Classification of Membrane Transport Proteins

Continued from class 1

Classification of Transport Proteins According to Substrate Specificity

2. Outer Membrane Porins (most from Gram-negative bacteria)

Contents

I.A. Nonselective
I.C. Cations
I.D. Anions
II.A. Sugars and polyols
II.B. Monocarboxylates
II.E. Others
III.A. Amides
IV.B. Nucleosides
IV.C. Nucleotides
V.A. Vitamins
V.B. Enzyme and redox cofactors
V.C. Iron-siderophores
VI.A. Multiple drugs
VII.A. Carbohydrates
VII.B. Proteins

I.A. Nonselective

SubstrateTC numberFamily
Nonselective 1.B.1, -2, -4, -6, -7,
  -8, -21, -23-26
GBP, CP, BRP, OOP, RPP, MPP,
   OmpG, CBP, MBP, Opr, CDP
Nonselective (slight
cation selectivity)
1.B.15.1.1RafY

I.C. Cations

Fe3+- or Fe3+-chelate-selective1.B.14.3.2OMR
Metal ions1.B.17.2.1OMF

I.D. Anions

Anion-selective1.B.1.6.1GBP
1.B.8MPP
1.B.13AEP
Phosphate-selective1.B.1.1.2GBP
1.B.5.1.1POP
Diphosphate-selective1.B.5.1.2POP

II.A. Sugars and polyols

Glucose 1.B.19.1.1OprB
Maltooligosaccharide-selective1.B.3.1.1SP
Oligosaccharide-selective1.B.3.1.2SP

II.B. Monocarboxylates

Fatty-acid-selective1.B.9.1.1FadL

II.E. Others

Toluene-selective1.B.9.2.1FadL

III.A. Amides

Amides, short chain1.B.16.1.1SAP
Urea 1.B.16.1.1SAP

IV.B. Nucleosides

Nucleoside-selective1.B.10.1.1Tsx

IV.C. Nucleotides

Nucleotide-selective1.B.1.1.4GBP

V.A. Vitamins

Cobalamin-selective1.B.14.3.1OMR

V.B. Enzyme and redox cofactors

Heme 1.B.14.2.3OMR
Porphyrin 1.B.14.3.1OMR

V.C. Iron-siderophores

Iron-complex-selective1.B.14.1.1-4;
  1.B.14.2-3
OMR
Fe3+-catecholate1.B.14.3.2OMR
Fe3+-citrate1.B.14.1.2OMR
Fe3+-coprogen1.B.14.1.3OMR
Fe3+-enterobactin1.B.14.1.1OMR
Ferrichrome 1.B.14.1.4OMR
Heme 1.B.14.2.3OMR
1.B.20.3.1TEC

VI.A. Multiple drugs

Drug (multiple)-selective1.B.17.1.1OMF
1.B.17.3.2OMF
1.B.17.3.3OMF

VII.A. Carbohydrates

Alginate (acidic polysaccharide)1.B.13.1.1AEP
Capsular- or
exopolysaccharide-selective
1.B.18.1.1-2;
  1.B.18.2.1
OMA
Lipooligosaccharide-selective1.B.17.3.1OMF
Polymannonate 1.B.13.1.1AEP
Polysaccharide-selective1.B.13.1.1AEP

VII.B. Proteins

Albomycin 1.B.14.1.4OMR
Colicin I-selective1.B.14.3.2OMR
Colicin M-selective1.B.14.1.4OMR
Colicin B-selective1.B.14.1.1OMR
Colicin D-selective1.B.14.1.1OMR
Fimbrial-subunit-selective1.B.11.1-3FUP
Hemin-selective1.B.14.2.3OMR
Hemoglobin-selective1.B.14.2.2OMR
Protein (virulence factor)-selective1.B.12AT
Protein (hemolysin)-selective1.B.17.1.1OMF
1.B.20.1.2TEC
Protein (hemagglutinin)-selective1.B.20.2.1TEC
Protein (protease)-selective1.B.17.1.2OMF
Protein (cyclolysin)-selective1.B.17.2.3OMF
Protein (toxin)-selective1.B.20.1.1TEC
Transferrin-selective1.B.14.2.1OMR
Protein (competence factor)-selective1.B.22.1.6Secretin
Protein (secretory protein)-selective1.B.22.1.1Secretin
Protein (fimbrial subunit)-selective1.B.22.1.3Secretin
Protein (virulence factor)-selective1.B.22.1.2;
  1.B.22.1.4;
  1.B.22.1.5
Secretin
Protein (phage)-selective1.B.22.1.7Secretin


Continued with Class 3
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