Haseeb Ur Rehman Shah
Project title: MSTAIT – Modelling, Synthesis and Testing of Anti-Inflammatory and Pro-resolving Therapeutics
Summary: The main scientific objective of the research proposal is to synthesize small organic molecules that will function as new anti-inflammatory therapeutics. Inflammation is key to the body's immune response to injury; however, it also plays a significant role in chronic diseases (e.g. asthma, rhinitis), autoimmune diseases (rheumatoid arthritis), atherosclerosis and strokes, type 1 and type 2 diabetes, certain dementia syndromes (e.g. Alzheimer's disease, Huntington's disease) and some cancers. The classic view of inflammation was that the absence or blocking of these on-messengers, as aspirin does, was enough to enable a passive reduction in swelling. More recently however it has been proven that inflammation can be actively switched off. This project will target this natural inflammation 'off-switch' as it offers an innovative and potentially powerful approach to combating chronic inflammation diseases by enhancing the body's natural responses.