School of Biological and Chemical Sciences

Divergent synthesis of polycyclic heterocycles via direct C(sp3)-H bond activation

Supervisor: Dr Christopher R Jones

Project description

The Jones group is interested in developing new synthetic organic chemistry methodology that has the potential to impact upon contemporary socioeconomic issues such as new drug discovery and the need to find more sustainable chemical starting materials. This research project is concerned with the atom-economical synthesis of a range of 3D heterocyclic fragments through direct aliphatic Csp3-H bond activation. This new divergent synthetic method will enable expedient access to a diverse library of complex heterocyclic structures adorned with functionality typically associated with pharmaceutical and agrochemical activity; the properties of these new compounds will then be tested.

Facilities and training

Queen Mary, University of London: One of the UK's leading research-focused higher education institutions, where multidisciplinary research is carried out at the highest level. QMUL is also a member of the prestigious Russell group of top UK universities. It is unique in London by providing a completely integrated residential campus.

Dr Jones’ group is based in a modern building that is fully equipped with state-of-the-art facilities for carrying out outstanding research in organic, inorganic, computational and biological chemistry. Students will receive extensive training in a large number of organic chemistry techniques, and routinely use equipment such as high field NMR, EPR, AFM, IR, UV-Vis and mass spectrometers, in addition to LCMS, GCMS and HPLC. Single crystal X-ray diffractometry is also available. We hold joint research group meetings on a weekly basis that cover theoretical organic chemistry problems, research update presentations and discussions of highlights from the recent literature. All researchers are part of the QMUL Doctoral College, which provides high quality training in transferable key skills such as communication, critical thinking, teamwork and entrepreneurship. Free English language courses are also available through the Queen Mary Language Centre.

Eligibility and applying

see entry requirementsInternational students must provide evidence of proficient English language skills. A strong background in organic synthesis and practical research experience are essential.

Potential candidates should contact Dr Jones by email and submit their CV (including details of two referees) and a cover letter explaining their eligibility and interest in this project. Shortlisted candidates will be contacted by email to arrange for a video interview.

See also