Classification of Membrane Transport Proteins

List of Families and Subfamilies of the TC System

Family 1

1. Pores and channels
1.A a-Helical channels
1.A.1	Voltage-gated ion channel superfamily	VIC
1.A.2	Animal inward-rectifier K⁺ channel	IRK-C
1.A.3	Ryanodine-inositol-1,4,5-trisphosphate receptor Ca²⁺ channel	RIR-CaC
1.A.4	Transient receptor potential Ca²⁺ channel	TRP-CC
1.A.5	Polycystin cation channel	PCC
1.A.6	Epithelial Na⁺ channel	ENaC
1.A.7	ATP-gated cation channel	ACC
1.A.8	Major intrinsic protein	MIP
1.A.9	Ligand-gated ion channel of neurotransmitter receptors	LIC
1.A.10	Glutamate-gated ion channel of neurotransmitter receptors	GIC
1.A.11	Chloride channel	ClC
1.A.12	Organellar chloride channel	O-ClC
1.A.13	Epithelial chloride channel	E-ClC
1.A.14	Nonselective cation channel-1	NSCC1
1.A.15	Nonselective cation channel-2	NSCC2
1.A.16	Yeast stretch-activated, cation-selective, Ca²⁺ channel	Mid1
1.A.17	Chloroplast outer-membrane solute channel	CSC
1.A.18	Chloroplast membrane anion-channel-former	Tic110
1.A.19	Influenza virus matrix-2 channel	M2-C
1.A.20	gp91^phox phagocyte NADPH-oxidase-associated cyt b₅₅₈ H⁺-channel	CytB
1.A.21	Apoptosis regulator	Bcl-2
1.A.22	Large-conductance mechanosensitive ion channel	MscL
1.A.23	Small-conductance mechanosensitive ion channel	MscS
1.A.24	Gap-junction-forming connexin	Connexin
1.A.25	Gap-junction-forming innexin	Innexin
1.A.26	Plant plasmodesmata	PPD
1.A.27	Phospholemman	PLM
1.A.28	Urea transporter (channel)	UT
1.A.29	Urea/amide channel	UAC
1.A.30	H⁺- or Na⁺-translocating bacterial MotAB flagellar motor/ExbBD outer-membrane transport energizer superfamily	Mot /Exb
1.A.30.1	H⁺- or Na⁺-translocating bacterial flagellar motor	Mot
1.A.30.2	TonB-ExbB-ExbD/TolA-TolQ-TolR of energizers for outer-membrane receptor (OMR)-mediated active transport	Exb
1.A.31	Annexin	Annexin
1.A.32	Type B influenza virus NB channel	NB-C
1.A.33	Cation-channel-forming heat-shock protein 70	Hsp70
1.A.34	Envelope virus E1 channel	EVE1-C
1.A.35	Metal-ion transporter (channel)	MIT
1.A.36	Intracellular chloride channel	ICC

