School of Biological and Chemical Sciences

Dr Lesley Howell


Senior Lecturer and Director of Chemical Research MSc

Telephone: +44 (0)20 7882 6625
Room Number: Room G.03, Joseph Priestley building


Research Interests:

Research in our group is focused on both protein-protein interactions (PPIs)  and protein-DNA interactions and harnessing their potential as drug targets. We do this by using both solution and solid phase synthesis to generate compounds/peptides capable on interacting with these targets. We take inspiration from natural products when designing compounds but also design new molecules from scratch. Within this theme we have several projects:

  1. Reactivation of the Bcl-2 mediated apoptosis pathway as a way to treat cancer
  2. Development of new approaches/technology to target PPIs
  3. Disruption of G-protein coupled receptor (GPCR) heteromers as novel drug targets
  4. Identification and synthesis of ligands for orphan GPCRs

Research department

  • Chemistry

Public Engagement

See the Chemistry Department's outreach activities here.