Dr Lesley Howell

Teaching

Lesley is a Queen Mary Academy Fellow for 2021

Undergraduate Teaching

Module Organiser for Pharmaceutical Chemistry (Sem A) (CHE206A), Advanced Pharmaceutical Chemistry (CHE306U) and Professional Skills in Chemistry (CHE310)

Teaches on:

• Essential Skills for Chemists (Tutorials) (CHE100)
• Foundations of Practical Chemistry (CHE101)
• Practical Chemistry (CHE211)
• Essential Skills for Chemists II (CHE210)
• Pharmaceutical Chemistry (Sem A) (CHE206A)
• Advanced Pharmaceutical Chemistry (CHE306)
• Professional Skills in Chemistry (CHE310)
• Chemistry Research Project (CHE600)
• Chemistry Investigative Project (CHE601)
• Chemistry MSci Research Project (CHE700)

Postgraduate Teaching

Teaches on:

• Advanced Pharmaceutical Chemistry (CHE306P)

Research

Research Interests:

Research in our group is focused on two themes:

1. Medicinal Chemistry
2. Chemical Education

The medicinal chemistry research is focused on protein-protein interactions (PPIs) and harnessing their potential as drug targets. We have a particular interest in G-protein Coupled Receptors (GPCRs) and collaborate with the McCormick Group at the WHRi on this. We use both solution and solid phase synthesis to generate compounds/peptides capable on interacting with these targets. We take inspiration from natural products when designing compounds but also design new molecules from scratch. Within this theme we have several projects:

• Development of new approaches/technology to target PPIs
• Disruption of G-protein coupled receptor (GPCR) heteromers as novel drug targets
• Identification and synthesis of ligands for orphan GPCRs

The chemical education research is focused on several areas including outreach and inclusion and diversity. We are interested in the impact of chemistry outreach work. Specifically, what are the most effective forms of outreach and who benefits the most from these with a view to improve the outreach provision here at QMUL and across the UK. We also have an interest in decolonising the National Curriculum (and higher education curriculum) by highlighting the contributions of BAME scientists in the Chemical Sciences and collaborate with Dr Tippu Sheriff on this project. Specific projects include:

• Does chemistry outreach influence a student’s university choices?
• Which chemistry outreach events are the most effective?
• Highlighting the contributions of BAME Scientist within the Chemical Sciences
• The development and implementation of mixed reality environments to enhance the laboratory experience

Research department

• Chemistry

Publications

• Browse a list of publications by Lesley Howell

Supervision

Current PhD opportunities

• G-Protein Coupled Receptors as therapeutic targets in drug discovery
• Identification of inhibitors of the pro-survival protein Mcl-1

PhD supervision

• Zara Farooq
• Christos Matsingos

Public Engagement

See the Chemistry Department's outreach activities here.