, Jack Cuzick, Natasa Vasiljević. Int J Cancer, 2016 Jun 1; 138(11): 2745–2751

 

A randomised comparison of different vaginal self-sampling devices and urine for human papillomavirus testing – Predictors 5.1   Cadman L, Reuter C, Jitlal M, Kleeman M, Austin J, Hollingworth T, Parberry A, Ashdown-Barr L, Patel D, Nedjai B, Lorincz A, Cuzick J. (IN PRESS 2020) Cancer Epidemiology, Biomarkers and Prevention