1.B b-Strand porins

1.B.1 General bacterial porin GBP

1.B.2 Chlamydial porin CP

1.B.3 Sugar porin SP

1.B.4 Brucella-Rhizobium porin BRP

1.B.5 Pseudomonas OprP porin POP

1.B.6 OmpA-OmpF porin OOP

1.B.7 Rhodobacter PorCa porin RPP

1.B.8 Mitochondrial and plastid porin MPP

1.B.9 FadL outer-membrane protein FadL

1.B.10 Nucleoside-specific channel-forming outer-membrane porin Tsx

1.B.11 Outer-membrane fimbrial usher porin FUP

1.B.12 Autotransporter AT

1.B.13 Alginate export porin AEP

1.B.14 Outer-membrane receptor OMR

1.B.15 Raffinose porin RafY

1.B.16 Short-chain amide and urea porin SAP

1.B.17 Outer-membrane factor OMF

1.B.18 Outer-membrane auxiliary protein OMA

1.B.19 Glucose-selective OprB porin OprB

1.B.20 Two-partner secretion porin TPS

1.B.21 OmpG porin OmpG

1.B.22 Outer-bacterial-membrane secretin Secretin

1.B.23 Cyanobacterial porin CBP

1.B.24 Mycobacterial porin MBP

1.B.25 Outer-membrane porin OPr

1.B.26 Cyclodextrin porin CDP

1.B.27 Helicobacter outer membrane porin Hop

1.B.28 Plastid outer-envelope porin of 24 kDa OEP24

1.B.29 Plastid outer-envelope porin of 21 kDa OEP21

1.B.30 Plastid outer-envelope porin of 16 kDa OEP16

1.B.31 Campylobacter jejuni major outer membrane porin MomP

1.B.32 Fusobacterial outer-membrane porin FomP

1.B.33 Vibrio chitoporin/Neisseria porin VC/NP

1.B.34 Corynebacterial porin PorA

1.C Pore-forming toxins

1.C.1 Channel-forming colicin Colicin

1.C.2 Channel-forming d-endotoxin insecticidal crystal protein ICP

1.C.3 a-Hemolysin channel-forming toxin aHL

1.C.4 Aerolysin channel-forming toxin Aerolysin

1.C.5 Channel-forming e-toxin e-Toxin

1.C.6 Yeast killer toxin K1 YKT-K1

1.C.7 Diphtheria toxin DT

1.C.8 Botulinum and tetanus toxin BTT

1.C.9 Vacuolating cytotoxin VacA

1.C.10 Pore-forming hemolysin E HlyE

1.C.11 Pore-forming RTX toxin RTX-toxin

1.C.12 Cholesterol-binding, thiol-activated cytolysin TAC

1.C.13 Channel-forming leukocidin cytotoxin Ctx

1.C.14 Cytohemolysin CHL

1.C.15 Whipworm stichosome porin WSP

1.C.16 Magainin Magainin

1.C.17 Cecropin Cecropin

1.C.18 Melittin Melittin

1.C.19 Defensin Defensin

1.C.20 Nisin Nisin

1.C.21 Lacticin 481 Lacticin 481

1.C.22 Lactococcin A Lactococcin A

1.C.23 Lactocin S Lactocin S

1.C.24 Pediocin Pediocin

1.C.25 Lactococcin G Lactococcin G

1.C.26 Lactacin X Lactacin X

1.C.27 Divergicin A Divergicin A

1.C.28 AS-48 AS-48

1.C.29 Plantaricin EF Plantaricin EF

1.C.30 Plantaricin JK Plantaricin JK

1.C.31 Channel-forming colicin V Colicin V

1.C.32 Amphipathic peptide mastoparan Mastoparan

1.C.33 Cathilicidin Cathilicidin

1.C.34 Tachyplesin Tachyplesin

1.C.35 Amoebapore Amoebapore

1.C.36 Bacterial type III-target cell pore IIITCP

1.C.37 Lactococcin 972 Lactococcin 972

1.C.38 Pore-forming equinatoxin Equinatoxin

1.C.39 Complement protein C9 CPC9

1.C.40 Bactericidal permeability-increasing protein BPIP

1.C.41 Tripartite hemolysin BL HBL

1.C.42 Channel-forming Bacillus anthrax protective antigen BAPA

1.C.43 Earthworm lysenin toxin Lysenin

1.C.44 Plant thionine PT

1.C.45 Plant defensin PD

