IUBMB Enzyme Nomenclature

EC 7.4.2.5

Accepted name: ABC-type protein transporter

Reaction: ATP + H2O + protein[side 1] = ADP + phosphate + protein[side 2]

Other name(s): peptide-transporting ATPase (ambiguous)

Systematic name: ATP phosphohydrolase (ABC-type, peptide-exporting)

Comments: An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. This entry stands for a family of bacterial enzymes. Members of this family from Gram-negative bacteria were reported to export α-hemolysin, cyclolysin, colicin V and siderophores, while members from Gram-positive bacteria are known to export bacteriocin, subtilin, competence factor and pediocin.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Klein, C. and Entian, K.D. Genes involved in self-protection against the lantibiotic subtilin produced by Bacillus subtilis ATCC 6633. Appl. Environ. Microbiol. 60 (1994) 2793-2801. [PMID: 8085823]

2. Momburg, F., Roelse, J., Howard, J.C., Butcher, G.W., Hammerling, G.J. and Neefjes, J.J. Selectivity of MHC-encoded peptide transporters from human, mouse and rat. Nature 367 (1994) 648-651. [PMID: 8107849]

3. Binet, R., Létoffé, S., Ghigo, J.M., Delepaire, P. and Wanderman, C. Protein secretion by Gram-negative bacterial ABC exporters - a review. Gene 192 (1997) 7-11. [PMID: 9224868]

[EC 7.4.2.5 created 2000 as EC 3.6.3.43, transferred 2018 to EC 7.4.2.5]


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