IUBMB Enzyme Nomenclature

EC 7.2.2.2

Accepted name: ABC-type Cd2+ transporter

Reaction: ATP + H2O + Cd2+[side 1] = ADP + phosphate + Cd2+[side 2]

Other name(s): cadmium-transporting ATPase (ambiguous); ABC-type cadmium-transporter

Systematic name: ATP phosphohydrolase (ABC-type, heavy-metal-exporting)

Comments: An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins. Does not undergo phosphorylation during the transport process. A yeast enzyme that exports some heavy metals, especially Cd2+, from the cytosol into the vacuole.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:

References:

1. Li, Z.S., Szczypka, M., Lu, Y.P., Thiele, D.J. and Rea, P.A. The yeast cadmium factor protein (YCF1) is a vacuolar glutathione S-conjugate pump. J. Biol. Chem. 271 (1996) 6509-6517. [PMID: 8626454]

2. Saier, M.H., Jr. Molecular phylogeny as a basis for the classification of transport proteins from bacteria, archaea and eukarya. Adv. Microb. Physiol. 40 (1998) 81-136. [PMID: 9889977]

[EC 7.2.2.2 created 2000 as EC 3.6.3.46, transferred 2018 to EC 7.2.2.2]


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