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Dr Rayomand Khambata

Rayomand

Lecturer in Vascular Pharmacology

Centre: Cardiovascular Medicine and Devices

Email: r.khambata@qmul.ac.uk

Profile

ORCID iD: 0000-0001-6144-421X

Rayomand Khambata obtained a first-class undergraduate Masters in Pharmacology from the University of Bath in 2006. He then joined Professor Adrian Hobbs’ group at University College London and completed his PhD in pharmacology which involved investigating the role of C-type natriuretic peptide on vascular homeostasis. After obtaining his PhD in 2010 he started a post-doc with Professor Amrita Ahluwalia at the William Harvey Research Institute, to investigate the role of inorganic nitrate on atherosclerosis. During this time his research has focussed on the role of inorganic nitrate on the cardiovascular system, with a focus on inflammation. In 2020 he was appointed as a Lecturer. 

Rayomand is an academic advisor and module lead for Drug design, a 3rd year module on the BSc Pharmacology and Innovative Therapeutics programme. He is also involved in various teaching on the MBBS/Biomedical Sciences and Masters programmes. In 2021 he was appointed as Head of Year 3 for BSc Pharmacology & Innovative Therapeutics.

Rayomand leads the William Harvey Research Institute Work Experience Programme which was established in 2017.

Research

Vascular Pharmacology Group

Professor Amrita Ahluwalia (Head); Jonathan Ho (Lab Manager); Vikas Kapil (Clinical Senior Lecturer/Consultant); Dan Jones (Clinical Senior Lecturer and Consultant Cardiologist); Rayomand Khambata (Lecturer); Gianmichele Massimo (Post-Doctoral Researcher); Dr Claudio Raimondi (Lecturer); Dr Vahitha Abdul Salaam (Lecturer); Nicki Dyson (PhD student); Andrew Sullivan (Cardiology SpR)

Summary

The major focus of the Vascular Pharmacology group is the bioactivation of inorganic nitrate to nitrite and subsequently nitric oxide. My research focusses on the potential anti-inflammatory effects of inorganic nitrate and nitrite in the setting of cardiovascular diseases.

Key Publications

  1. Fernandes D†, Khambata RS†, Massimo G, Ruivo E, Gee LC, Foster J, Goddard A, Curtis M, Barnes MR, Wade WG, Godec T, Orlandi M, D’Aiuto F, Ahluwalia A. (2023) †Authors contributed equally to this work. Local delivery of nitric oxide prevents endothelial dysfunction in periodontitis. Pharmacological Research. 188, 106616, PMID: 36566926
  2. Bosseboeuf E, Chikh A, Chaker, AM, Mitchell, TP, Vignaraja D, Rajendrakumar R, Khambata RS, Nightingale, TD, Mason JC, Randi AM, Ahluwalia A, Raimondi C. (2023). Neuropilin-1 prevents endothelial activation and interacts with TGFBR2 and VE-cadherin to promote adherens junction stability. Science Signalling, 16, 786.
  3. Hamers A, Primus CP, Whitear C, Kumar N, Masucci M, Montalvo Moreira S, Rathod KS, Chen J, Bubb K, Colas R, Khambata RS, Dalli J, Ahluwalia A. (2022). 20-hydroxyeicosatetraenoic acid (20-HETE) is a pivotal endogenous ligand for TRPV1-mediated neurogenic inflammation in the skin. BJP. 179, 1450-1469.
  4. Gee LC, Massimo G, Lau C, Primus CP, Fernandes D, Chen J, Rathod KS, Hamers A, Filomena F, Nuredini G, Ibrahim AS, Khambata RS, Gupta AK, Moon JC, Kapil V, Ahluwalia A. (2022). Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxide. BJP. 179, 4757-4777.
  5. Shabbir A, Rathod KS, Khambata RS, Ahluwalia A. (2021) Sex Differences in the Inflammatory Response: Pharmacological Opportunities for Therapeutics for Coronary Artery Disease. Annu Rev Pharmacol Toxicol. 61, 333-359.

Teaching

Rayomand is the Head of Year 3 for BSc Pharmacology & Innovative Therapeutics and is module lead for ‘Drug design’ and ‘Research projects in Pharmacology’, which are both 3rd year modules. He is also involved in various teaching on the MBBS/Biomedical Sciences and Masters programmes and is an academic advisor to undergraduate students.

Disclosures

No disclosures.

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