IUBMB Enzyme Nomenclature

EC 6.3.2.48

Accepted name: L-arginine-specific L-amino acid ligase

Reaction: ATP + L-arginine + an L-amino acid = ADP + phosphate + an L-arginyl-L-amino acid

Other name(s): RizA; L-amino acid ligase RizA

Systematic name: L-arginine:L-amino acid ligase (ADP-forming)

Comments: The enzyme, characterized from the bacterium Bacillus subtilis, requires Mn2+ for activity. It shows strict substrate specificity toward L-arginine as the first (N-terminal) amino acid of the product. The second amino acid could be any standard protein-building amino acid except for L-proline.

Links to other databases: BRENDA, EXPASY, KEGG, MetaCyc, CAS registry number:

References:

1. Kino, K., Kotanaka, Y., Arai, T. and Yagasaki, M. A novel L-amino acid ligase from Bacillus subtilis NBRC3134, a microorganism producing peptide-antibiotic rhizocticin. Biosci. Biotechnol. Biochem. 73 (2009) 901-907. [PMID: 19352016]

[EC 6.3.2.48 created 2015]


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