School of Biological and Chemical Sciences

Jack Bradley-Clarke

PhD student



Project title: Structural molecular biology and synthetic biology of bacterial microcompartments and nanotubes

Summary: Aim to investigate the role of N- terminal extension peptides present in a number of enzymes encapsulated within BMCs, how do they interact with specific shell proteins and enable the encapsulation of non native cargo. PduK features a C- terminal extension which is not homologous to any other known fold, additionaly PduK interacts with Rubisco via its C- terminus through an unknown mechanism, elucidation of this and the structure of the PduK C- terminus would be beneficial.