AMP Catabolism

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© IUBMB 2003

This pathway of breakdown of purines goes as far as urate in primates and some other animals, and on to allantoate in many others. Legumes can transport nitrogen as allantoin and allantoate, and release ammonia by the reactions shown at the bottom of the scheme. Some of these are restricted to certain bacteria.


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AMP biosynthesis
EC 1.1.1.154 ureidoglycolate dehydrogenase [NAD(P)+]
EC 1.1.1.350 ureidoglycolate dehydrogenase (NAD+)
EC 1.7.3.3 urate oxidase
EC 1.14.11.48 xanthine dioxygenase
EC 1.17.1.4 xanthine dehydrogenase
EC 1.17.3.2 xanthine oxidase
EC 2.1.3.5 oxamate carbamoyltransferase
EC 2.7.2.2 carbamate kinase
EC 3.2.2.12 inosinate nucleosidase
EC 3.5.2.5 allantoinase
EC 3.5.2.17 hydroxyisourate hydrolase
EC 3.5.3.4 allantoicase
EC 3.5.3.9 allantoate deiminase
EC 3.5.3.19 ureidoglycolate hydrolase
EC 3.5.3.26 (S)-ureidoglycine aminohydrolase
EC 3.5.4.6 AMP deaminase
EC 4.1.1.97 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline decarboxylase
EC 4.3.2.3 ureidoglycolate lyase
EC 5.1.99.3 allantoin racemase