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The William Harvey Research Institute - Barts and The London

New paper: Sestrins induce natural killer function in senescent-like CD8+ T cells


In a new joint study, published in Nature Immunology, researchers have found that ‘aged’ T cells are not a defective end-stage population but are reprogrammed to recognize and kill NK receptors, a process regulated by sestrins. 

The findings are important as preventing the signals may be a safe strategy to increase the number of antigen-specific T cells after vaccination to enhance immunity during aging. 

Read the full paper at