1.C.46 C-type natriuretic peptide CNP

1.C.47 Insect defensin Insect defensin

1.C.48 Prion peptide fragment PPF

1.C.49 Cytotoxic amylin Amylin

1.C.50 Amyloid b-protein peptide AbPP

1.C.51 Pilosulin Pilosulin

1.C.52 Dermaseptin Dermaseptin

1.C.53 Bacteriocin AS-48 cyclic polypeptide Bacteriocin AS-48

1.C.54 Shiga toxin B-chain ST-B

1.C.55 Agrobacterial target-host cell-membrane anion channel VirE2

1.C.56 Pseudomanas syringae HrpZ target-host cell-membrane HrpZ

cation channel

1.C.57 Clostridial cytotoxin CCT

1.C.58 Microcin E492 Microcin E492

1.D Non-ribosomally synthesized channels

1.D.1 Gramicidin A channel Gramicidin A

1.D.2 Syringomycin channel Syringomycin

1.D.3 Syringopeptin channel Syringopeptin

1.D.4 Tolaasin channel Tolaasin

1.D.5 Alamethicin channel Alamethicin

1.D.6 Complexed polyhydroxybutyrate-Ca²⁺ channel cPHB-CC

1.D.7 Beticolin channel Beticolin

1.D.8 Saponin channel Saponin

1.D.9 Polyglutamine ion channel PG-IC

1.D.10 Channel-forming ceramide Ceramide

1.E Holins

1.E.1 P21 holin S P21 Holin

1.E.2 lholin S lHolin

1.E.3 P2 holin TM P2 Holin

1.E.4 LydA holin LydA Holin

1.E.5 PRD1 holin M PRD1 Holin

1.E.6 T7 holin T7 Holin

1.E.7 HP1 holin HP1 Holin

1.E.8 T4 holin T4 Holin

1.E.9 T4 Immunity holin T4 Immunity Holin

1.E.10 Bacillus subtilis j29 holin j29 Holin

1.E.11 j11 holin j11 Holin

1.E.12 jAdh holin jAdh Holin

1.E.13 jU53 holin j53 Holin

1.E.14 LrgA holin LrgA Holin

1.E.15 ArpQ holin ArpQ Holin

1.E.16 Cph1 holin Cph1 Holin

1.E.17 BlyA holin BlyA Holin

1.E.18 Lactococcus lactis phage r1t holin r1t Holin

1.E.19 Clostridium difficile TcdE holin TcdE Holin

Continued with List of Family 2
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1.B b-Strand porins
1.B.1	General bacterial porin	GBP
1.B.2	Chlamydial porin	CP
1.B.3	Sugar porin	SP
1.B.4	Brucella-Rhizobium porin	BRP
1.B.5	Pseudomonas OprP porin	POP
1.B.6	OmpA-OmpF porin	OOP
1.B.7	Rhodobacter PorCa porin	RPP
1.B.8	Mitochondrial and plastid porin	MPP
1.B.9	FadL outer-membrane protein	FadL
1.B.10	Nucleoside-specific channel-forming outer-membrane porin	Tsx
1.B.11	Outer-membrane fimbrial usher porin	FUP
1.B.12	Autotransporter	AT
1.B.13	Alginate export porin	AEP
1.B.14	Outer-membrane receptor	OMR
1.B.15	Raffinose porin	RafY
1.B.16	Short-chain amide and urea porin	SAP
1.B.17	Outer-membrane factor	OMF
1.B.18	Outer-membrane auxiliary protein	OMA
1.B.19	Glucose-selective OprB porin	OprB
1.B.20	Two-partner secretion porin	TPS
1.B.21	OmpG porin	OmpG
1.B.22	Outer-bacterial-membrane secretin	Secretin
1.B.23	Cyanobacterial porin	CBP
1.B.24	Mycobacterial porin	MBP
1.B.25	Outer-membrane porin	OPr
1.B.26	Cyclodextrin porin	CDP
1.B.27	Helicobacter outer membrane porin	Hop
1.B.28	Plastid outer-envelope porin of 24 kDa	OEP24
1.B.29	Plastid outer-envelope porin of 21 kDa	OEP21
1.B.30	Plastid outer-envelope porin of 16 kDa	OEP16
1.B.31	Campylobacter jejuni major outer membrane porin	MomP
1.B.32	Fusobacterial outer-membrane porin	FomP
1.B.33	Vibrio chitoporin/Neisseria porin	VC/NP
1.B.34	Corynebacterial porin	PorA

