School of Biological and Chemical Sciences

Metal-free C(sp3)-H arylation of unsaturated heterocycles

Supervisor: Dr Christopher R Jones

Project description

The Jones group is interested in developing new synthetic organic chemistry methodology that has the potential to impact upon contemporary socioeconomic issues such as new drug discovery and the need to find more sustainable chemical starting materials. This research project aims to develop a novel synthetic method for the metal-free C-H arylation of unsaturated heterocycles, as direct activation of C-H bonds significantly reduces cost, time and waste in comparison to traditional preactivation tactics. Late-stage functionalisation of heterocycles will produce new architectures for biological testing, as well as provide more efficient routes to known structures.

Facilities and training

One of the UK's leading research-focused higher education institutions, where multidisciplinary research is carried out at the highest level. QMUL is also a member of the prestigious Russell group of top UK universities. It is unique in London by providing a completely integrated residential campus.

Dr Jones’ group is based in a modern building that is fully equipped with state-of-the-art facilities for carrying out outstanding research in organic, inorganic, computational and biological chemistry. Students will receive extensive training in a large number of organic chemistry techniques, and routinely use equipment such as high field NMR, EPR, AFM, IR, UV-Vis and mass spectrometers, in addition to LCMS, GCMS and HPLC. Single crystal X-ray diffractometry is also available. We hold joint research group meetings on a weekly basis that cover theoretical organic chemistry problems, research update presentations and discussions of highlights from the recent literature. All researchers are part of the QMUL Doctoral College, which provides high quality training in transferable key skills such as communication, critical thinking, teamwork and entrepreneurship. Free English language courses are also available through the Queen Mary Language Centre.

Eligibility and applying

See SBCS entry requirementsInternational students must provide evidence of proficient English language skill. A strong background in organic synthesis and practical research experience are essential.

Potential candidates should contact Dr Jones by email and submit their CV (including details of two referees) and a cover letter explaining their eligibility and interest in this project. Shortlisted candidates will be contacted by email to arrange for a video interview.

See also