Dr Lesley Howell

Senior Lecturer
Email: l.howell@qmul.ac.ukTelephone: +44 (0)20 7882 6625Room Number: Room G.03, Joseph Priestley building
Undergraduate Teaching
Module Organiser for Advanced Pharmaceutical Chemistry (CHE306U) and Professional Skills for Chemists (CHE401)
Teaches on:
- Essential Skills for Chemists (Tutorials) (CHE100)
- Chemistry Research Project (CHE600)
- Chemistry Investigative/ Literature Project (CHE601/2)
- Drug Design and Development (CHE406U)
- Chemistry MSci Research Project (CHE750)
- Pharmaceutical Chemistry MSci Research Project (CHE751)
- Advanced Pharmaceutical Chemistry (CHE306U)
- Advanced Practical Chemistry (CHE301)
Postgraduate Teaching
Teaches on:
- Advanced Pharmaceutical Chemistry (CHE306P)
- Drug Design and Development (CHE406P)
Research
Research Interests:
Research in our group is focused on both protein-protein interactions (PPIs) and protein-DNA interactions and harnessing their potential as drug targets. We do this by using both solution and solid phase synthesis to generate compounds/peptides capable on interacting with these targets. We take inspiration from natural products when designing compounds but also design new molecules from scratch. Within this theme we have several projects:
- Reactivation of the Bcl-2 mediated apoptosis pathway as a way to treat cancer
- Development of new approaches/technology to target PPIs
- Disruption of G-protein coupled receptor (GPCR) heteromers as novel drug targets
- Identification and synthesis of ligands for orphan GPCRs
Research department
Publications
- Browse a list of publications by Lesley Howell
Supervision
Current PhD opportunities
- G-Protein Coupled Receptors as therapeutic targets in drug discovery
- Identification of inhibitors of the pro-survival protein Mcl-1
PhD supervision
Public Engagement
See the Chemistry Department's outreach activities here.