Project title: Targeting the G protein-coupled protein receptor, CB2, towards the development of novel anticancer therapeutics
Summary: G protein-coupled receptors (GPCRs) are the largest family of membrane proteins in humans. As a result, they are an attractive pharmacological target. Cannabinoid receptor 2 (CB2R) is a GPCR and is one of two cannabinoid receptors (CB1 and CB2) - both of which are closely related. Recent studies have found that CB2R is over-expressed in several types of cancer, therefore making it a suitable drug target. This project will involve the use of computational chemistry to identify and exploit a novel allosteric site on CB2R to then design and synthesise targeted compounds against the receptor. These compounds will then be tested in biological assays. Heterodimers involving CB2R will then be explored and peptide chemistry will be used to target these heterodimers, including CB2-CXCR4 and CB2-HER2, in order to target certain cancers.