1.C Pore-forming toxins
1.C.1	Channel-forming colicin	Colicin
1.C.2	Channel-forming d-endotoxin insecticidal crystal protein	ICP
1.C.3	a-Hemolysin channel-forming toxin	aHL
1.C.4	Aerolysin channel-forming toxin	Aerolysin
1.C.5	Channel-forming e-toxin	e-Toxin
1.C.6	Yeast killer toxin K1	YKT-K1
1.C.7	Diphtheria toxin	DT
1.C.8	Botulinum and tetanus toxin	BTT
1.C.9	Vacuolating cytotoxin	VacA
1.C.10	Pore-forming hemolysin E	HlyE
1.C.11	Pore-forming RTX toxin	RTX-toxin
1.C.12	Cholesterol-binding, thiol-activated cytolysin	TAC
1.C.13	Channel-forming leukocidin cytotoxin	Ctx
1.C.14	Cytohemolysin	CHL
1.C.15	Whipworm stichosome porin	WSP
1.C.16	Magainin	Magainin
1.C.17	Cecropin	Cecropin
1.C.18	Melittin	Melittin
1.C.19	Defensin	Defensin
1.C.20	Nisin	Nisin
1.C.21	Lacticin 481	Lacticin 481
1.C.22	Lactococcin A	Lactococcin A
1.C.23	Lactocin S	Lactocin S
1.C.24	Pediocin	Pediocin
1.C.25	Lactococcin G	Lactococcin G
1.C.26	Lactacin X	Lactacin X
1.C.27	Divergicin A	Divergicin A
1.C.28	AS-48	AS-48
1.C.29	Plantaricin EF	Plantaricin EF
1.C.30	Plantaricin JK	Plantaricin JK
1.C.31	Channel-forming colicin V	Colicin V
1.C.32	Amphipathic peptide mastoparan	Mastoparan
1.C.33	Cathilicidin	Cathilicidin
1.C.34	Tachyplesin	Tachyplesin
1.C.35	Amoebapore	Amoebapore
1.C.36	Bacterial type III-target cell pore	IIITCP
1.C.37	Lactococcin 972	Lactococcin 972
1.C.38	Pore-forming equinatoxin	Equinatoxin
1.C.39	Complement protein C9	CPC9
1.C.40	Bactericidal permeability-increasing protein	BPIP
1.C.41	Tripartite hemolysin BL	HBL
1.C.42	Channel-forming Bacillus anthrax protective antigen	BAPA
1.C.43	Earthworm lysenin toxin	Lysenin
1.C.44	Plant thionine	PT
1.C.45	Plant defensin	PD
1.C.46	C-type natriuretic peptide	CNP
1.C.47	Insect defensin	Insect defensin
1.C.48	Prion peptide fragment	PPF
1.C.49	Cytotoxic amylin	Amylin
1.C.50	Amyloid b-protein peptide	AbPP
1.C.51	Pilosulin	Pilosulin
1.C.52	Dermaseptin	Dermaseptin
1.C.53	Bacteriocin AS-48 cyclic polypeptide	Bacteriocin AS-48
1.C.54	Shiga toxin B-chain	ST-B
1.C.55	Agrobacterial target-host cell-membrane anion channel	VirE2
1.C.56	Pseudomanas syringae HrpZ target-host cell-membrane	HrpZ
	cation channel
1.C.57	Clostridial cytotoxin	CCT
1.C.58	Microcin E492	Microcin E492

1.D Non-ribosomally synthesized channels
1.D.1	Gramicidin A channel	Gramicidin A
1.D.2	Syringomycin channel	Syringomycin
1.D.3	Syringopeptin channel	Syringopeptin
1.D.4	Tolaasin channel	Tolaasin
1.D.5	Alamethicin channel	Alamethicin
1.D.6	Complexed polyhydroxybutyrate-Ca²⁺ channel	cPHB-CC
1.D.7	Beticolin channel	Beticolin
1.D.8	Saponin channel	Saponin
1.D.9	Polyglutamine ion channel	PG-IC
1.D.10	Channel-forming ceramide	Ceramide

1.E Holins
1.E.1	P21 holin S	P21 Holin
1.E.2	lholin S	lHolin
1.E.3	P2 holin TM	P2 Holin
1.E.4	LydA holin	LydA Holin
1.E.5	PRD1 holin M	PRD1 Holin
1.E.6	T7 holin	T7 Holin
1.E.7	HP1 holin	HP1 Holin
1.E.8	T4 holin	T4 Holin
1.E.9	T4 Immunity holin	T4 Immunity Holin
1.E.10	Bacillus subtilis j29 holin	j29 Holin
1.E.11	j11 holin	j11 Holin
1.E.12	jAdh holin	jAdh Holin
1.E.13	jU53 holin	j53 Holin
1.E.14	LrgA holin	LrgA Holin
1.E.15	ArpQ holin	ArpQ Holin
1.E.16	Cph1 holin	Cph1 Holin
1.E.17	BlyA holin	BlyA Holin
1.E.18	Lactococcus lactis phage r1t holin	r1t Holin
1.E.19	Clostridium difficile TcdE holin	TcdE Holin