Reaction: ATP + ribose 5-phosphate + NH3 = ADP + phosphate + 5-phosphoribosylamine
For diagram of reaction click here.
Other name(s): 5-phosphoribosylamine synthetase; ribose 5-phosphate aminotransferase; ammonia-ribose 5-phosphate aminotransferase
Systematic name: ribose-5-phosphate:ammonia ligase (ADP-forming)
Links to other databases: BRENDA, EXPASY, KEGG, Metacyc, CAS registry number: 9082-52-4
References:
1. Reem, G.H. Enzymatic synthesis of 5'-phosphoribosylamine from ribose 5-phosphate and ammonia, an alternate first step in purine biosynthesis. J. Biol. Chem. 243 (1968) 5695-5701. [PMID: 5699059]