IUBMB Enzyme Nomenclature

EC 6.4.1.6

Accepted name: acetone carboxylase

Reaction: acetone + CO2 + ATP + 2 H2O = acetoacetate + AMP + 2 phosphate

Systematic name: acetone:carbon-dioxide ligase (AMP-forming)

Comments: Requires Mg2+ and ATP. The enzyme from Xanthobacter sp. strain Py2 also carboxylates butan-2-one to 3-oxopentanoate.

Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 189258-15-9

References:

1. Sluis, M.K. and Ensign, S.A. Purification and characterization of acetone carboxylase from Xanthobacter strain Py2. Proc. Natl. Acad. Sci. USA 94 (1997) 8456-8461. [PMID: 9237998]

[EC 6.4.1.6 created 2001]


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