IUBMB Enzyme Nomenclature


Accepted name: ABC-type dipeptide transporter

Reaction: ATP + H2O + a dipeptide-[dipeptide-binding protein][side 1] = ADP + phosphate + a dipeptide[side 2] + [dipeptide-binding protein][side 1]

Other name(s): dipeptide transporting ATPase; dipeptide ABC transporter; dppBCDF (gene names)

Systematic name: ATP phosphohydrolase (ABC-type, dipeptide-transporting)

Comments: ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. A bacterial enzyme that interacts with an extracytoplasmic substrate binding protein and mediates the uptake of di- and tripeptides. The enzyme from Pseudomonas aeruginosa can interact with five different substrate binding proteins.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Abouhamad, W.N., Manson, M., Gibson, M.M. and Higgins, C.F. Peptide transport and chemotaxis in Escherichia coli and Salmonella typhimurium: characterization of the dipeptide permease (Dpp) and the dipeptide-binding protein. Mol. Microbiol. 5 (1991) 1035-1047. [PMID: 1956284]

2. Sanz, Y., Lanfermeijer, F.C., Renault, P., Bolotin, A., Konings, W.N. and Poolman, B. Genetic and functional characterization of dpp genes encoding a dipeptide transport system in Lactococcus lactis. Arch. Microbiol. 175 (2001) 334-343. [PMID: 11409543]

3. Li, X., Zhuo, W., Yu, J., Ge, J., Gu, J., Feng, Y., Yang, M., Wang, L. and Wang, N. Structure of the nucleotide-binding domain of a dipeptide ABC transporter reveals a novel iron-sulfur cluster-binding domain. Acta Crystallogr. D Biol. Crystallogr. 69 (2013) 256-265. [PMID: 23385461]

4. Pletzer, D., Lafon, C., Braun, Y., Kohler, T., Page, M.G., Mourez, M. and Weingart, H. High-throughput screening of dipeptide utilization mediated by the ABC transporter DppBCDF and its substrate-binding proteins DppA1-A5 in Pseudomonas aeruginosa. PLoS One 9 (2014) e111311. [PMID: 25338022]

[EC created 2018]

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