IUBMB Enzyme Nomenclature

EC 7.6.2.4

Accepted name: ABC-type fatty-acyl-CoA transporter

Reaction: ATP + H2O + fatty acyl CoA[side 1] = ADP + phosphate + fatty acyl CoA[side 2]

Other name(s): fatty-acyl-CoA-transporting ATPase

Systematic name: ATP phosphohydrolase (ABC-type, fatty-acyl-CoA-transporting)

Comments: An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. An animal and yeast enzyme that transports fatty acyl CoA into and out of peroxisomes. In humans, it is associated with Zellweger's syndrome.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Kamijo, K., Taketani, S., Yokota, S., Osumi, T. and Hashimoto, T. The 70-kDa peroxisomal membrane protein is a member of the Mdr (P-glcoprotein)-related ATP-binding protein superfamily. J. Biol. Chem. 265 (1990) 4534-4540. [PMID: 1968461]

2. Hettema, E.H., van Roermund, C.W.T., Distel, B. , van den Berg. M., Vilela, C., Rodrigues-Posada, C., Wanders, R.J.A. and Tabak, H.F. The ABC transporter proteins Pat1 and Pat2 are required for import of long-chain fatty acids into peroxisomes of Saccharomyces cerevisiae. EMBO J. 15 (1996) 3813-3822. [PMID: 8670886]

3. Saier, M.H., Jr. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv. Microb. Physiol. 40 (1998) 81-136. [PMID: 9889977]

[EC 7.6.2.4 created 2000 as EC 3.6.3.47, transferred 2018 to EC 7.6.2.4]


Return to EC 7.6.2 home page
Return to EC 7.6 home page
Return to EC 7 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page