IUBMB Enzyme Nomenclature


Accepted name: pyruvate carboxylase

Reaction: ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate

Other name(s): pyruvic carboxylase

Systematic name: pyruvate:carbon-dioxide ligase (ADP-forming)

Comments: A biotinyl-protein containing manganese (animal tissues) or zinc (yeast). The animal enzyme requires acetyl-CoA.

Links to other databases: BRENDA, EXPASY, GTD, KEGG, Metacyc, PDB, CAS registry number: 9014-19-1


1. McClure, W.R., Lardy, H.A. and Kneifel, H.P. Rat liver pyruvate carboxylase. I. Preparation, properties, and cation specificity. J. Biol. Chem. 246 (1971) 3569-3578. [PMID: 5578910]

2. Scrutton, M.C., Young, M.R. and Utter, M.F. Pyruvate carboxylase from baker's yeast. The presence of bound zinc. J. Biol. Chem. 245 (1970) 6220-6227. [PMID: 5484476]

3. Seubert, W. and Remberger, U. Renigung und Wirkungsweise der Pyruvatcarboxylase aus Pseudomonas citronellolis. Biochem. Z. 334 (1961) 401-414.

4. Utter, M.F. and Keech, D.B. Pyruvate carboxylase. I. Nature of the reaction. J. Biol. Chem. 238 (1963) 2603-2608.

[EC created 1961]

Return to EC 6.4.1 home page
Return to EC 6.4 home page
Return to EC 6 home page
Return to Enzymes home page
Return to IUBMB Biochemical Nomenclature home page