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The William Harvey Research Institute - Barts and The London

Dr Suchita Nadkarni

Suchita

British Heart Foundation Research Fellow and Lecturer in Immunology

Centre: Biochemical Pharmacology

Email: s.nadkarni@qmul.ac.uk
Telephone: +44(0) 20 7882 8235

Profile

Suchita obtained her BSc in Biomedical Science at King’s College London. She then went on to obtain her PhD at University College London, under the supervision of Profs Michael Ehrenstein and Claudia Mauri, where she investigated the role of regulatory T-cells in anti-TNF-treated rheumatoid arthritis patients. Following a brief post-doc in New York, Suchita left lab-based research for a year to work as a Senior Science Adviser to the Government. In 2009, She then returned to lab research, undertaking post-doc project with Prof Mauro Perretti at WHRI looking into the role of neutrophils in patients with Giant Cell Arteritis. It was during this time that Suchita developed her interests in neutrophils, combining it with her background in T-cell immunology. In 2013 Suchita joined Prof Federica Marelli-Berg’s group, where she developed her niche investigating the importance of neutrophil-T cell interactions during pregnancy.  In 2017 Suchita was awarded a 5-year intermediate research fellowship from the British Heart Foundation.

Research

Group members

Eleanor J Ward (Postdoctoral Researcher)

Summary 

Suchita’s work focuses on the role of the maternal immune system in shaping pregnancy outcomes. Suchita is specifically interested in how maternal neutrophils can influence T-cell responses and how such interactions can regulate placental development (see image) and her main disease area of interest is pre-eclampsia In addition to their roles in placental development, Suchita is also interested in how neutrophil-T cell interactions can influence maternal cardiovascular responses during pregnancy and fetal development.

The Placenta Rainbow  - Wellcome Image Award 2017 and National Geographic 2018

Placenta Rainbow

Using wide-field confocal scanning microscopy, The Placenta Rainbow, depicts 9 different mouse placentas that have been individually imaged and arranged in PhotoShop.  Each placenta derives from a distinct mouse pregnancy in which the mother’s immune system has been manipulated to assess the architecture of the placentas. Following extraction, the placentas are labelled with different coloured antibodies that bind to specific proteins.  The varying colours denotes specific structures within the placenta and allows us to assess whether manipulation of the mother’s immune system affects development of the placenta.  Such assessments could help identify targets for complications arising in human pregnancies.

 

Key Publications

ORCID iD: https://orcid.org/0000-0002-4549-3983

  • Nadkarni, S. et al. Identification of an activated neutrophil phenotype in polymyalgia rheumatica during steroid treatment: a potential involvement of immune cell cross-talk. Clinical science 133, 839-851, doi:10.1042/CS20180415 (2019).
  • Lashin, H. M. S. et al. Microvesicle Subsets in Sepsis Due to Community Acquired Pneumonia Compared to Faecal Peritonitis. Shock, doi:10.1097/SHK.0000000000000989 (2017).
  • Hebeda, C. B. et al. Endogenous annexin A1 (AnxA1) modulates early phase gestation and offspring sex-ratio skewing. Journal of cellular physiology, doi:10.1002/jcp.26258 (2017).
  • Nadkarni, S. et al. Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy. Proceedings of the National Academy of Sciences of the United States of America 113, E8415-E8424, doi:10.1073/pnas.1611944114 (2016).
  • Komarowska, I. et al. Hepatocyte Growth Factor Receptor c-Met Instructs T Cell Cardiotropism and Promotes T Cell Migration to the Heart via Autocrine Chemokine Release. Immunity 42, 1087-1099, doi:10.1016/j.immuni.2015.05.014 (2015).
  • Haas, R. et al. Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. PLOS Biol 13, e1002202, doi:10.1371/journal.pbio.1002202 (2015).
  • Old, E. A. et al. Monocytes expressing CX3CR1 orchestrate the development of vincristine-induced pain. The Journal of clinical investigation 124, 2023-2036, doi:10.1172/JCI71389 (2014).
  • Nadkarni, S. et al. Investigational analysis reveals a potential role for neutrophils in giant-cell arteritis disease progression. Circulation research 114, 242-248, doi:10.1161/CIRCRESAHA.114.301374 (2014).
  • Nadkarni, S. & McArthur, S. Oestrogen and immunomodulation: new mechanisms that impact on peripheral and central immunity. Current opinion in pharmacology 13, 576-581, doi:10.1016/j.coph.2013.05.007 (2013).
  • Spurr, L. et al. Comparative analysis of Annexin A1-formyl peptide receptor 2/ALX expression in human leukocyte subsets. International immunopharmacology 11, 55-66, doi:10.1016/j.intimp.2010.10.006 (2011).
  • Nadkarni, S., Cooper, D., Brancaleone, V., Bena, S. & Perretti, M. Activation of the annexin A1 pathway underlies the protective effects exerted by estrogen in polymorphonuclear leukocytes. Arteriosclerosis, thrombosis, and vascular biology 31, 2749-2759, doi:10.1161/ATVBAHA.111.235176 (2011).
  • Nadkarni, S., Mauri, C. & Ehrenstein, M. R. Anti-TNF-alpha therapy induces a distinct regulatory T cell population in patients with rheumatoid arthritis via TGF-beta. The Journal of experimental medicine 204, 33-39, doi:10.1084/jem.20061531 (2007). 

Collaborators

Internal

External

  • Dr Amanda Sferruzzi-Perri (University of Cambridge)
  • Dr Elena Greco (Barts Health)
  • Prof Justin Mason (Imperial College London)
  • Prof Bhaskar Dasgupta (Southend University Hospital)
  • Professor Mary Rutherford (King's College London)