School of Biological and Chemical Sciences

Dr Lesley Howell

Lesley

Senior Lecturer

Email: l.howell@qmul.ac.uk
Telephone: +44 (0)20 7882 6625
Room Number: Room G.03, Joseph Priestley building

Undergraduate Teaching

Module Organiser for Advanced Pharmaceutical Chemistry (CHE306U) and Professional Skills for Chemists (CHE401)

Teaches on:

  • Essential Skills for Chemists (Tutorials) (CHE100)
  • Chemistry Research Project (CHE600)
  • Chemistry Investigative/ Literature Project (CHE601/2)
  • Drug Design and Development (CHE406U)
  • Chemistry MSci Research Project (CHE750)
  • Pharmaceutical Chemistry MSci Research Project (CHE751)
  • Advanced Pharmaceutical Chemistry (CHE306U)
  • Advanced Practical Chemistry (CHE301)

 

Postgraduate Teaching

Programme Director for Chemical Research MSc.

Teaches on:

  • Advanced Pharmaceutical Chemistry (CHE306P)
  • Drug Design and Development (CHE406P)

Research

Research Interests:

Research in our group is focused on both protein-protein interactions (PPIs)  and protein-DNA interactions and harnessing their potential as drug targets. We do this by using both solution and solid phase synthesis to generate compounds/peptides capable on interacting with these targets. We take inspiration from natural products when designing compounds but also design new molecules from scratch. Within this theme we have several projects:

  1. Reactivation of the Bcl-2 mediated apoptosis pathway as a way to treat cancer
  2. Development of new approaches/technology to target PPIs
  3. Disruption of G-protein coupled receptor (GPCR) heteromers as novel drug targets
  4. Identification and synthesis of ligands for orphan GPCRs

Research department

Publications

Public Engagement

See the Chemistry Department's outreach activities here.