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School of Biological and Chemical Sciences

Towards an innovative and sustainable chemistry

Project description

The Arseniyadis group is principally interested in the development of new synthetic tools to attain high structural and functional complexity. These methods span within the areas of organocatalysis, transition metal catalysis and, more recently, bio-hybrid catalysis. With global environmental legislation becoming stricter, sustainable development has been playing an increasingly important role in the strategy of chemical and pharmaceutical industries allowing asymmetric bio-hybrid catalysis, and more specifically DNA-based asymmetric catalysis, to emerge as a very promising alternative.

The present project aims at developing new DNA-based catalysts with broad applications, rationalizing the chirality transfer induced by the DNA through a careful design of the DNA/catalyst systems, developing sustainable catalysts based on recyclable, solid-supported modified oligonucleotides which will ultimately be implemented to large scale continuous flow processes and ultimately applying these new tools to the synthesis of structurally intriguing natural products that exhibit interesting biological properties.

References

  1. S. Arseniyadis, M. Smietana et al. Chem. Sci. 2019, 10, 2875.
  2. S. Arseniyadis, M. Smietana et al. ChemCatChem 2019 (DOI: 10.1002/cctc.201900743).
  3. L. Evanno, E. Poupon, M. Smietana, S. Arseniyadis et alAngew. Chem. Int. Ed201857, 11786.
  4. S. Arseniyadis, M. Smietana et al. Org. Biomol. Chem. 2017, 15, 7072.
  5. S. Arseniyadis, M. Smietana et alChem. Commun201652, 8604.
  6. S. Arseniyadis, M. Smietana et al. ACS Catal20166, 3096.
  7. S. Arseniyadis, M. Smietana et alChem. Commun201551, 6076.
  8. S. Arseniyadis, M. Smietana et al. Angew. Chem. Int. Ed. 2013, 52, 11546. 

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