IUBMB Enzyme Nomenclature


Accepted name: H+-exporting ATPase

Reaction: ATP + H2O + H+[side 1] = ADP + phosphate + H+[side 2]

Other name(s): proton-translocating ATPase; yeast plasma membrane H+-ATPase; yeast plasma membrane ATPase; ATP phosphohydrolase (ambiguous)

Systematic name: ATP phosphohydrolase (H+-exporting)

Comments: A P-type ATPase that undergoes covalent phosphorylation during the transport cycle. This enzyme occurs in protozoa, fungi and plants, and generates an electrochemical potential gradient of protons across the plasma membrane.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number:


1. Goffeau, A. and Slayman, C. The proton-translocating ATPase of the fungal plasma membrane. Biochim. Biophys. Acta 639 (1981) 197-223. [PMID: 6461354]

2. Serrano, R., Kielland-Brandt, M.C. and Fink, G.R. Yeast plasma membrane ATPase is essential for growth and has homology with (Na++K+)-, K+-and Ca2+-ATPases. Nature 319 (1986) 689-693. [PMID: 3005867]

3. Serrano, R. and Portillo, F. Catalytic and regulatory sites of yeast plasma membrane H+-ATPase studied by directed mutagenesis. Biochim. Biophys. Acta 1018 (1990) 195-199. [PMID: 2144186]

4. Perlin, D.S., San Francisco, M.J., Slayman, C.W. and Rosen, B.P. H+/ATP stoichiometry of proton pumps from Neurospora crassa and Escherichia coli. Arch. Biochem. Biophys. 248 (1986) 53-61. [PMID: 2425739]

[EC created 1984 as EC, transferred 2000 to EC, transferred 2018 to EC]

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